Development of at-home sample collection logistics for large-scale seroprevalence studies

<h4>Background</h4> Serological studies rely on the recruitment of representative cohorts; however, such efforts are specially complicated by the conditions surrounding the COVID19 pandemic. <h4>Methods</h4> We aimed to design and implement a fully remote methodology for cond...

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Autores principales:	Aishani V. Aatresh, Kate Cummings, Hilary Gerstein, Christopher S. Knight, Andreas Limberopolous, Megan A. Stasi, Alice Bedugnis, Kenneth A. Somberg, Camila T. França, Michael J. Mina
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c8a76ee339634757acc8faf17a1c60f5
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spelling	oai:doaj.org-article:c8a76ee339634757acc8faf17a1c60f52021-11-11T07:14:42ZDevelopment of at-home sample collection logistics for large-scale seroprevalence studies1932-6203https://doaj.org/article/c8a76ee339634757acc8faf17a1c60f52021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568136/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4> Serological studies rely on the recruitment of representative cohorts; however, such efforts are specially complicated by the conditions surrounding the COVID19 pandemic. <h4>Methods</h4> We aimed to design and implement a fully remote methodology for conducting safe serological surveys that also allow for the engagement of representative study populations. <h4>Results</h4> This design was well-received and effective. 2,066 participants ≥18 years old were enrolled, reflecting the ethnic and racial composition of Massachusetts. >70% of them reported being satisfied/extremely satisfied with the online enrollment and at-home self-collection of blood samples. While 18.6% reported some discomfort experienced with the collection process, 72.2% stated that they would be willing to test weekly if enrolled in a long-term study. <h4>Conclusions</h4> High engagement and positive feedback from participants, as well as the quality of self-collected specimens, point to the usefulness of this fully remote, self-collection-based study design for future safer and efficient population-level serological surveys.Aishani V. AatreshKate CummingsHilary GersteinChristopher S. KnightAndreas LimberopolousMegan A. StasiAlice BedugnisKenneth A. SombergCamila T. FrançaMichael J. MinaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aishani V. Aatresh Kate Cummings Hilary Gerstein Christopher S. Knight Andreas Limberopolous Megan A. Stasi Alice Bedugnis Kenneth A. Somberg Camila T. França Michael J. Mina Development of at-home sample collection logistics for large-scale seroprevalence studies
description	<h4>Background</h4> Serological studies rely on the recruitment of representative cohorts; however, such efforts are specially complicated by the conditions surrounding the COVID19 pandemic. <h4>Methods</h4> We aimed to design and implement a fully remote methodology for conducting safe serological surveys that also allow for the engagement of representative study populations. <h4>Results</h4> This design was well-received and effective. 2,066 participants ≥18 years old were enrolled, reflecting the ethnic and racial composition of Massachusetts. >70% of them reported being satisfied/extremely satisfied with the online enrollment and at-home self-collection of blood samples. While 18.6% reported some discomfort experienced with the collection process, 72.2% stated that they would be willing to test weekly if enrolled in a long-term study. <h4>Conclusions</h4> High engagement and positive feedback from participants, as well as the quality of self-collected specimens, point to the usefulness of this fully remote, self-collection-based study design for future safer and efficient population-level serological surveys.
format	article
author	Aishani V. Aatresh Kate Cummings Hilary Gerstein Christopher S. Knight Andreas Limberopolous Megan A. Stasi Alice Bedugnis Kenneth A. Somberg Camila T. França Michael J. Mina
author_facet	Aishani V. Aatresh Kate Cummings Hilary Gerstein Christopher S. Knight Andreas Limberopolous Megan A. Stasi Alice Bedugnis Kenneth A. Somberg Camila T. França Michael J. Mina
author_sort	Aishani V. Aatresh
title	Development of at-home sample collection logistics for large-scale seroprevalence studies
title_short	Development of at-home sample collection logistics for large-scale seroprevalence studies
title_full	Development of at-home sample collection logistics for large-scale seroprevalence studies
title_fullStr	Development of at-home sample collection logistics for large-scale seroprevalence studies
title_full_unstemmed	Development of at-home sample collection logistics for large-scale seroprevalence studies
title_sort	development of at-home sample collection logistics for large-scale seroprevalence studies
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/c8a76ee339634757acc8faf17a1c60f5
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Development of at-home sample collection logistics for large-scale seroprevalence studies

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