IRF8-dependent molecular complexes control the Th9 transcriptional program

IRF8-dependent molecular complexes control the Th9 transcriptional program

Interferon regulatory factors IRF regulate lymphoid development, but the specific function of IRF8 in helper T-cell polarization is unclear. Here the authors show that IRF8 forms a complex with IRF4, PU.1 and BATF to modulate the Th9 transcription program and expression of IL-4 and IL-9.

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Autores principales: Etienne Humblin, Marion Thibaudin, Fanny Chalmin, Valentin Derangère, Emeric Limagne, Corentin Richard, Richard A. Flavell, Sandy Chevrier, Sylvain Ladoire, Hélène Berger, Romain Boidot, Lionel Apetoh, Frédérique Végran, François Ghiringhelli
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/c89db68f04144f65900b4fd006ab4604
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spelling oai:doaj.org-article:c89db68f04144f65900b4fd006ab46042021-12-02T17:01:18ZIRF8-dependent molecular complexes control the Th9 transcriptional program10.1038/s41467-017-01070-w2041-1723https://doaj.org/article/c89db68f04144f65900b4fd006ab46042017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01070-whttps://doaj.org/toc/2041-1723Interferon regulatory factors IRF regulate lymphoid development, but the specific function of IRF8 in helper T-cell polarization is unclear. Here the authors show that IRF8 forms a complex with IRF4, PU.1 and BATF to modulate the Th9 transcription program and expression of IL-4 and IL-9.Etienne HumblinMarion ThibaudinFanny ChalminValentin DerangèreEmeric LimagneCorentin RichardRichard A. FlavellSandy ChevrierSylvain LadoireHélène BergerRomain BoidotLionel ApetohFrédérique VégranFrançois GhiringhelliNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Etienne Humblin
Marion Thibaudin
Fanny Chalmin
Valentin Derangère
Emeric Limagne
Corentin Richard
Richard A. Flavell
Sandy Chevrier
Sylvain Ladoire
Hélène Berger
Romain Boidot
Lionel Apetoh
Frédérique Végran
François Ghiringhelli
IRF8-dependent molecular complexes control the Th9 transcriptional program
description Interferon regulatory factors IRF regulate lymphoid development, but the specific function of IRF8 in helper T-cell polarization is unclear. Here the authors show that IRF8 forms a complex with IRF4, PU.1 and BATF to modulate the Th9 transcription program and expression of IL-4 and IL-9.
format article
author Etienne Humblin
Marion Thibaudin
Fanny Chalmin
Valentin Derangère
Emeric Limagne
Corentin Richard
Richard A. Flavell
Sandy Chevrier
Sylvain Ladoire
Hélène Berger
Romain Boidot
Lionel Apetoh
Frédérique Végran
François Ghiringhelli
author_facet Etienne Humblin
Marion Thibaudin
Fanny Chalmin
Valentin Derangère
Emeric Limagne
Corentin Richard
Richard A. Flavell
Sandy Chevrier
Sylvain Ladoire
Hélène Berger
Romain Boidot
Lionel Apetoh
Frédérique Végran
François Ghiringhelli
author_sort Etienne Humblin
title IRF8-dependent molecular complexes control the Th9 transcriptional program
title_short IRF8-dependent molecular complexes control the Th9 transcriptional program
title_full IRF8-dependent molecular complexes control the Th9 transcriptional program
title_fullStr IRF8-dependent molecular complexes control the Th9 transcriptional program
title_full_unstemmed IRF8-dependent molecular complexes control the Th9 transcriptional program
title_sort irf8-dependent molecular complexes control the th9 transcriptional program
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/c89db68f04144f65900b4fd006ab4604
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