Volatile organic breath components and exercise induced bronchoconstriction in asthmatic children

Abstract Introduction Asthma is one of the most common chronic diseases in childhood and is generally characterized by exercise induced bronchoconstriction (EIB). Assessing EIB is time consuming and expensive as it requires a fully equipped pulmonary function laboratory. Analysis of volatile organic...

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Autores principales:	M. R. van der Kamp, J. M. M. Driessen, M. P. van der Schee, B. J. Thio, F. H. C. de Jongh
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Asthma Children Breath condensate Exercise induced bronchoconstriction Salbutamol Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/c8c164b39db8439b8087091f02990b27
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spelling	oai:doaj.org-article:c8c164b39db8439b8087091f02990b272021-11-28T12:36:18ZVolatile organic breath components and exercise induced bronchoconstriction in asthmatic children10.1186/s13223-021-00622-61710-1492https://doaj.org/article/c8c164b39db8439b8087091f02990b272021-11-01T00:00:00Zhttps://doi.org/10.1186/s13223-021-00622-6https://doaj.org/toc/1710-1492Abstract Introduction Asthma is one of the most common chronic diseases in childhood and is generally characterized by exercise induced bronchoconstriction (EIB). Assessing EIB is time consuming and expensive as it requires a fully equipped pulmonary function laboratory. Analysis of volatile organic compounds (VOCs) in breath is a novel technique for examining biomarkers which may associate with asthma features. The aim of this pilot study was to identify potential markers in the relationship between EIB and VOCs. Methods Children between four and 14 years old were asked to provide a breath sample prior to undergoing an exercise challenge test to assess for EIB. Results Breath samples were collected and analyzed in 46 asthmatic children, 21 with EIB and 25 without EIB (NO-EIB). Molecular features (MFs) were not significantly different between EIB and NO-EIB controls. 29 of the 46 children were corticosteroid naïve, 10 with EIB and 13 without. In the corticosteroid naïve group EIB was associated with increased MF23 and MF14 in the lower breath sample (p-value < 0.05). Conclusion This pilot study shows that EIB was related to an increased MF14 and MF23 in corticosteroid naïve children. The tentative identities of these compounds are octanal and dodecane/tetradecane respectively. These candidate biomarkers have a potential to enable non-invasive diagnosis of EIB in steroid-naïve children. Trial registration This study is registered in the Netherlands trial register (trial no. NL6087) at 14 February 2017.M. R. van der KampJ. M. M. DriessenM. P. van der ScheeB. J. ThioF. H. C. de JonghBMCarticleAsthmaChildrenBreath condensateExercise induced bronchoconstrictionSalbutamolImmunologic diseases. AllergyRC581-607ENAllergy, Asthma & Clinical Immunology, Vol 17, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Asthma Children Breath condensate Exercise induced bronchoconstriction Salbutamol Immunologic diseases. Allergy RC581-607
spellingShingle	Asthma Children Breath condensate Exercise induced bronchoconstriction Salbutamol Immunologic diseases. Allergy RC581-607 M. R. van der Kamp J. M. M. Driessen M. P. van der Schee B. J. Thio F. H. C. de Jongh Volatile organic breath components and exercise induced bronchoconstriction in asthmatic children
description	Abstract Introduction Asthma is one of the most common chronic diseases in childhood and is generally characterized by exercise induced bronchoconstriction (EIB). Assessing EIB is time consuming and expensive as it requires a fully equipped pulmonary function laboratory. Analysis of volatile organic compounds (VOCs) in breath is a novel technique for examining biomarkers which may associate with asthma features. The aim of this pilot study was to identify potential markers in the relationship between EIB and VOCs. Methods Children between four and 14 years old were asked to provide a breath sample prior to undergoing an exercise challenge test to assess for EIB. Results Breath samples were collected and analyzed in 46 asthmatic children, 21 with EIB and 25 without EIB (NO-EIB). Molecular features (MFs) were not significantly different between EIB and NO-EIB controls. 29 of the 46 children were corticosteroid naïve, 10 with EIB and 13 without. In the corticosteroid naïve group EIB was associated with increased MF23 and MF14 in the lower breath sample (p-value < 0.05). Conclusion This pilot study shows that EIB was related to an increased MF14 and MF23 in corticosteroid naïve children. The tentative identities of these compounds are octanal and dodecane/tetradecane respectively. These candidate biomarkers have a potential to enable non-invasive diagnosis of EIB in steroid-naïve children. Trial registration This study is registered in the Netherlands trial register (trial no. NL6087) at 14 February 2017.
format	article
author	M. R. van der Kamp J. M. M. Driessen M. P. van der Schee B. J. Thio F. H. C. de Jongh
author_facet	M. R. van der Kamp J. M. M. Driessen M. P. van der Schee B. J. Thio F. H. C. de Jongh
author_sort	M. R. van der Kamp
title	Volatile organic breath components and exercise induced bronchoconstriction in asthmatic children
title_short	Volatile organic breath components and exercise induced bronchoconstriction in asthmatic children
title_full	Volatile organic breath components and exercise induced bronchoconstriction in asthmatic children
title_fullStr	Volatile organic breath components and exercise induced bronchoconstriction in asthmatic children
title_full_unstemmed	Volatile organic breath components and exercise induced bronchoconstriction in asthmatic children
title_sort	volatile organic breath components and exercise induced bronchoconstriction in asthmatic children
publisher	BMC
publishDate	2021
url	https://doaj.org/article/c8c164b39db8439b8087091f02990b27
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Volatile organic breath components and exercise induced bronchoconstriction in asthmatic children

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