The anti-sigma factor RsrA responds to oxidative stress by reburying its hydrophobic core
Counteracting oxidative stress is essential in all organisms. Here, the authors outline a mechanism used by actinomycete bacteria in which oxidation of zinc-binding RsrA blocks its interaction with σR by sequestering hydrophobic residues used to bind σRwithin its own core.
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Nature Portfolio
2016
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oai:doaj.org-article:c89d901e44ac441eb22442e5e5cd39b32021-12-02T14:40:13ZThe anti-sigma factor RsrA responds to oxidative stress by reburying its hydrophobic core10.1038/ncomms121942041-1723https://doaj.org/article/c89d901e44ac441eb22442e5e5cd39b32016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12194https://doaj.org/toc/2041-1723Counteracting oxidative stress is essential in all organisms. Here, the authors outline a mechanism used by actinomycete bacteria in which oxidation of zinc-binding RsrA blocks its interaction with σR by sequestering hydrophobic residues used to bind σRwithin its own core.Karthik V. RajasekarKonrad ZdanowskiJun YanJonathan T. S. HopperMarie-Louise R. FrancisColin SeepersadConnor SharpLudovic PecqueurJörn M. WernerCarol V. RobinsonShabaz MohammedJennifer R. PottsColin KleanthousNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Karthik V. Rajasekar Konrad Zdanowski Jun Yan Jonathan T. S. Hopper Marie-Louise R. Francis Colin Seepersad Connor Sharp Ludovic Pecqueur Jörn M. Werner Carol V. Robinson Shabaz Mohammed Jennifer R. Potts Colin Kleanthous The anti-sigma factor RsrA responds to oxidative stress by reburying its hydrophobic core |
| description |
Counteracting oxidative stress is essential in all organisms. Here, the authors outline a mechanism used by actinomycete bacteria in which oxidation of zinc-binding RsrA blocks its interaction with σR by sequestering hydrophobic residues used to bind σRwithin its own core. |
| format |
article |
| author |
Karthik V. Rajasekar Konrad Zdanowski Jun Yan Jonathan T. S. Hopper Marie-Louise R. Francis Colin Seepersad Connor Sharp Ludovic Pecqueur Jörn M. Werner Carol V. Robinson Shabaz Mohammed Jennifer R. Potts Colin Kleanthous |
| author_facet |
Karthik V. Rajasekar Konrad Zdanowski Jun Yan Jonathan T. S. Hopper Marie-Louise R. Francis Colin Seepersad Connor Sharp Ludovic Pecqueur Jörn M. Werner Carol V. Robinson Shabaz Mohammed Jennifer R. Potts Colin Kleanthous |
| author_sort |
Karthik V. Rajasekar |
| title |
The anti-sigma factor RsrA responds to oxidative stress by reburying its hydrophobic core |
| title_short |
The anti-sigma factor RsrA responds to oxidative stress by reburying its hydrophobic core |
| title_full |
The anti-sigma factor RsrA responds to oxidative stress by reburying its hydrophobic core |
| title_fullStr |
The anti-sigma factor RsrA responds to oxidative stress by reburying its hydrophobic core |
| title_full_unstemmed |
The anti-sigma factor RsrA responds to oxidative stress by reburying its hydrophobic core |
| title_sort |
anti-sigma factor rsra responds to oxidative stress by reburying its hydrophobic core |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/c89d901e44ac441eb22442e5e5cd39b3 |
| work_keys_str_mv |
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1718390383973498880 |