Does FGF21 Mediate the Potential Decrease in Sweet Food Intake and Preference Following Bariatric Surgery?

The liver-derived hormone fibroblast growth factor 21 (FGF21) has recently been linked to preference for sweet-tasting food. We hypothesized, that surgery-induced changes in FGF21 could mediate the reduction in sweet food intake and preference following bariatric surgery. Forty participants (35 fema...

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Autores principales:	Mette S. Nielsen, Christian Ritz, Anne Chenchar, Wender L. P. Bredie, Matthew P. Gillum, Anders Sjödin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	fibroblast growth factor 21 roux-en-Y gastric bypass sleeve gastrectomy food preference taste preference sweet taste sensitivity Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/c8bda0d0cd114ca88b7cba18b905fa67
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spelling	oai:doaj.org-article:c8bda0d0cd114ca88b7cba18b905fa672021-11-25T18:34:34ZDoes FGF21 Mediate the Potential Decrease in Sweet Food Intake and Preference Following Bariatric Surgery?10.3390/nu131138402072-6643https://doaj.org/article/c8bda0d0cd114ca88b7cba18b905fa672021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3840https://doaj.org/toc/2072-6643The liver-derived hormone fibroblast growth factor 21 (FGF21) has recently been linked to preference for sweet-tasting food. We hypothesized, that surgery-induced changes in FGF21 could mediate the reduction in sweet food intake and preference following bariatric surgery. Forty participants (35 females) with severe obesity (BMI ≥ 35 kg/m<sup>2</sup>) scheduled for roux-en-y gastric bypass (<i>n</i> = 30) or sleeve gastrectomy (<i>n</i> = 10) were included. Pre- and postprandial responses of intact plasma FGF21 as well as intake of sweet-tasting food assessed at a buffet meal test, the hedonic evaluation of sweet taste assessed using an apple juice with added sucrose and visual analog scales, and sweet taste sensitivity were assessed before and 6 months after bariatric surgery. In a cross-sectional analysis pre-surgery, pre- and postprandial intact FGF21 levels were negatively associated with the hedonic evaluation of a high-sucrose juice sample (<i>p</i> = 0.03 and <i>p</i> = 0.02). However, no changes in pre- (<i>p</i> = 0.24) or postprandial intact FGF21 levels were found 6 months after surgery (<i>p</i> = 0.11), and individual pre- to postoperative changes in pre- and postprandial intact FGF21 levels were not found to be associated with changes in intake of sweet foods, the hedonic evaluation of sweet taste or sweet taste sensitivity (all <i>p</i> ≥ 0.10). In conclusion, we were not able to show an effect of bariatric surgery on circulating FGF21, and individual postoperative changes in FGF21 were not found to mediate an effect of surgery on sweet food intake and preference.Mette S. NielsenChristian RitzAnne ChencharWender L. P. BredieMatthew P. GillumAnders SjödinMDPI AGarticlefibroblast growth factor 21roux-en-Y gastric bypasssleeve gastrectomyfood preferencetaste preferencesweet taste sensitivityNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3840, p 3840 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fibroblast growth factor 21 roux-en-Y gastric bypass sleeve gastrectomy food preference taste preference sweet taste sensitivity Nutrition. Foods and food supply TX341-641
spellingShingle	fibroblast growth factor 21 roux-en-Y gastric bypass sleeve gastrectomy food preference taste preference sweet taste sensitivity Nutrition. Foods and food supply TX341-641 Mette S. Nielsen Christian Ritz Anne Chenchar Wender L. P. Bredie Matthew P. Gillum Anders Sjödin Does FGF21 Mediate the Potential Decrease in Sweet Food Intake and Preference Following Bariatric Surgery?
description	The liver-derived hormone fibroblast growth factor 21 (FGF21) has recently been linked to preference for sweet-tasting food. We hypothesized, that surgery-induced changes in FGF21 could mediate the reduction in sweet food intake and preference following bariatric surgery. Forty participants (35 females) with severe obesity (BMI ≥ 35 kg/m<sup>2</sup>) scheduled for roux-en-y gastric bypass (<i>n</i> = 30) or sleeve gastrectomy (<i>n</i> = 10) were included. Pre- and postprandial responses of intact plasma FGF21 as well as intake of sweet-tasting food assessed at a buffet meal test, the hedonic evaluation of sweet taste assessed using an apple juice with added sucrose and visual analog scales, and sweet taste sensitivity were assessed before and 6 months after bariatric surgery. In a cross-sectional analysis pre-surgery, pre- and postprandial intact FGF21 levels were negatively associated with the hedonic evaluation of a high-sucrose juice sample (<i>p</i> = 0.03 and <i>p</i> = 0.02). However, no changes in pre- (<i>p</i> = 0.24) or postprandial intact FGF21 levels were found 6 months after surgery (<i>p</i> = 0.11), and individual pre- to postoperative changes in pre- and postprandial intact FGF21 levels were not found to be associated with changes in intake of sweet foods, the hedonic evaluation of sweet taste or sweet taste sensitivity (all <i>p</i> ≥ 0.10). In conclusion, we were not able to show an effect of bariatric surgery on circulating FGF21, and individual postoperative changes in FGF21 were not found to mediate an effect of surgery on sweet food intake and preference.
format	article
author	Mette S. Nielsen Christian Ritz Anne Chenchar Wender L. P. Bredie Matthew P. Gillum Anders Sjödin
author_facet	Mette S. Nielsen Christian Ritz Anne Chenchar Wender L. P. Bredie Matthew P. Gillum Anders Sjödin
author_sort	Mette S. Nielsen
title	Does FGF21 Mediate the Potential Decrease in Sweet Food Intake and Preference Following Bariatric Surgery?
title_short	Does FGF21 Mediate the Potential Decrease in Sweet Food Intake and Preference Following Bariatric Surgery?
title_full	Does FGF21 Mediate the Potential Decrease in Sweet Food Intake and Preference Following Bariatric Surgery?
title_fullStr	Does FGF21 Mediate the Potential Decrease in Sweet Food Intake and Preference Following Bariatric Surgery?
title_full_unstemmed	Does FGF21 Mediate the Potential Decrease in Sweet Food Intake and Preference Following Bariatric Surgery?
title_sort	does fgf21 mediate the potential decrease in sweet food intake and preference following bariatric surgery?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c8bda0d0cd114ca88b7cba18b905fa67
work_keys_str_mv	AT mettesnielsen doesfgf21mediatethepotentialdecreaseinsweetfoodintakeandpreferencefollowingbariatricsurgery AT christianritz doesfgf21mediatethepotentialdecreaseinsweetfoodintakeandpreferencefollowingbariatricsurgery AT annechenchar doesfgf21mediatethepotentialdecreaseinsweetfoodintakeandpreferencefollowingbariatricsurgery AT wenderlpbredie doesfgf21mediatethepotentialdecreaseinsweetfoodintakeandpreferencefollowingbariatricsurgery AT matthewpgillum doesfgf21mediatethepotentialdecreaseinsweetfoodintakeandpreferencefollowingbariatricsurgery AT anderssjodin doesfgf21mediatethepotentialdecreaseinsweetfoodintakeandpreferencefollowingbariatricsurgery
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Does FGF21 Mediate the Potential Decrease in Sweet Food Intake and Preference Following Bariatric Surgery?

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