Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice

It is believed that the bulk of cerebrospinal fluid (CSF) drains through arachnoid projections from the subarachnoid space to the dural venous sinuses. Here the authors show that the major outflow pathway for CSF in mice are lymphatic vessels and that this drainage decreases as the mice age.

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Autores principales:	Qiaoli Ma, Benjamin V. Ineichen, Michael Detmar, Steven T. Proulx
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c89920c210354bafbfed2555a5f8bed8
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spelling	oai:doaj.org-article:c89920c210354bafbfed2555a5f8bed82021-12-02T14:42:09ZOutflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice10.1038/s41467-017-01484-62041-1723https://doaj.org/article/c89920c210354bafbfed2555a5f8bed82017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01484-6https://doaj.org/toc/2041-1723It is believed that the bulk of cerebrospinal fluid (CSF) drains through arachnoid projections from the subarachnoid space to the dural venous sinuses. Here the authors show that the major outflow pathway for CSF in mice are lymphatic vessels and that this drainage decreases as the mice age.Qiaoli MaBenjamin V. IneichenMichael DetmarSteven T. ProulxNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qiaoli Ma Benjamin V. Ineichen Michael Detmar Steven T. Proulx Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice
description	It is believed that the bulk of cerebrospinal fluid (CSF) drains through arachnoid projections from the subarachnoid space to the dural venous sinuses. Here the authors show that the major outflow pathway for CSF in mice are lymphatic vessels and that this drainage decreases as the mice age.
format	article
author	Qiaoli Ma Benjamin V. Ineichen Michael Detmar Steven T. Proulx
author_facet	Qiaoli Ma Benjamin V. Ineichen Michael Detmar Steven T. Proulx
author_sort	Qiaoli Ma
title	Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice
title_short	Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice
title_full	Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice
title_fullStr	Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice
title_full_unstemmed	Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice
title_sort	outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c89920c210354bafbfed2555a5f8bed8
work_keys_str_mv	AT qiaolima outflowofcerebrospinalfluidispredominantlythroughlymphaticvesselsandisreducedinagedmice AT benjaminvineichen outflowofcerebrospinalfluidispredominantlythroughlymphaticvesselsandisreducedinagedmice AT michaeldetmar outflowofcerebrospinalfluidispredominantlythroughlymphaticvesselsandisreducedinagedmice AT steventproulx outflowofcerebrospinalfluidispredominantlythroughlymphaticvesselsandisreducedinagedmice
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Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice

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