CTCF driven TERRA transcription facilitates completion of telomere DNA replication

TERRA RNA is involved in maintaining stability during telomere repeat replication. Here the authors, by using CRISPR/Cas9, mutate CTCF-binding sites at start site of TERRA transcripts and find that subtelomeric CTCF facilitates telomeric DNA replication by promoting TERRA transcription.

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Autores principales:	Kate Beishline, Olga Vladimirova, Stephen Tutton, Zhuo Wang, Zhong Deng, Paul M. Lieberman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c89d12abd4c04e588a11fd3e293fb27e
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spelling	oai:doaj.org-article:c89d12abd4c04e588a11fd3e293fb27e2021-12-02T15:37:00ZCTCF driven TERRA transcription facilitates completion of telomere DNA replication10.1038/s41467-017-02212-w2041-1723https://doaj.org/article/c89d12abd4c04e588a11fd3e293fb27e2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02212-whttps://doaj.org/toc/2041-1723TERRA RNA is involved in maintaining stability during telomere repeat replication. Here the authors, by using CRISPR/Cas9, mutate CTCF-binding sites at start site of TERRA transcripts and find that subtelomeric CTCF facilitates telomeric DNA replication by promoting TERRA transcription.Kate BeishlineOlga VladimirovaStephen TuttonZhuo WangZhong DengPaul M. LiebermanNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kate Beishline Olga Vladimirova Stephen Tutton Zhuo Wang Zhong Deng Paul M. Lieberman CTCF driven TERRA transcription facilitates completion of telomere DNA replication
description	TERRA RNA is involved in maintaining stability during telomere repeat replication. Here the authors, by using CRISPR/Cas9, mutate CTCF-binding sites at start site of TERRA transcripts and find that subtelomeric CTCF facilitates telomeric DNA replication by promoting TERRA transcription.
format	article
author	Kate Beishline Olga Vladimirova Stephen Tutton Zhuo Wang Zhong Deng Paul M. Lieberman
author_facet	Kate Beishline Olga Vladimirova Stephen Tutton Zhuo Wang Zhong Deng Paul M. Lieberman
author_sort	Kate Beishline
title	CTCF driven TERRA transcription facilitates completion of telomere DNA replication
title_short	CTCF driven TERRA transcription facilitates completion of telomere DNA replication
title_full	CTCF driven TERRA transcription facilitates completion of telomere DNA replication
title_fullStr	CTCF driven TERRA transcription facilitates completion of telomere DNA replication
title_full_unstemmed	CTCF driven TERRA transcription facilitates completion of telomere DNA replication
title_sort	ctcf driven terra transcription facilitates completion of telomere dna replication
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c89d12abd4c04e588a11fd3e293fb27e
work_keys_str_mv	AT katebeishline ctcfdriventerratranscriptionfacilitatescompletionoftelomerednareplication AT olgavladimirova ctcfdriventerratranscriptionfacilitatescompletionoftelomerednareplication AT stephentutton ctcfdriventerratranscriptionfacilitatescompletionoftelomerednareplication AT zhuowang ctcfdriventerratranscriptionfacilitatescompletionoftelomerednareplication AT zhongdeng ctcfdriventerratranscriptionfacilitatescompletionoftelomerednareplication AT paulmlieberman ctcfdriventerratranscriptionfacilitatescompletionoftelomerednareplication
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CTCF driven TERRA transcription facilitates completion of telomere DNA replication

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