Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation

The ubiquitylation of histone H2B on lysine 120 is an important modification with roles in a diverse range of nuclear processes. Here, the authors use 'designer' chromatin to show that H2B-ub orients hDot1L into the correct position for activation.

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Autores principales:	Linjiao Zhou, Matthew T. Holt, Nami Ohashi, Aishan Zhao, Manuel M. Müller, Boyuan Wang, Tom W. Muir
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c8971f0fedfb44acb73222b3980cc7bc
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spelling	oai:doaj.org-article:c8971f0fedfb44acb73222b3980cc7bc2021-12-02T16:56:47ZEvidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation10.1038/ncomms105892041-1723https://doaj.org/article/c8971f0fedfb44acb73222b3980cc7bc2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10589https://doaj.org/toc/2041-1723The ubiquitylation of histone H2B on lysine 120 is an important modification with roles in a diverse range of nuclear processes. Here, the authors use 'designer' chromatin to show that H2B-ub orients hDot1L into the correct position for activation.Linjiao ZhouMatthew T. HoltNami OhashiAishan ZhaoManuel M. MüllerBoyuan WangTom W. MuirNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Linjiao Zhou Matthew T. Holt Nami Ohashi Aishan Zhao Manuel M. Müller Boyuan Wang Tom W. Muir Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation
description	The ubiquitylation of histone H2B on lysine 120 is an important modification with roles in a diverse range of nuclear processes. Here, the authors use 'designer' chromatin to show that H2B-ub orients hDot1L into the correct position for activation.
format	article
author	Linjiao Zhou Matthew T. Holt Nami Ohashi Aishan Zhao Manuel M. Müller Boyuan Wang Tom W. Muir
author_facet	Linjiao Zhou Matthew T. Holt Nami Ohashi Aishan Zhao Manuel M. Müller Boyuan Wang Tom W. Muir
author_sort	Linjiao Zhou
title	Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation
title_short	Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation
title_full	Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation
title_fullStr	Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation
title_full_unstemmed	Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation
title_sort	evidence that ubiquitylated h2b corrals hdot1l on the nucleosomal surface to induce h3k79 methylation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c8971f0fedfb44acb73222b3980cc7bc
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Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation

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