The splicing factor RBM25 controls MYC activity in acute myeloid leukemia

Splicing factors are often mutated in hematological malignancies. Here, the authors perform an in vivo shRNA screen in a CEBPA mutant AML mouse model and identify that RBM25 controls the splicing of pre-mRNAs encoding BCL-X and BIN1 to exert its tumour suppressor activities in AML.

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Autores principales:	Ying Ge, Mikkel Bruhn Schuster, Sachin Pundhir, Nicolas Rapin, Frederik Otzen Bagger, Nikos Sidiropoulos, Nadia Hashem, Bo Torben Porse
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c8c6d484a5294d499e04f34dc0adabb8
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spelling	oai:doaj.org-article:c8c6d484a5294d499e04f34dc0adabb82021-12-02T17:32:25ZThe splicing factor RBM25 controls MYC activity in acute myeloid leukemia10.1038/s41467-018-08076-y2041-1723https://doaj.org/article/c8c6d484a5294d499e04f34dc0adabb82019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08076-yhttps://doaj.org/toc/2041-1723Splicing factors are often mutated in hematological malignancies. Here, the authors perform an in vivo shRNA screen in a CEBPA mutant AML mouse model and identify that RBM25 controls the splicing of pre-mRNAs encoding BCL-X and BIN1 to exert its tumour suppressor activities in AML.Ying GeMikkel Bruhn SchusterSachin PundhirNicolas RapinFrederik Otzen BaggerNikos SidiropoulosNadia HashemBo Torben PorseNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ying Ge Mikkel Bruhn Schuster Sachin Pundhir Nicolas Rapin Frederik Otzen Bagger Nikos Sidiropoulos Nadia Hashem Bo Torben Porse The splicing factor RBM25 controls MYC activity in acute myeloid leukemia
description	Splicing factors are often mutated in hematological malignancies. Here, the authors perform an in vivo shRNA screen in a CEBPA mutant AML mouse model and identify that RBM25 controls the splicing of pre-mRNAs encoding BCL-X and BIN1 to exert its tumour suppressor activities in AML.
format	article
author	Ying Ge Mikkel Bruhn Schuster Sachin Pundhir Nicolas Rapin Frederik Otzen Bagger Nikos Sidiropoulos Nadia Hashem Bo Torben Porse
author_facet	Ying Ge Mikkel Bruhn Schuster Sachin Pundhir Nicolas Rapin Frederik Otzen Bagger Nikos Sidiropoulos Nadia Hashem Bo Torben Porse
author_sort	Ying Ge
title	The splicing factor RBM25 controls MYC activity in acute myeloid leukemia
title_short	The splicing factor RBM25 controls MYC activity in acute myeloid leukemia
title_full	The splicing factor RBM25 controls MYC activity in acute myeloid leukemia
title_fullStr	The splicing factor RBM25 controls MYC activity in acute myeloid leukemia
title_full_unstemmed	The splicing factor RBM25 controls MYC activity in acute myeloid leukemia
title_sort	splicing factor rbm25 controls myc activity in acute myeloid leukemia
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c8c6d484a5294d499e04f34dc0adabb8
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The splicing factor RBM25 controls MYC activity in acute myeloid leukemia

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