The Influence of Supplementation with Zinc in Micro and Nano Forms on the Metabolism of Fatty Acids in Livers of Rats with Breast Cancer

The aim of this study was to investigate the effect of zinc supplementation (in the form of nano or microparticles) on the profile and metabolism of fatty acids in the liver microsomes of rats with induced breast cancer. The activity of desaturases (Δ5, Δ6, Δ9) and the level of cholesterol and its o...

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Autores principales:	Agnieszka Stawarska, Małgorzata Czerwonka, Małgorzata Jelińska, Iga Piasecka, Barbara Bobrowska-Korczak
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Zinc nanoparticles fatty acid metabolism desaturases HETE HODE Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/c8a6c76a295c48808bcbeb81aec4ec01
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spelling	oai:doaj.org-article:c8a6c76a295c48808bcbeb81aec4ec012021-11-25T18:34:25ZThe Influence of Supplementation with Zinc in Micro and Nano Forms on the Metabolism of Fatty Acids in Livers of Rats with Breast Cancer10.3390/nu131138212072-6643https://doaj.org/article/c8a6c76a295c48808bcbeb81aec4ec012021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3821https://doaj.org/toc/2072-6643The aim of this study was to investigate the effect of zinc supplementation (in the form of nano or microparticles) on the profile and metabolism of fatty acids in the liver microsomes of rats with induced breast cancer. The activity of desaturases (Δ5, Δ6, Δ9) and the level of cholesterol and its oxidized derivatives were measured. The aim of this study was also to determine the effect of various forms of zinc supplements on rats that were on 5-, 12- and 15-hydroxyeicosatetraenoic (5-, 12- and 15-HETE) and hydroxyoctadecadienoic (HODE) acids, and the level of prostaglandin E2 (PGE2). Female Spraque-Dawley rats (<i>n</i> = 24) were divided into 2 groups that were supplemented with zinc in the micro form (342 nm) or nano form (99 nm) particles, respectively, and a group with a standard diet (control group). All animals received 7,12-dimethylbenz[a]anthracene twice for the induction of breast cancer. Dietary nano-Zn supplementation increased vaccenic acid content (<i>p</i> = 0.032) and decreased Δ6-desaturase activity (<i>p</i> = 0.006), whereas micro-Zn increased cholesterol (<i>p</i> = 0.006), ∑COPs (total cholesterol-oxidation products) (<i>p</i> = 0.019) and PGE2 (<i>p</i> = 0.028) content. Dietary enrichment with Zn microparticles resulted in lower concentrations of the metabolites 15-, 12- and 5-HETE and HODE. Our study indicates that the effect of zinc supplementation on the metabolism of fatty acids in the liver microsomes under neoplastic conditions depends on the form in which it is administered.Agnieszka StawarskaMałgorzata CzerwonkaMałgorzata JelińskaIga PiaseckaBarbara Bobrowska-KorczakMDPI AGarticleZincnanoparticlesfatty acid metabolismdesaturasesHETEHODENutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3821, p 3821 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Zinc nanoparticles fatty acid metabolism desaturases HETE HODE Nutrition. Foods and food supply TX341-641
spellingShingle	Zinc nanoparticles fatty acid metabolism desaturases HETE HODE Nutrition. Foods and food supply TX341-641 Agnieszka Stawarska Małgorzata Czerwonka Małgorzata Jelińska Iga Piasecka Barbara Bobrowska-Korczak The Influence of Supplementation with Zinc in Micro and Nano Forms on the Metabolism of Fatty Acids in Livers of Rats with Breast Cancer
description	The aim of this study was to investigate the effect of zinc supplementation (in the form of nano or microparticles) on the profile and metabolism of fatty acids in the liver microsomes of rats with induced breast cancer. The activity of desaturases (Δ5, Δ6, Δ9) and the level of cholesterol and its oxidized derivatives were measured. The aim of this study was also to determine the effect of various forms of zinc supplements on rats that were on 5-, 12- and 15-hydroxyeicosatetraenoic (5-, 12- and 15-HETE) and hydroxyoctadecadienoic (HODE) acids, and the level of prostaglandin E2 (PGE2). Female Spraque-Dawley rats (<i>n</i> = 24) were divided into 2 groups that were supplemented with zinc in the micro form (342 nm) or nano form (99 nm) particles, respectively, and a group with a standard diet (control group). All animals received 7,12-dimethylbenz[a]anthracene twice for the induction of breast cancer. Dietary nano-Zn supplementation increased vaccenic acid content (<i>p</i> = 0.032) and decreased Δ6-desaturase activity (<i>p</i> = 0.006), whereas micro-Zn increased cholesterol (<i>p</i> = 0.006), ∑COPs (total cholesterol-oxidation products) (<i>p</i> = 0.019) and PGE2 (<i>p</i> = 0.028) content. Dietary enrichment with Zn microparticles resulted in lower concentrations of the metabolites 15-, 12- and 5-HETE and HODE. Our study indicates that the effect of zinc supplementation on the metabolism of fatty acids in the liver microsomes under neoplastic conditions depends on the form in which it is administered.
format	article
author	Agnieszka Stawarska Małgorzata Czerwonka Małgorzata Jelińska Iga Piasecka Barbara Bobrowska-Korczak
author_facet	Agnieszka Stawarska Małgorzata Czerwonka Małgorzata Jelińska Iga Piasecka Barbara Bobrowska-Korczak
author_sort	Agnieszka Stawarska
title	The Influence of Supplementation with Zinc in Micro and Nano Forms on the Metabolism of Fatty Acids in Livers of Rats with Breast Cancer
title_short	The Influence of Supplementation with Zinc in Micro and Nano Forms on the Metabolism of Fatty Acids in Livers of Rats with Breast Cancer
title_full	The Influence of Supplementation with Zinc in Micro and Nano Forms on the Metabolism of Fatty Acids in Livers of Rats with Breast Cancer
title_fullStr	The Influence of Supplementation with Zinc in Micro and Nano Forms on the Metabolism of Fatty Acids in Livers of Rats with Breast Cancer
title_full_unstemmed	The Influence of Supplementation with Zinc in Micro and Nano Forms on the Metabolism of Fatty Acids in Livers of Rats with Breast Cancer
title_sort	influence of supplementation with zinc in micro and nano forms on the metabolism of fatty acids in livers of rats with breast cancer
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c8a6c76a295c48808bcbeb81aec4ec01
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The Influence of Supplementation with Zinc in Micro and Nano Forms on the Metabolism of Fatty Acids in Livers of Rats with Breast Cancer

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