Temporal Aspects of the Association between Exposure to the World Trade Center Disaster and Risk of Cutaneous Melanoma

Rescue/recovery workers who responded to the World Trade Center (WTC) attacks were exposed to known/suspected carcinogens. Studies have identified a trend toward an elevated risk of cutaneous melanoma in this population; however, few found significant increases. Furthermore, temporal aspects of the...

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Autores principales:	Paolo Boffetta, David G. Goldfarb, Rachel Zeig-Owens, Dana Kristjansson, Jiehui Li, Robert M. Brackbill, Mark R. Farfel, James E. Cone, Janette Yung, Amy R. Kahn, Baozhen Qiao, Maria J. Schymura, Mayris P. Webber, David J. Prezant, Christopher R. Dasaro, Andrew C. Todd, Charles B. Hall
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/c8a36b0aea68482a985704801dcaf6ef
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spelling	oai:doaj.org-article:c8a36b0aea68482a985704801dcaf6ef2021-11-28T04:39:45ZTemporal Aspects of the Association between Exposure to the World Trade Center Disaster and Risk of Cutaneous Melanoma2667-026710.1016/j.xjidi.2021.100063https://doaj.org/article/c8a36b0aea68482a985704801dcaf6ef2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667026721000643https://doaj.org/toc/2667-0267Rescue/recovery workers who responded to the World Trade Center (WTC) attacks were exposed to known/suspected carcinogens. Studies have identified a trend toward an elevated risk of cutaneous melanoma in this population; however, few found significant increases. Furthermore, temporal aspects of the association have not been investigated. A total of 44,540 non-Hispanic White workers from the WTC Combined Rescue/Recovery Cohort were studied between March 12, 2002 and December 31, 2015. Cancer data were obtained through linkages with 13 state registries. Poisson regression was used to estimate hazard ratios and 95% confidence intervals using the New York State population as the reference; change points in hazard ratios were estimated using profile likelihood. We observed 247 incident cases of melanoma. No increase in incidence was detected during 2002–2004. From 2005 to 2015, the hazard ratio was 1.34 (95% confidence interval = 1.18–1.52). A dose‒response relationship was observed by arrival time at the WTC site. Risk was elevated just over 3 years after the attacks. Whereas WTC-related exposures to UVR or other agents might have contributed to this result, exposures other than those at the WTC site, enhanced medical surveillance, and lack of a control group with a similar proportion of rescue/recovery workers cannot be discounted. Our results support continued study of this population for melanoma.Paolo BoffettaDavid G. GoldfarbRachel Zeig-OwensDana KristjanssonJiehui LiRobert M. BrackbillMark R. FarfelJames E. ConeJanette YungAmy R. KahnBaozhen QiaoMaria J. SchymuraMayris P. WebberDavid J. PrezantChristopher R. DasaroAndrew C. ToddCharles B. HallElsevierarticleDermatologyRL1-803ENJID Innovations, Vol 2, Iss 1, Pp 100063- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dermatology RL1-803
spellingShingle	Dermatology RL1-803 Paolo Boffetta David G. Goldfarb Rachel Zeig-Owens Dana Kristjansson Jiehui Li Robert M. Brackbill Mark R. Farfel James E. Cone Janette Yung Amy R. Kahn Baozhen Qiao Maria J. Schymura Mayris P. Webber David J. Prezant Christopher R. Dasaro Andrew C. Todd Charles B. Hall Temporal Aspects of the Association between Exposure to the World Trade Center Disaster and Risk of Cutaneous Melanoma
description	Rescue/recovery workers who responded to the World Trade Center (WTC) attacks were exposed to known/suspected carcinogens. Studies have identified a trend toward an elevated risk of cutaneous melanoma in this population; however, few found significant increases. Furthermore, temporal aspects of the association have not been investigated. A total of 44,540 non-Hispanic White workers from the WTC Combined Rescue/Recovery Cohort were studied between March 12, 2002 and December 31, 2015. Cancer data were obtained through linkages with 13 state registries. Poisson regression was used to estimate hazard ratios and 95% confidence intervals using the New York State population as the reference; change points in hazard ratios were estimated using profile likelihood. We observed 247 incident cases of melanoma. No increase in incidence was detected during 2002–2004. From 2005 to 2015, the hazard ratio was 1.34 (95% confidence interval = 1.18–1.52). A dose‒response relationship was observed by arrival time at the WTC site. Risk was elevated just over 3 years after the attacks. Whereas WTC-related exposures to UVR or other agents might have contributed to this result, exposures other than those at the WTC site, enhanced medical surveillance, and lack of a control group with a similar proportion of rescue/recovery workers cannot be discounted. Our results support continued study of this population for melanoma.
format	article
author	Paolo Boffetta David G. Goldfarb Rachel Zeig-Owens Dana Kristjansson Jiehui Li Robert M. Brackbill Mark R. Farfel James E. Cone Janette Yung Amy R. Kahn Baozhen Qiao Maria J. Schymura Mayris P. Webber David J. Prezant Christopher R. Dasaro Andrew C. Todd Charles B. Hall
author_facet	Paolo Boffetta David G. Goldfarb Rachel Zeig-Owens Dana Kristjansson Jiehui Li Robert M. Brackbill Mark R. Farfel James E. Cone Janette Yung Amy R. Kahn Baozhen Qiao Maria J. Schymura Mayris P. Webber David J. Prezant Christopher R. Dasaro Andrew C. Todd Charles B. Hall
author_sort	Paolo Boffetta
title	Temporal Aspects of the Association between Exposure to the World Trade Center Disaster and Risk of Cutaneous Melanoma
title_short	Temporal Aspects of the Association between Exposure to the World Trade Center Disaster and Risk of Cutaneous Melanoma
title_full	Temporal Aspects of the Association between Exposure to the World Trade Center Disaster and Risk of Cutaneous Melanoma
title_fullStr	Temporal Aspects of the Association between Exposure to the World Trade Center Disaster and Risk of Cutaneous Melanoma
title_full_unstemmed	Temporal Aspects of the Association between Exposure to the World Trade Center Disaster and Risk of Cutaneous Melanoma
title_sort	temporal aspects of the association between exposure to the world trade center disaster and risk of cutaneous melanoma
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/c8a36b0aea68482a985704801dcaf6ef
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Temporal Aspects of the Association between Exposure to the World Trade Center Disaster and Risk of Cutaneous Melanoma

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