Fetal Undernutrition Programming, Sympathetic Nerve Activity, and Arterial Hypertension Development

A wealth of evidence showed that low birth weight is associated with environmental disruption during gestation, triggering embryotic or fetal adaptations and increasing the susceptibility of progeny to non-communicable diseases, including metabolic and cardiovascular diseases, obesity, and arterial...

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Autores principales:	Vinícius Schiavinatto Mariano, Patrícia Aline Boer, José Antônio Rocha Gontijo
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	maternal low-protein diet catecholamines fetal programming sympathetic nervous system arterial hypertension Physiology QP1-981
Acceso en línea:	https://doaj.org/article/c89cbd86aa1d4ea899b8ae7063a8071f
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spelling	oai:doaj.org-article:c89cbd86aa1d4ea899b8ae7063a8071f2021-11-17T07:01:11ZFetal Undernutrition Programming, Sympathetic Nerve Activity, and Arterial Hypertension Development1664-042X10.3389/fphys.2021.704819https://doaj.org/article/c89cbd86aa1d4ea899b8ae7063a8071f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.704819/fullhttps://doaj.org/toc/1664-042XA wealth of evidence showed that low birth weight is associated with environmental disruption during gestation, triggering embryotic or fetal adaptations and increasing the susceptibility of progeny to non-communicable diseases, including metabolic and cardiovascular diseases, obesity, and arterial hypertension. In addition, dietary disturbance during pregnancy in animal models has highlighted mechanisms that involve the genesis of arterial hypertension, particularly severe maternal low-protein intake (LP). Functional studies demonstrated that maternal low-protein intake leads to the renal decrease of sodium excretion and the dysfunction of the renin-angiotensin-aldosterone system signaling of LP offspring. The antinatriuretic effect is accentuated by a reduced number of nephron units and glomerulosclerosis, which are critical in establishing arterial hypertension phenotype. Also, in this way, studies have shown that the overactivity of the central and peripheral sympathetic nervous system occurs due to reduced sensory (afferent) renal nerve activity. As a result of this reciprocal and abnormal renorenal reflex, there is an enhanced tubule sodium proximal sodium reabsorption, which, at least in part, contributes directly to arterial hypertension development in some of the programmed models. A recent study has observed that significant changes in adrenal medulla secretion could be involved in the pathophysiological process of increasing blood pressure. Thus, this review aims to compile studies that link the central and peripheral sympathetic system activity mechanisms on water and salt handle and blood pressure control in the maternal protein-restricted offspring. Besides, these pathophysiological mechanisms mainly may involve the modulation of neurokinins and catecholamines pathways.Vinícius Schiavinatto MarianoPatrícia Aline BoerJosé Antônio Rocha GontijoFrontiers Media S.A.articlematernal low-protein dietcatecholaminesfetal programmingsympathetic nervous systemarterial hypertensionPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	maternal low-protein diet catecholamines fetal programming sympathetic nervous system arterial hypertension Physiology QP1-981
spellingShingle	maternal low-protein diet catecholamines fetal programming sympathetic nervous system arterial hypertension Physiology QP1-981 Vinícius Schiavinatto Mariano Patrícia Aline Boer José Antônio Rocha Gontijo Fetal Undernutrition Programming, Sympathetic Nerve Activity, and Arterial Hypertension Development
description	A wealth of evidence showed that low birth weight is associated with environmental disruption during gestation, triggering embryotic or fetal adaptations and increasing the susceptibility of progeny to non-communicable diseases, including metabolic and cardiovascular diseases, obesity, and arterial hypertension. In addition, dietary disturbance during pregnancy in animal models has highlighted mechanisms that involve the genesis of arterial hypertension, particularly severe maternal low-protein intake (LP). Functional studies demonstrated that maternal low-protein intake leads to the renal decrease of sodium excretion and the dysfunction of the renin-angiotensin-aldosterone system signaling of LP offspring. The antinatriuretic effect is accentuated by a reduced number of nephron units and glomerulosclerosis, which are critical in establishing arterial hypertension phenotype. Also, in this way, studies have shown that the overactivity of the central and peripheral sympathetic nervous system occurs due to reduced sensory (afferent) renal nerve activity. As a result of this reciprocal and abnormal renorenal reflex, there is an enhanced tubule sodium proximal sodium reabsorption, which, at least in part, contributes directly to arterial hypertension development in some of the programmed models. A recent study has observed that significant changes in adrenal medulla secretion could be involved in the pathophysiological process of increasing blood pressure. Thus, this review aims to compile studies that link the central and peripheral sympathetic system activity mechanisms on water and salt handle and blood pressure control in the maternal protein-restricted offspring. Besides, these pathophysiological mechanisms mainly may involve the modulation of neurokinins and catecholamines pathways.
format	article
author	Vinícius Schiavinatto Mariano Patrícia Aline Boer José Antônio Rocha Gontijo
author_facet	Vinícius Schiavinatto Mariano Patrícia Aline Boer José Antônio Rocha Gontijo
author_sort	Vinícius Schiavinatto Mariano
title	Fetal Undernutrition Programming, Sympathetic Nerve Activity, and Arterial Hypertension Development
title_short	Fetal Undernutrition Programming, Sympathetic Nerve Activity, and Arterial Hypertension Development
title_full	Fetal Undernutrition Programming, Sympathetic Nerve Activity, and Arterial Hypertension Development
title_fullStr	Fetal Undernutrition Programming, Sympathetic Nerve Activity, and Arterial Hypertension Development
title_full_unstemmed	Fetal Undernutrition Programming, Sympathetic Nerve Activity, and Arterial Hypertension Development
title_sort	fetal undernutrition programming, sympathetic nerve activity, and arterial hypertension development
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c89cbd86aa1d4ea899b8ae7063a8071f
work_keys_str_mv	AT viniciusschiavinattomariano fetalundernutritionprogrammingsympatheticnerveactivityandarterialhypertensiondevelopment AT patriciaalineboer fetalundernutritionprogrammingsympatheticnerveactivityandarterialhypertensiondevelopment AT joseantoniorochagontijo fetalundernutritionprogrammingsympatheticnerveactivityandarterialhypertensiondevelopment
_version_	1718425889004322816

Fetal Undernutrition Programming, Sympathetic Nerve Activity, and Arterial Hypertension Development

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