SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade

SMARCA4 is commonly inactivated in lung and ovarian cancers. Here the authors show that SMARCA4-deficient tumours have significantly reduced levels of the histone demethylases KDM6s and a strong dependency on these demethylases for tumour growth, so that they are vulnerable to KDM6s inhibition.

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Autores principales:	Octavio A. Romero, Andrea Vilarrubi, Juan J. Alburquerque-Bejar, Antonio Gomez, Alvaro Andrades, Deborah Trastulli, Eva Pros, Fernando Setien, Sara Verdura, Lourdes Farré, Juan F. Martín-Tejera, Paula Llabata, Ana Oaknin, Maria Saigi, Josep M. Piulats, Xavier Matias-Guiu, Pedro P. Medina, August Vidal, Alberto Villanueva, Montse Sanchez-Cespedes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c8c005713fd44b6bbb0151fbe7d89bec
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spelling	oai:doaj.org-article:c8c005713fd44b6bbb0151fbe7d89bec2021-12-02T18:36:59ZSMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade10.1038/s41467-021-24618-32041-1723https://doaj.org/article/c8c005713fd44b6bbb0151fbe7d89bec2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24618-3https://doaj.org/toc/2041-1723SMARCA4 is commonly inactivated in lung and ovarian cancers. Here the authors show that SMARCA4-deficient tumours have significantly reduced levels of the histone demethylases KDM6s and a strong dependency on these demethylases for tumour growth, so that they are vulnerable to KDM6s inhibition.Octavio A. RomeroAndrea VilarrubiJuan J. Alburquerque-BejarAntonio GomezAlvaro AndradesDeborah TrastulliEva ProsFernando SetienSara VerduraLourdes FarréJuan F. Martín-TejeraPaula LlabataAna OakninMaria SaigiJosep M. PiulatsXavier Matias-GuiuPedro P. MedinaAugust VidalAlberto VillanuevaMontse Sanchez-CespedesNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Octavio A. Romero Andrea Vilarrubi Juan J. Alburquerque-Bejar Antonio Gomez Alvaro Andrades Deborah Trastulli Eva Pros Fernando Setien Sara Verdura Lourdes Farré Juan F. Martín-Tejera Paula Llabata Ana Oaknin Maria Saigi Josep M. Piulats Xavier Matias-Guiu Pedro P. Medina August Vidal Alberto Villanueva Montse Sanchez-Cespedes SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade
description	SMARCA4 is commonly inactivated in lung and ovarian cancers. Here the authors show that SMARCA4-deficient tumours have significantly reduced levels of the histone demethylases KDM6s and a strong dependency on these demethylases for tumour growth, so that they are vulnerable to KDM6s inhibition.
format	article
author	Octavio A. Romero Andrea Vilarrubi Juan J. Alburquerque-Bejar Antonio Gomez Alvaro Andrades Deborah Trastulli Eva Pros Fernando Setien Sara Verdura Lourdes Farré Juan F. Martín-Tejera Paula Llabata Ana Oaknin Maria Saigi Josep M. Piulats Xavier Matias-Guiu Pedro P. Medina August Vidal Alberto Villanueva Montse Sanchez-Cespedes
author_facet	Octavio A. Romero Andrea Vilarrubi Juan J. Alburquerque-Bejar Antonio Gomez Alvaro Andrades Deborah Trastulli Eva Pros Fernando Setien Sara Verdura Lourdes Farré Juan F. Martín-Tejera Paula Llabata Ana Oaknin Maria Saigi Josep M. Piulats Xavier Matias-Guiu Pedro P. Medina August Vidal Alberto Villanueva Montse Sanchez-Cespedes
author_sort	Octavio A. Romero
title	SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade
title_short	SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade
title_full	SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade
title_fullStr	SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade
title_full_unstemmed	SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade
title_sort	smarca4 deficient tumours are vulnerable to kdm6a/utx and kdm6b/jmjd3 blockade
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c8c005713fd44b6bbb0151fbe7d89bec
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SMARCA4 deficient tumours are vulnerable to KDM6A/UTX and KDM6B/JMJD3 blockade

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