Plastic roles of pericytes in the blood–retinal barrier

Blood-retinal barrier (BRB) is composed of tightly connected endothelium and supporting pericytes and glia. Here, the authors show that pericytes are crucial for BRB buildup during retinal development and its maintenance in adult retinas in response to VEGF-A-induced endothelial sensitization by reg...

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Autores principales:	Do Young Park, Junyeop Lee, Jaeryung Kim, Kangsan Kim, Seonpyo Hong, Sangyeul Han, Yoshiaki Kubota, Hellmut G. Augustin, Lei Ding, Jin Woo Kim, Hail Kim, Yulong He, Ralf H. Adams, Gou Young Koh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c8b70a95fd88461dbf21669c1f36b7f1
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spelling	oai:doaj.org-article:c8b70a95fd88461dbf21669c1f36b7f12021-12-02T14:42:41ZPlastic roles of pericytes in the blood–retinal barrier10.1038/ncomms152962041-1723https://doaj.org/article/c8b70a95fd88461dbf21669c1f36b7f12017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15296https://doaj.org/toc/2041-1723Blood-retinal barrier (BRB) is composed of tightly connected endothelium and supporting pericytes and glia. Here, the authors show that pericytes are crucial for BRB buildup during retinal development and its maintenance in adult retinas in response to VEGF-A-induced endothelial sensitization by regulating the Tie2/FOXO1/Ang2 axis.Do Young ParkJunyeop LeeJaeryung KimKangsan KimSeonpyo HongSangyeul HanYoshiaki KubotaHellmut G. AugustinLei DingJin Woo KimHail KimYulong HeRalf H. AdamsGou Young KohNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Do Young Park Junyeop Lee Jaeryung Kim Kangsan Kim Seonpyo Hong Sangyeul Han Yoshiaki Kubota Hellmut G. Augustin Lei Ding Jin Woo Kim Hail Kim Yulong He Ralf H. Adams Gou Young Koh Plastic roles of pericytes in the blood–retinal barrier
description	Blood-retinal barrier (BRB) is composed of tightly connected endothelium and supporting pericytes and glia. Here, the authors show that pericytes are crucial for BRB buildup during retinal development and its maintenance in adult retinas in response to VEGF-A-induced endothelial sensitization by regulating the Tie2/FOXO1/Ang2 axis.
format	article
author	Do Young Park Junyeop Lee Jaeryung Kim Kangsan Kim Seonpyo Hong Sangyeul Han Yoshiaki Kubota Hellmut G. Augustin Lei Ding Jin Woo Kim Hail Kim Yulong He Ralf H. Adams Gou Young Koh
author_facet	Do Young Park Junyeop Lee Jaeryung Kim Kangsan Kim Seonpyo Hong Sangyeul Han Yoshiaki Kubota Hellmut G. Augustin Lei Ding Jin Woo Kim Hail Kim Yulong He Ralf H. Adams Gou Young Koh
author_sort	Do Young Park
title	Plastic roles of pericytes in the blood–retinal barrier
title_short	Plastic roles of pericytes in the blood–retinal barrier
title_full	Plastic roles of pericytes in the blood–retinal barrier
title_fullStr	Plastic roles of pericytes in the blood–retinal barrier
title_full_unstemmed	Plastic roles of pericytes in the blood–retinal barrier
title_sort	plastic roles of pericytes in the blood–retinal barrier
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c8b70a95fd88461dbf21669c1f36b7f1
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Plastic roles of pericytes in the blood–retinal barrier

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