A COMPARATIVE STUDY OF INSULIN RESISTANCE IN PATIENTS OF POLYCYSTIC OVARY SYNDROME

Objective: To assess the relationship between obesity and insulin resistance in polycystic ovary syndrome affected women. Study Design: Cross sectional comparative study. Place and Duration of Study: Multidisciplinary Lab-I of Department of Biochemistry, Army Medical College, Rawalpindi, in co...

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Main Authors:	Amena Arif, Palvasha Waheed, Robina Anees, Amir Rashid, Saleem Ahmed Khan
Format:	article
Language:	EN
Published:	Army Medical College Rawalpindi 2021
Subjects:	insulin resistance obesity Medicine R Medicine (General) R5-920
Online Access:	https://doaj.org/article/c8a1fd4cc30f445da88b9eaf37bc7f4e
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spelling	oai:doaj.org-article:c8a1fd4cc30f445da88b9eaf37bc7f4e2021-11-23T03:34:15ZA COMPARATIVE STUDY OF INSULIN RESISTANCE IN PATIENTS OF POLYCYSTIC OVARY SYNDROME0030-96482411-8842https://doaj.org/article/c8a1fd4cc30f445da88b9eaf37bc7f4e2021-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2633/3613https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To assess the relationship between obesity and insulin resistance in polycystic ovary syndrome affected women. Study Design: Cross sectional comparative study. Place and Duration of Study: Multidisciplinary Lab-I of Department of Biochemistry, Army Medical College, Rawalpindi, in collaboration with Pakistan Naval Ship Hafeez Hospital, Islamabad from Feb 2018 to Jan 2019. Methodology: One hundred and five selected females (puberty till 25 years of age) were divided into three groups of 35 each. Blood samples were collected an overnight fast (from 8-11 AM). Serum level of insulin was measured and insulin resistance was calculated based on HOMA-IR. Results: HOMA-IR concentrations correlated directly with Basal Metabolic Index, fasting plasma glucose and serum insulin levels. Mean serum insulin level was also elevated in patients with polycystic ovary syndrome (normal weight & overweight) as compared to control subjects (7.4 ± 1.2 mIU/L & 9.1 ± 0.8 mIU/L vs 6.3 ± 1.1 mIU/L; p as 0.003). The insulin resistance was slightly higher in patients with polycystic ovary syndrome as compared to the control subjects (1.4 ± 0.3 & 1.7 ± 0.2 vs. 1.1 ± 0.3; p<0.001). Conclusion: HOMA-IR levels are positively associated with BMI, the intensity of peripheral insulin resistance in polycystic ovary syndrome-affected females, indicating that normal weight, and overweight patients with polycystic ovary syndrome have tendency towards insulin resistance.Amena ArifPalvasha WaheedRobina AneesAmir RashidSaleem Ahmed KhanArmy Medical College Rawalpindiarticleinsulin resistanceobesityMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 5, Pp 1746-1751 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	insulin resistance obesity Medicine R Medicine (General) R5-920
spellingShingle	insulin resistance obesity Medicine R Medicine (General) R5-920 Amena Arif Palvasha Waheed Robina Anees Amir Rashid Saleem Ahmed Khan A COMPARATIVE STUDY OF INSULIN RESISTANCE IN PATIENTS OF POLYCYSTIC OVARY SYNDROME
description	Objective: To assess the relationship between obesity and insulin resistance in polycystic ovary syndrome affected women. Study Design: Cross sectional comparative study. Place and Duration of Study: Multidisciplinary Lab-I of Department of Biochemistry, Army Medical College, Rawalpindi, in collaboration with Pakistan Naval Ship Hafeez Hospital, Islamabad from Feb 2018 to Jan 2019. Methodology: One hundred and five selected females (puberty till 25 years of age) were divided into three groups of 35 each. Blood samples were collected an overnight fast (from 8-11 AM). Serum level of insulin was measured and insulin resistance was calculated based on HOMA-IR. Results: HOMA-IR concentrations correlated directly with Basal Metabolic Index, fasting plasma glucose and serum insulin levels. Mean serum insulin level was also elevated in patients with polycystic ovary syndrome (normal weight & overweight) as compared to control subjects (7.4 ± 1.2 mIU/L & 9.1 ± 0.8 mIU/L vs 6.3 ± 1.1 mIU/L; p as 0.003). The insulin resistance was slightly higher in patients with polycystic ovary syndrome as compared to the control subjects (1.4 ± 0.3 & 1.7 ± 0.2 vs. 1.1 ± 0.3; p<0.001). Conclusion: HOMA-IR levels are positively associated with BMI, the intensity of peripheral insulin resistance in polycystic ovary syndrome-affected females, indicating that normal weight, and overweight patients with polycystic ovary syndrome have tendency towards insulin resistance.
format	article
author	Amena Arif Palvasha Waheed Robina Anees Amir Rashid Saleem Ahmed Khan
author_facet	Amena Arif Palvasha Waheed Robina Anees Amir Rashid Saleem Ahmed Khan
author_sort	Amena Arif
title	A COMPARATIVE STUDY OF INSULIN RESISTANCE IN PATIENTS OF POLYCYSTIC OVARY SYNDROME
title_short	A COMPARATIVE STUDY OF INSULIN RESISTANCE IN PATIENTS OF POLYCYSTIC OVARY SYNDROME
title_full	A COMPARATIVE STUDY OF INSULIN RESISTANCE IN PATIENTS OF POLYCYSTIC OVARY SYNDROME
title_fullStr	A COMPARATIVE STUDY OF INSULIN RESISTANCE IN PATIENTS OF POLYCYSTIC OVARY SYNDROME
title_full_unstemmed	A COMPARATIVE STUDY OF INSULIN RESISTANCE IN PATIENTS OF POLYCYSTIC OVARY SYNDROME
title_sort	comparative study of insulin resistance in patients of polycystic ovary syndrome
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/c8a1fd4cc30f445da88b9eaf37bc7f4e
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A COMPARATIVE STUDY OF INSULIN RESISTANCE IN PATIENTS OF POLYCYSTIC OVARY SYNDROME

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