Facilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement.

Cell adhesion molecules and downstream growth factor-dependent signaling are critical for brain development and synaptic plasticity, and they have been linked to cognitive function in adult animals. We have previously developed a mimetic peptide (FGL) from the neural cell adhesion molecule (NCAM) th...

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Autores principales:	Shira Knafo, César Venero, Cristina Sánchez-Puelles, Inmaculada Pereda-Peréz, Ana Franco, Carmen Sandi, Luz M Suárez, José M Solís, Lidia Alonso-Nanclares, Eduardo D Martín, Paula Merino-Serrais, Erika Borcel, Shizhong Li, Yongshuo Chen, Juncal Gonzalez-Soriano, Vladimir Berezin, Elisabeth Bock, Javier Defelipe, José A Esteban
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c8afde1bf0774f8a8e1624331a6f7835
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spelling	oai:doaj.org-article:c8afde1bf0774f8a8e1624331a6f78352021-11-18T05:36:46ZFacilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement.1544-91731545-788510.1371/journal.pbio.1001262https://doaj.org/article/c8afde1bf0774f8a8e1624331a6f78352012-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22363206/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Cell adhesion molecules and downstream growth factor-dependent signaling are critical for brain development and synaptic plasticity, and they have been linked to cognitive function in adult animals. We have previously developed a mimetic peptide (FGL) from the neural cell adhesion molecule (NCAM) that enhances spatial learning and memory in rats. We have now investigated the cellular and molecular basis of this cognitive enhancement, using biochemical, morphological, electrophysiological, and behavioral analyses. We have found that FGL triggers a long-lasting enhancement of synaptic transmission in hippocampal CA1 neurons. This effect is mediated by a facilitated synaptic delivery of AMPA receptors, which is accompanied by enhanced NMDA receptor-dependent long-term potentiation (LTP). Both LTP and cognitive enhancement are mediated by an initial PKC activation, which is followed by persistent CaMKII activation. These results provide a mechanistic link between facilitation of AMPA receptor synaptic delivery and improved hippocampal-dependent learning, induced by a pharmacological cognitive enhancer.Shira KnafoCésar VeneroCristina Sánchez-PuellesInmaculada Pereda-PerézAna FrancoCarmen SandiLuz M SuárezJosé M SolísLidia Alonso-NanclaresEduardo D MartínPaula Merino-SerraisErika BorcelShizhong LiYongshuo ChenJuncal Gonzalez-SorianoVladimir BerezinElisabeth BockJavier DefelipeJosé A EstebanPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 10, Iss 2, p e1001262 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Shira Knafo César Venero Cristina Sánchez-Puelles Inmaculada Pereda-Peréz Ana Franco Carmen Sandi Luz M Suárez José M Solís Lidia Alonso-Nanclares Eduardo D Martín Paula Merino-Serrais Erika Borcel Shizhong Li Yongshuo Chen Juncal Gonzalez-Soriano Vladimir Berezin Elisabeth Bock Javier Defelipe José A Esteban Facilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement.
description	Cell adhesion molecules and downstream growth factor-dependent signaling are critical for brain development and synaptic plasticity, and they have been linked to cognitive function in adult animals. We have previously developed a mimetic peptide (FGL) from the neural cell adhesion molecule (NCAM) that enhances spatial learning and memory in rats. We have now investigated the cellular and molecular basis of this cognitive enhancement, using biochemical, morphological, electrophysiological, and behavioral analyses. We have found that FGL triggers a long-lasting enhancement of synaptic transmission in hippocampal CA1 neurons. This effect is mediated by a facilitated synaptic delivery of AMPA receptors, which is accompanied by enhanced NMDA receptor-dependent long-term potentiation (LTP). Both LTP and cognitive enhancement are mediated by an initial PKC activation, which is followed by persistent CaMKII activation. These results provide a mechanistic link between facilitation of AMPA receptor synaptic delivery and improved hippocampal-dependent learning, induced by a pharmacological cognitive enhancer.
format	article
author	Shira Knafo César Venero Cristina Sánchez-Puelles Inmaculada Pereda-Peréz Ana Franco Carmen Sandi Luz M Suárez José M Solís Lidia Alonso-Nanclares Eduardo D Martín Paula Merino-Serrais Erika Borcel Shizhong Li Yongshuo Chen Juncal Gonzalez-Soriano Vladimir Berezin Elisabeth Bock Javier Defelipe José A Esteban
author_facet	Shira Knafo César Venero Cristina Sánchez-Puelles Inmaculada Pereda-Peréz Ana Franco Carmen Sandi Luz M Suárez José M Solís Lidia Alonso-Nanclares Eduardo D Martín Paula Merino-Serrais Erika Borcel Shizhong Li Yongshuo Chen Juncal Gonzalez-Soriano Vladimir Berezin Elisabeth Bock Javier Defelipe José A Esteban
author_sort	Shira Knafo
title	Facilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement.
title_short	Facilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement.
title_full	Facilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement.
title_fullStr	Facilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement.
title_full_unstemmed	Facilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement.
title_sort	facilitation of ampa receptor synaptic delivery as a molecular mechanism for cognitive enhancement.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/c8afde1bf0774f8a8e1624331a6f7835
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Facilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement.

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