C16-ceramide is a natural regulatory ligand of p53 in cellular stress response

Ceramides are important participants of signal transduction, regulating fundamental cellular processes. Here authors show that C16-ceramide binds to the tumor suppressor p53, disrupts its interaction with MDM2 and facilitates p53 accumulation and activation of its downstream targets.

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Autores principales:	Baharan Fekry, Kristen A. Jeffries, Amin Esmaeilniakooshkghazi, Zdzislaw M. Szulc, Kevin J. Knagge, David R. Kirchner, David A. Horita, Sergey A. Krupenko, Natalia I. Krupenko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c8bb01b97ed94da88a335f1f599d147e
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spelling	oai:doaj.org-article:c8bb01b97ed94da88a335f1f599d147e2021-12-02T15:33:54ZC16-ceramide is a natural regulatory ligand of p53 in cellular stress response10.1038/s41467-018-06650-y2041-1723https://doaj.org/article/c8bb01b97ed94da88a335f1f599d147e2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06650-yhttps://doaj.org/toc/2041-1723Ceramides are important participants of signal transduction, regulating fundamental cellular processes. Here authors show that C16-ceramide binds to the tumor suppressor p53, disrupts its interaction with MDM2 and facilitates p53 accumulation and activation of its downstream targets.Baharan FekryKristen A. JeffriesAmin EsmaeilniakooshkghaziZdzislaw M. SzulcKevin J. KnaggeDavid R. KirchnerDavid A. HoritaSergey A. KrupenkoNatalia I. KrupenkoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Baharan Fekry Kristen A. Jeffries Amin Esmaeilniakooshkghazi Zdzislaw M. Szulc Kevin J. Knagge David R. Kirchner David A. Horita Sergey A. Krupenko Natalia I. Krupenko C16-ceramide is a natural regulatory ligand of p53 in cellular stress response
description	Ceramides are important participants of signal transduction, regulating fundamental cellular processes. Here authors show that C16-ceramide binds to the tumor suppressor p53, disrupts its interaction with MDM2 and facilitates p53 accumulation and activation of its downstream targets.
format	article
author	Baharan Fekry Kristen A. Jeffries Amin Esmaeilniakooshkghazi Zdzislaw M. Szulc Kevin J. Knagge David R. Kirchner David A. Horita Sergey A. Krupenko Natalia I. Krupenko
author_facet	Baharan Fekry Kristen A. Jeffries Amin Esmaeilniakooshkghazi Zdzislaw M. Szulc Kevin J. Knagge David R. Kirchner David A. Horita Sergey A. Krupenko Natalia I. Krupenko
author_sort	Baharan Fekry
title	C16-ceramide is a natural regulatory ligand of p53 in cellular stress response
title_short	C16-ceramide is a natural regulatory ligand of p53 in cellular stress response
title_full	C16-ceramide is a natural regulatory ligand of p53 in cellular stress response
title_fullStr	C16-ceramide is a natural regulatory ligand of p53 in cellular stress response
title_full_unstemmed	C16-ceramide is a natural regulatory ligand of p53 in cellular stress response
title_sort	c16-ceramide is a natural regulatory ligand of p53 in cellular stress response
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c8bb01b97ed94da88a335f1f599d147e
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C16-ceramide is a natural regulatory ligand of p53 in cellular stress response

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