Immunomodulatory Potential of the Industrialized <i>Houttuynia cordata</i> Fermentation Product In Vitro and in Wistar Rats

<i>Houttuynia cordata</i> fermentation products (HCFPs) are produced and widely used as dietary supplements for health and immune support. However, the effect on immune function for these products has not been clearly demonstrated. In this study, soluble fractions of the selected HCFP we...

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Autores principales:	Suppawit Utaiwat, Gulsiri Senawong, Kanoknan Khongsukwiwat, Khanutsanan Woranam, Jintana Sattayasai, Thanaset Senawong
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Houttuynia cordata</i> fermentation product immunomodulation immunosuppression Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/c8adf52a526e4ab98298ebed6f0be3c0
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id	oai:doaj.org-article:c8adf52a526e4ab98298ebed6f0be3c0
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spelling	oai:doaj.org-article:c8adf52a526e4ab98298ebed6f0be3c02021-11-25T17:32:56ZImmunomodulatory Potential of the Industrialized <i>Houttuynia cordata</i> Fermentation Product In Vitro and in Wistar Rats10.3390/foods101125822304-8158https://doaj.org/article/c8adf52a526e4ab98298ebed6f0be3c02021-10-01T00:00:00Zhttps://www.mdpi.com/2304-8158/10/11/2582https://doaj.org/toc/2304-8158<i>Houttuynia cordata</i> fermentation products (HCFPs) are produced and widely used as dietary supplements for health and immune support. However, the effect on immune function for these products has not been clearly demonstrated. In this study, soluble fractions of the selected HCFP were used for determination of the immunomodulatory potential, both in vitro and in animal models. Viability and proliferation of rat splenocytes and phagocytic activity of human neutrophils were evaluated. Studies on immunomodulatory effects, including hematological parameters, mitogen-driven lymphocyte proliferation and hemagglutination, were performed in both healthy and immunosuppressed rats. Soluble fraction of the selected HCFP significantly enhanced phagocytic activity of human neutrophils and tended to stimulate splenocyte viability and proliferation. There was no morbidity or mortality for administration of a 14-day regimen of the selected HCFP in both male and female rats. The healthy rats treated with HCFP gained body weight less than the control group, suggesting a reduction in calorie intake. Moreover, low dose of HCFP caused an increased B cell proliferation in ex-vivo, which was related to the increased antibody titer against SRBC in immunosuppressed rats. Our results indicate that the selected HCFP enhances the phagocytic activity of the neutrophils and augments the antibody production in immunosuppressed rats.Suppawit UtaiwatGulsiri SenawongKanoknan KhongsukwiwatKhanutsanan WoranamJintana SattayasaiThanaset SenawongMDPI AGarticle<i>Houttuynia cordata</i>fermentation productimmunomodulationimmunosuppressionChemical technologyTP1-1185ENFoods, Vol 10, Iss 2582, p 2582 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Houttuynia cordata</i> fermentation product immunomodulation immunosuppression Chemical technology TP1-1185
spellingShingle	<i>Houttuynia cordata</i> fermentation product immunomodulation immunosuppression Chemical technology TP1-1185 Suppawit Utaiwat Gulsiri Senawong Kanoknan Khongsukwiwat Khanutsanan Woranam Jintana Sattayasai Thanaset Senawong Immunomodulatory Potential of the Industrialized <i>Houttuynia cordata</i> Fermentation Product In Vitro and in Wistar Rats
description	<i>Houttuynia cordata</i> fermentation products (HCFPs) are produced and widely used as dietary supplements for health and immune support. However, the effect on immune function for these products has not been clearly demonstrated. In this study, soluble fractions of the selected HCFP were used for determination of the immunomodulatory potential, both in vitro and in animal models. Viability and proliferation of rat splenocytes and phagocytic activity of human neutrophils were evaluated. Studies on immunomodulatory effects, including hematological parameters, mitogen-driven lymphocyte proliferation and hemagglutination, were performed in both healthy and immunosuppressed rats. Soluble fraction of the selected HCFP significantly enhanced phagocytic activity of human neutrophils and tended to stimulate splenocyte viability and proliferation. There was no morbidity or mortality for administration of a 14-day regimen of the selected HCFP in both male and female rats. The healthy rats treated with HCFP gained body weight less than the control group, suggesting a reduction in calorie intake. Moreover, low dose of HCFP caused an increased B cell proliferation in ex-vivo, which was related to the increased antibody titer against SRBC in immunosuppressed rats. Our results indicate that the selected HCFP enhances the phagocytic activity of the neutrophils and augments the antibody production in immunosuppressed rats.
format	article
author	Suppawit Utaiwat Gulsiri Senawong Kanoknan Khongsukwiwat Khanutsanan Woranam Jintana Sattayasai Thanaset Senawong
author_facet	Suppawit Utaiwat Gulsiri Senawong Kanoknan Khongsukwiwat Khanutsanan Woranam Jintana Sattayasai Thanaset Senawong
author_sort	Suppawit Utaiwat
title	Immunomodulatory Potential of the Industrialized <i>Houttuynia cordata</i> Fermentation Product In Vitro and in Wistar Rats
title_short	Immunomodulatory Potential of the Industrialized <i>Houttuynia cordata</i> Fermentation Product In Vitro and in Wistar Rats
title_full	Immunomodulatory Potential of the Industrialized <i>Houttuynia cordata</i> Fermentation Product In Vitro and in Wistar Rats
title_fullStr	Immunomodulatory Potential of the Industrialized <i>Houttuynia cordata</i> Fermentation Product In Vitro and in Wistar Rats
title_full_unstemmed	Immunomodulatory Potential of the Industrialized <i>Houttuynia cordata</i> Fermentation Product In Vitro and in Wistar Rats
title_sort	immunomodulatory potential of the industrialized <i>houttuynia cordata</i> fermentation product in vitro and in wistar rats
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c8adf52a526e4ab98298ebed6f0be3c0
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Immunomodulatory Potential of the Industrialized <i>Houttuynia cordata</i> Fermentation Product In Vitro and in Wistar Rats

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