Risk management in an anticancer drug preparation unit: use of Preliminary Risk Analysis method and application to the preparation process

Preparation of injectable anticancer drugs in hospital pharmacies, in particular of cytotoxics, is a high-risk activity. We used Preliminary Risk Analysis (PRA) to analyse the risks in the different steps of our anticancer drug circuit, including the preparation step (PRA1). Then, to prepare an impo...

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Autores principales:	Gagaille Marie-Pauline, Pieragostini Rémi, Girault Elise, Touil Yacine, Chalopin Marie, Besse Michael, Pons-Kerjean Nathalie
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	anticancer drug circuit cytotoxics injectable preparations risk mapping subcontracting team manage-ment Therapeutics. Pharmacology RM1-950 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/c89f87e786e4461280d8d39830554c79
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spelling	oai:doaj.org-article:c89f87e786e4461280d8d39830554c792021-12-05T14:11:02ZRisk management in an anticancer drug preparation unit: use of Preliminary Risk Analysis method and application to the preparation process2365-24112365-242X10.1515/pthp-2021-0001https://doaj.org/article/c89f87e786e4461280d8d39830554c792021-10-01T00:00:00Zhttps://doi.org/10.1515/pthp-2021-0001https://doaj.org/toc/2365-2411https://doaj.org/toc/2365-242XPreparation of injectable anticancer drugs in hospital pharmacies, in particular of cytotoxics, is a high-risk activity. We used Preliminary Risk Analysis (PRA) to analyse the risks in the different steps of our anticancer drug circuit, including the preparation step (PRA1). Then, to prepare an important change in management of the circuit with the software Chimio® (pooling of three databases for subcontracting), we repeated the analysis of preparation step (PRA2). PRA is known to be time and resource consuming. To overcome this, we developed a strict organisational framework to perform the analysis within a reasonable amount of time. We present the PRA method including its practical implementation, and its application to the anticancer drug preparation process, before and after pooling of Chimio® databases.Gagaille Marie-PaulinePieragostini RémiGirault EliseTouil YacineChalopin MarieBesse MichaelPons-Kerjean NathalieDe Gruyterarticleanticancer drug circuitcytotoxicsinjectable preparationsrisk mappingsubcontractingteam manage-mentTherapeutics. PharmacologyRM1-950Pharmaceutical industryHD9665-9675ENPharmaceutical Technology in Hospital Pharmacy, Vol 6, Iss 1, Pp 901-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	anticancer drug circuit cytotoxics injectable preparations risk mapping subcontracting team manage-ment Therapeutics. Pharmacology RM1-950 Pharmaceutical industry HD9665-9675
spellingShingle	anticancer drug circuit cytotoxics injectable preparations risk mapping subcontracting team manage-ment Therapeutics. Pharmacology RM1-950 Pharmaceutical industry HD9665-9675 Gagaille Marie-Pauline Pieragostini Rémi Girault Elise Touil Yacine Chalopin Marie Besse Michael Pons-Kerjean Nathalie Risk management in an anticancer drug preparation unit: use of Preliminary Risk Analysis method and application to the preparation process
description	Preparation of injectable anticancer drugs in hospital pharmacies, in particular of cytotoxics, is a high-risk activity. We used Preliminary Risk Analysis (PRA) to analyse the risks in the different steps of our anticancer drug circuit, including the preparation step (PRA1). Then, to prepare an important change in management of the circuit with the software Chimio® (pooling of three databases for subcontracting), we repeated the analysis of preparation step (PRA2). PRA is known to be time and resource consuming. To overcome this, we developed a strict organisational framework to perform the analysis within a reasonable amount of time. We present the PRA method including its practical implementation, and its application to the anticancer drug preparation process, before and after pooling of Chimio® databases.
format	article
author	Gagaille Marie-Pauline Pieragostini Rémi Girault Elise Touil Yacine Chalopin Marie Besse Michael Pons-Kerjean Nathalie
author_facet	Gagaille Marie-Pauline Pieragostini Rémi Girault Elise Touil Yacine Chalopin Marie Besse Michael Pons-Kerjean Nathalie
author_sort	Gagaille Marie-Pauline
title	Risk management in an anticancer drug preparation unit: use of Preliminary Risk Analysis method and application to the preparation process
title_short	Risk management in an anticancer drug preparation unit: use of Preliminary Risk Analysis method and application to the preparation process
title_full	Risk management in an anticancer drug preparation unit: use of Preliminary Risk Analysis method and application to the preparation process
title_fullStr	Risk management in an anticancer drug preparation unit: use of Preliminary Risk Analysis method and application to the preparation process
title_full_unstemmed	Risk management in an anticancer drug preparation unit: use of Preliminary Risk Analysis method and application to the preparation process
title_sort	risk management in an anticancer drug preparation unit: use of preliminary risk analysis method and application to the preparation process
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/c89f87e786e4461280d8d39830554c79
work_keys_str_mv	AT gagaillemariepauline riskmanagementinananticancerdrugpreparationunituseofpreliminaryriskanalysismethodandapplicationtothepreparationprocess AT pieragostiniremi riskmanagementinananticancerdrugpreparationunituseofpreliminaryriskanalysismethodandapplicationtothepreparationprocess AT giraultelise riskmanagementinananticancerdrugpreparationunituseofpreliminaryriskanalysismethodandapplicationtothepreparationprocess AT touilyacine riskmanagementinananticancerdrugpreparationunituseofpreliminaryriskanalysismethodandapplicationtothepreparationprocess AT chalopinmarie riskmanagementinananticancerdrugpreparationunituseofpreliminaryriskanalysismethodandapplicationtothepreparationprocess AT bessemichael riskmanagementinananticancerdrugpreparationunituseofpreliminaryriskanalysismethodandapplicationtothepreparationprocess AT ponskerjeannathalie riskmanagementinananticancerdrugpreparationunituseofpreliminaryriskanalysismethodandapplicationtothepreparationprocess
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Risk management in an anticancer drug preparation unit: use of Preliminary Risk Analysis method and application to the preparation process

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