A release-and-capture mechanism generates an essential non-centrosomal microtubule array during tube budding

Non-centrosomal microtubules provide essential functions in many cells, but the mechanisms of their formation are poorly understood. Here, the authors show that during tube formation of the Drosophila salivary glands, microtubules are released from a single active centrosome via katanin, triggering...

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Auteurs principaux:	Ghislain Gillard, Gemma Girdler, Katja Röper
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/c8b3e7abe79a4aa8b40b07f0f81e1857
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spelling	oai:doaj.org-article:c8b3e7abe79a4aa8b40b07f0f81e18572021-12-02T16:10:47ZA release-and-capture mechanism generates an essential non-centrosomal microtubule array during tube budding10.1038/s41467-021-24332-02041-1723https://doaj.org/article/c8b3e7abe79a4aa8b40b07f0f81e18572021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24332-0https://doaj.org/toc/2041-1723Non-centrosomal microtubules provide essential functions in many cells, but the mechanisms of their formation are poorly understood. Here, the authors show that during tube formation of the Drosophila salivary glands, microtubules are released from a single active centrosome via katanin, triggering recruitment of Patronin, and leading to formation of a non-centrosomal network key to the tube invagination process.Ghislain GillardGemma GirdlerKatja RöperNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ghislain Gillard Gemma Girdler Katja Röper A release-and-capture mechanism generates an essential non-centrosomal microtubule array during tube budding
description	Non-centrosomal microtubules provide essential functions in many cells, but the mechanisms of their formation are poorly understood. Here, the authors show that during tube formation of the Drosophila salivary glands, microtubules are released from a single active centrosome via katanin, triggering recruitment of Patronin, and leading to formation of a non-centrosomal network key to the tube invagination process.
format	article
author	Ghislain Gillard Gemma Girdler Katja Röper
author_facet	Ghislain Gillard Gemma Girdler Katja Röper
author_sort	Ghislain Gillard
title	A release-and-capture mechanism generates an essential non-centrosomal microtubule array during tube budding
title_short	A release-and-capture mechanism generates an essential non-centrosomal microtubule array during tube budding
title_full	A release-and-capture mechanism generates an essential non-centrosomal microtubule array during tube budding
title_fullStr	A release-and-capture mechanism generates an essential non-centrosomal microtubule array during tube budding
title_full_unstemmed	A release-and-capture mechanism generates an essential non-centrosomal microtubule array during tube budding
title_sort	release-and-capture mechanism generates an essential non-centrosomal microtubule array during tube budding
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c8b3e7abe79a4aa8b40b07f0f81e1857
work_keys_str_mv	AT ghislaingillard areleaseandcapturemechanismgeneratesanessentialnoncentrosomalmicrotubulearrayduringtubebudding AT gemmagirdler areleaseandcapturemechanismgeneratesanessentialnoncentrosomalmicrotubulearrayduringtubebudding AT katjaroper areleaseandcapturemechanismgeneratesanessentialnoncentrosomalmicrotubulearrayduringtubebudding AT ghislaingillard releaseandcapturemechanismgeneratesanessentialnoncentrosomalmicrotubulearrayduringtubebudding AT gemmagirdler releaseandcapturemechanismgeneratesanessentialnoncentrosomalmicrotubulearrayduringtubebudding AT katjaroper releaseandcapturemechanismgeneratesanessentialnoncentrosomalmicrotubulearrayduringtubebudding
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A release-and-capture mechanism generates an essential non-centrosomal microtubule array during tube budding

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