A descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in India
Abstract The World Health Organization (WHO) has articulated a priority pathogens list (PPL) to provide strategic direction to research and develop new antimicrobials. Antimicrobial resistance (AMR) patterns of WHO PPL in a tertiary health care facility in Southern India were explored to understand...
Guardado en:
Autores principales: | , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/c8c75d60973f49db9bce145944e9e99a |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:c8c75d60973f49db9bce145944e9e99a |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:c8c75d60973f49db9bce145944e9e99a2021-12-02T13:35:04ZA descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in India10.1038/s41598-021-84293-82045-2322https://doaj.org/article/c8c75d60973f49db9bce145944e9e99a2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84293-8https://doaj.org/toc/2045-2322Abstract The World Health Organization (WHO) has articulated a priority pathogens list (PPL) to provide strategic direction to research and develop new antimicrobials. Antimicrobial resistance (AMR) patterns of WHO PPL in a tertiary health care facility in Southern India were explored to understand the local priority pathogens. Culture reports of laboratory specimens collected between 1st January 2014 and 31st October 2019 from paediatric patients were extracted. The antimicrobial susceptibility patterns for selected antimicrobials on the WHO PPL were analysed and reported. Of 12,256 culture specimens screened, 2335 (19%) showed culture positivity, of which 1556 (66.6%) were organisms from the WHO-PPL. E. coli was the most common organism isolated (37%), followed by Staphylococcus aureus (16%). Total of 72% of E. coli were extended-spectrum beta-lactamases (ESBL) producers, 55% of Enterobacteriaceae were resistant to 3rd generation cephalosporins due to ESBL, and 53% of Staph. aureus were Methicillin-resistant. The analysis showed AMR trends and prevalence patterns in the study setting and the WHO-PPL document are not fully comparable. This kind of local priority difference needs to be recognised in local policies and practices.Vijayalaxmi V. MogasalePrakash SaldanhaVidya PaiP. D. RekhaVittal MogasaleNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q Vijayalaxmi V. Mogasale Prakash Saldanha Vidya Pai P. D. Rekha Vittal Mogasale A descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in India |
description |
Abstract The World Health Organization (WHO) has articulated a priority pathogens list (PPL) to provide strategic direction to research and develop new antimicrobials. Antimicrobial resistance (AMR) patterns of WHO PPL in a tertiary health care facility in Southern India were explored to understand the local priority pathogens. Culture reports of laboratory specimens collected between 1st January 2014 and 31st October 2019 from paediatric patients were extracted. The antimicrobial susceptibility patterns for selected antimicrobials on the WHO PPL were analysed and reported. Of 12,256 culture specimens screened, 2335 (19%) showed culture positivity, of which 1556 (66.6%) were organisms from the WHO-PPL. E. coli was the most common organism isolated (37%), followed by Staphylococcus aureus (16%). Total of 72% of E. coli were extended-spectrum beta-lactamases (ESBL) producers, 55% of Enterobacteriaceae were resistant to 3rd generation cephalosporins due to ESBL, and 53% of Staph. aureus were Methicillin-resistant. The analysis showed AMR trends and prevalence patterns in the study setting and the WHO-PPL document are not fully comparable. This kind of local priority difference needs to be recognised in local policies and practices. |
format |
article |
author |
Vijayalaxmi V. Mogasale Prakash Saldanha Vidya Pai P. D. Rekha Vittal Mogasale |
author_facet |
Vijayalaxmi V. Mogasale Prakash Saldanha Vidya Pai P. D. Rekha Vittal Mogasale |
author_sort |
Vijayalaxmi V. Mogasale |
title |
A descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in India |
title_short |
A descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in India |
title_full |
A descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in India |
title_fullStr |
A descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in India |
title_full_unstemmed |
A descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in India |
title_sort |
descriptive analysis of antimicrobial resistance patterns of who priority pathogens isolated in children from a tertiary care hospital in india |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/c8c75d60973f49db9bce145944e9e99a |
work_keys_str_mv |
AT vijayalaxmivmogasale adescriptiveanalysisofantimicrobialresistancepatternsofwhoprioritypathogensisolatedinchildrenfromatertiarycarehospitalinindia AT prakashsaldanha adescriptiveanalysisofantimicrobialresistancepatternsofwhoprioritypathogensisolatedinchildrenfromatertiarycarehospitalinindia AT vidyapai adescriptiveanalysisofantimicrobialresistancepatternsofwhoprioritypathogensisolatedinchildrenfromatertiarycarehospitalinindia AT pdrekha adescriptiveanalysisofantimicrobialresistancepatternsofwhoprioritypathogensisolatedinchildrenfromatertiarycarehospitalinindia AT vittalmogasale adescriptiveanalysisofantimicrobialresistancepatternsofwhoprioritypathogensisolatedinchildrenfromatertiarycarehospitalinindia AT vijayalaxmivmogasale descriptiveanalysisofantimicrobialresistancepatternsofwhoprioritypathogensisolatedinchildrenfromatertiarycarehospitalinindia AT prakashsaldanha descriptiveanalysisofantimicrobialresistancepatternsofwhoprioritypathogensisolatedinchildrenfromatertiarycarehospitalinindia AT vidyapai descriptiveanalysisofantimicrobialresistancepatternsofwhoprioritypathogensisolatedinchildrenfromatertiarycarehospitalinindia AT pdrekha descriptiveanalysisofantimicrobialresistancepatternsofwhoprioritypathogensisolatedinchildrenfromatertiarycarehospitalinindia AT vittalmogasale descriptiveanalysisofantimicrobialresistancepatternsofwhoprioritypathogensisolatedinchildrenfromatertiarycarehospitalinindia |
_version_ |
1718392699987427328 |