A descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in India

Abstract The World Health Organization (WHO) has articulated a priority pathogens list (PPL) to provide strategic direction to research and develop new antimicrobials. Antimicrobial resistance (AMR) patterns of WHO PPL in a tertiary health care facility in Southern India were explored to understand...

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Autores principales: Vijayalaxmi V. Mogasale, Prakash Saldanha, Vidya Pai, P. D. Rekha, Vittal Mogasale
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/c8c75d60973f49db9bce145944e9e99a
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spelling oai:doaj.org-article:c8c75d60973f49db9bce145944e9e99a2021-12-02T13:35:04ZA descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in India10.1038/s41598-021-84293-82045-2322https://doaj.org/article/c8c75d60973f49db9bce145944e9e99a2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84293-8https://doaj.org/toc/2045-2322Abstract The World Health Organization (WHO) has articulated a priority pathogens list (PPL) to provide strategic direction to research and develop new antimicrobials. Antimicrobial resistance (AMR) patterns of WHO PPL in a tertiary health care facility in Southern India were explored to understand the local priority pathogens. Culture reports of laboratory specimens collected between 1st January 2014 and 31st October 2019 from paediatric patients were extracted. The antimicrobial susceptibility patterns for selected antimicrobials on the WHO PPL were analysed and reported. Of 12,256 culture specimens screened, 2335 (19%) showed culture positivity, of which 1556 (66.6%) were organisms from the WHO-PPL. E. coli was the most common organism isolated (37%), followed by Staphylococcus aureus (16%). Total of 72% of E. coli were extended-spectrum beta-lactamases (ESBL) producers, 55% of Enterobacteriaceae were resistant to 3rd generation cephalosporins due to ESBL, and 53% of Staph. aureus were Methicillin-resistant. The analysis showed AMR trends and prevalence patterns in the study setting and the WHO-PPL document are not fully comparable. This kind of local priority difference needs to be recognised in local policies and practices.Vijayalaxmi V. MogasalePrakash SaldanhaVidya PaiP. D. RekhaVittal MogasaleNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Vijayalaxmi V. Mogasale
Prakash Saldanha
Vidya Pai
P. D. Rekha
Vittal Mogasale
A descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in India
description Abstract The World Health Organization (WHO) has articulated a priority pathogens list (PPL) to provide strategic direction to research and develop new antimicrobials. Antimicrobial resistance (AMR) patterns of WHO PPL in a tertiary health care facility in Southern India were explored to understand the local priority pathogens. Culture reports of laboratory specimens collected between 1st January 2014 and 31st October 2019 from paediatric patients were extracted. The antimicrobial susceptibility patterns for selected antimicrobials on the WHO PPL were analysed and reported. Of 12,256 culture specimens screened, 2335 (19%) showed culture positivity, of which 1556 (66.6%) were organisms from the WHO-PPL. E. coli was the most common organism isolated (37%), followed by Staphylococcus aureus (16%). Total of 72% of E. coli were extended-spectrum beta-lactamases (ESBL) producers, 55% of Enterobacteriaceae were resistant to 3rd generation cephalosporins due to ESBL, and 53% of Staph. aureus were Methicillin-resistant. The analysis showed AMR trends and prevalence patterns in the study setting and the WHO-PPL document are not fully comparable. This kind of local priority difference needs to be recognised in local policies and practices.
format article
author Vijayalaxmi V. Mogasale
Prakash Saldanha
Vidya Pai
P. D. Rekha
Vittal Mogasale
author_facet Vijayalaxmi V. Mogasale
Prakash Saldanha
Vidya Pai
P. D. Rekha
Vittal Mogasale
author_sort Vijayalaxmi V. Mogasale
title A descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in India
title_short A descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in India
title_full A descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in India
title_fullStr A descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in India
title_full_unstemmed A descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in India
title_sort descriptive analysis of antimicrobial resistance patterns of who priority pathogens isolated in children from a tertiary care hospital in india
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/c8c75d60973f49db9bce145944e9e99a
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