Voltage gating of mechanosensitive PIEZO channels

PIEZO proteins form mechanosensitive ion channels. Here the authors present electrophysiological measurements that show that PIEZO channels are also modulated by voltage and can switch to a purely voltage gated mode, which is an evolutionary conserved property of this channel family.

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Detalles Bibliográficos
Autores principales: Mirko Moroni, M. Rocio Servin-Vences, Raluca Fleischer, Oscar Sánchez-Carranza, Gary R. Lewin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
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Acceso en línea:https://doaj.org/article/c8b799ea4464428ebbdd91025a26f225
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Descripción
Sumario:PIEZO proteins form mechanosensitive ion channels. Here the authors present electrophysiological measurements that show that PIEZO channels are also modulated by voltage and can switch to a purely voltage gated mode, which is an evolutionary conserved property of this channel family.