Role of the Extracellular Traps in Central Nervous System

It has been reported that several immune cells can release chromatin and granular proteins into extracellular space in response to the stimulation, forming extracellular traps (ETs). The cells involved in the extracellular trap formation are recognized including neutropils, macrophages, basophils, e...

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Autores principales:	Xinyan Wu, Hanhai Zeng, Lingxin Cai, Gao Chen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	extracellular traps neuroinflammation blood–brain barrier (BBB) stroke neurodegenaration CNS Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/c890f94a0d6a4c68951ac1d4ffbed621
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id	oai:doaj.org-article:c890f94a0d6a4c68951ac1d4ffbed621
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spelling	oai:doaj.org-article:c890f94a0d6a4c68951ac1d4ffbed6212021-11-16T06:11:30ZRole of the Extracellular Traps in Central Nervous System1664-322410.3389/fimmu.2021.783882https://doaj.org/article/c890f94a0d6a4c68951ac1d4ffbed6212021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.783882/fullhttps://doaj.org/toc/1664-3224It has been reported that several immune cells can release chromatin and granular proteins into extracellular space in response to the stimulation, forming extracellular traps (ETs). The cells involved in the extracellular trap formation are recognized including neutropils, macrophages, basophils, eosinophils, and mast cells. With the development of research related to central nervous system, the role of ETs has been valued in neuroinflammation, blood–brain barrier, and other fields. Meanwhile, it has been found that microglial cells as the resident immune cells of the central nervous system can also release ETs, updating the original understanding. This review aims to clarify the role of the ETs in the central nervous system, especially in neuroinflammation and blood–brain barrier.Xinyan WuHanhai ZengLingxin CaiGao ChenFrontiers Media S.A.articleextracellular trapsneuroinflammationblood–brain barrier (BBB)strokeneurodegenarationCNSImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	extracellular traps neuroinflammation blood–brain barrier (BBB) stroke neurodegenaration CNS Immunologic diseases. Allergy RC581-607
spellingShingle	extracellular traps neuroinflammation blood–brain barrier (BBB) stroke neurodegenaration CNS Immunologic diseases. Allergy RC581-607 Xinyan Wu Hanhai Zeng Lingxin Cai Gao Chen Role of the Extracellular Traps in Central Nervous System
description	It has been reported that several immune cells can release chromatin and granular proteins into extracellular space in response to the stimulation, forming extracellular traps (ETs). The cells involved in the extracellular trap formation are recognized including neutropils, macrophages, basophils, eosinophils, and mast cells. With the development of research related to central nervous system, the role of ETs has been valued in neuroinflammation, blood–brain barrier, and other fields. Meanwhile, it has been found that microglial cells as the resident immune cells of the central nervous system can also release ETs, updating the original understanding. This review aims to clarify the role of the ETs in the central nervous system, especially in neuroinflammation and blood–brain barrier.
format	article
author	Xinyan Wu Hanhai Zeng Lingxin Cai Gao Chen
author_facet	Xinyan Wu Hanhai Zeng Lingxin Cai Gao Chen
author_sort	Xinyan Wu
title	Role of the Extracellular Traps in Central Nervous System
title_short	Role of the Extracellular Traps in Central Nervous System
title_full	Role of the Extracellular Traps in Central Nervous System
title_fullStr	Role of the Extracellular Traps in Central Nervous System
title_full_unstemmed	Role of the Extracellular Traps in Central Nervous System
title_sort	role of the extracellular traps in central nervous system
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c890f94a0d6a4c68951ac1d4ffbed621
work_keys_str_mv	AT xinyanwu roleoftheextracellulartrapsincentralnervoussystem AT hanhaizeng roleoftheextracellulartrapsincentralnervoussystem AT lingxincai roleoftheextracellulartrapsincentralnervoussystem AT gaochen roleoftheextracellulartrapsincentralnervoussystem
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Role of the Extracellular Traps in Central Nervous System

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