Intertissue small RNA communication mediates the acquisition and inheritance of hormesis in Caenorhabditis elegans
Okabe et al. show that the miRNA production system in the neuron and the small RNA transport machinery in the intestine are required for the acquisition of hormesis. For its inheritance, both the transport of small RNAs in the germline and the germline Argonaute HRDE-1 complex are needed, highlighti...
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Nature Portfolio
2021
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oai:doaj.org-article:c8b4e77b94f946d6bef7dc612bea48de2021-12-02T14:03:56ZIntertissue small RNA communication mediates the acquisition and inheritance of hormesis in Caenorhabditis elegans10.1038/s42003-021-01692-32399-3642https://doaj.org/article/c8b4e77b94f946d6bef7dc612bea48de2021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01692-3https://doaj.org/toc/2399-3642Okabe et al. show that the miRNA production system in the neuron and the small RNA transport machinery in the intestine are required for the acquisition of hormesis. For its inheritance, both the transport of small RNAs in the germline and the germline Argonaute HRDE-1 complex are needed, highlighting distinct contribution of small RNA systems to hormesis.Emiko OkabeMasaharu UnoSaya KishimotoEisuke NishidaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021) |
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DOAJ |
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Biology (General) QH301-705.5 |
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Biology (General) QH301-705.5 Emiko Okabe Masaharu Uno Saya Kishimoto Eisuke Nishida Intertissue small RNA communication mediates the acquisition and inheritance of hormesis in Caenorhabditis elegans |
description |
Okabe et al. show that the miRNA production system in the neuron and the small RNA transport machinery in the intestine are required for the acquisition of hormesis. For its inheritance, both the transport of small RNAs in the germline and the germline Argonaute HRDE-1 complex are needed, highlighting distinct contribution of small RNA systems to hormesis. |
format |
article |
author |
Emiko Okabe Masaharu Uno Saya Kishimoto Eisuke Nishida |
author_facet |
Emiko Okabe Masaharu Uno Saya Kishimoto Eisuke Nishida |
author_sort |
Emiko Okabe |
title |
Intertissue small RNA communication mediates the acquisition and inheritance of hormesis in Caenorhabditis elegans |
title_short |
Intertissue small RNA communication mediates the acquisition and inheritance of hormesis in Caenorhabditis elegans |
title_full |
Intertissue small RNA communication mediates the acquisition and inheritance of hormesis in Caenorhabditis elegans |
title_fullStr |
Intertissue small RNA communication mediates the acquisition and inheritance of hormesis in Caenorhabditis elegans |
title_full_unstemmed |
Intertissue small RNA communication mediates the acquisition and inheritance of hormesis in Caenorhabditis elegans |
title_sort |
intertissue small rna communication mediates the acquisition and inheritance of hormesis in caenorhabditis elegans |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/c8b4e77b94f946d6bef7dc612bea48de |
work_keys_str_mv |
AT emikookabe intertissuesmallrnacommunicationmediatestheacquisitionandinheritanceofhormesisincaenorhabditiselegans AT masaharuuno intertissuesmallrnacommunicationmediatestheacquisitionandinheritanceofhormesisincaenorhabditiselegans AT sayakishimoto intertissuesmallrnacommunicationmediatestheacquisitionandinheritanceofhormesisincaenorhabditiselegans AT eisukenishida intertissuesmallrnacommunicationmediatestheacquisitionandinheritanceofhormesisincaenorhabditiselegans |
_version_ |
1718392048846897152 |