ELMO1 signaling is a promoter of osteoclast function and bone loss

Osteoporosis and bone fractures affect millions of patients worldwide and are often due to increased bone resorption. Here the authors identify the cytoplasmic protein ELMO1 as an important ‘signaling node’ promoting the bone resorption function of osteoclasts.

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Autores principales:	Sanja Arandjelovic, Justin S. A. Perry, Ming Zhou, Adam Ceroi, Igor Smirnov, Scott F. Walk, Laura S. Shankman, Isabelle Cambré, Suna Onengut-Gumuscu, Dirk Elewaut, Thomas P. Conrads, Kodi S. Ravichandran
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c891c2231fd74501bad6e2537e8eceb6
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spelling	oai:doaj.org-article:c891c2231fd74501bad6e2537e8eceb62021-12-02T18:00:08ZELMO1 signaling is a promoter of osteoclast function and bone loss10.1038/s41467-021-25239-62041-1723https://doaj.org/article/c891c2231fd74501bad6e2537e8eceb62021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25239-6https://doaj.org/toc/2041-1723Osteoporosis and bone fractures affect millions of patients worldwide and are often due to increased bone resorption. Here the authors identify the cytoplasmic protein ELMO1 as an important ‘signaling node’ promoting the bone resorption function of osteoclasts.Sanja ArandjelovicJustin S. A. PerryMing ZhouAdam CeroiIgor SmirnovScott F. WalkLaura S. ShankmanIsabelle CambréSuna Onengut-GumuscuDirk ElewautThomas P. ConradsKodi S. RavichandranNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sanja Arandjelovic Justin S. A. Perry Ming Zhou Adam Ceroi Igor Smirnov Scott F. Walk Laura S. Shankman Isabelle Cambré Suna Onengut-Gumuscu Dirk Elewaut Thomas P. Conrads Kodi S. Ravichandran ELMO1 signaling is a promoter of osteoclast function and bone loss
description	Osteoporosis and bone fractures affect millions of patients worldwide and are often due to increased bone resorption. Here the authors identify the cytoplasmic protein ELMO1 as an important ‘signaling node’ promoting the bone resorption function of osteoclasts.
format	article
author	Sanja Arandjelovic Justin S. A. Perry Ming Zhou Adam Ceroi Igor Smirnov Scott F. Walk Laura S. Shankman Isabelle Cambré Suna Onengut-Gumuscu Dirk Elewaut Thomas P. Conrads Kodi S. Ravichandran
author_facet	Sanja Arandjelovic Justin S. A. Perry Ming Zhou Adam Ceroi Igor Smirnov Scott F. Walk Laura S. Shankman Isabelle Cambré Suna Onengut-Gumuscu Dirk Elewaut Thomas P. Conrads Kodi S. Ravichandran
author_sort	Sanja Arandjelovic
title	ELMO1 signaling is a promoter of osteoclast function and bone loss
title_short	ELMO1 signaling is a promoter of osteoclast function and bone loss
title_full	ELMO1 signaling is a promoter of osteoclast function and bone loss
title_fullStr	ELMO1 signaling is a promoter of osteoclast function and bone loss
title_full_unstemmed	ELMO1 signaling is a promoter of osteoclast function and bone loss
title_sort	elmo1 signaling is a promoter of osteoclast function and bone loss
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c891c2231fd74501bad6e2537e8eceb6
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ELMO1 signaling is a promoter of osteoclast function and bone loss

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