Flavonoids and Omega3 Prevent Muscle and Cardiac Damage in Duchenne Muscular Dystrophy Animal Model

Nutraceutical products possess various anti-inflammatory, antiarrhythmic, cardiotonic, and antioxidant pharmacological activities that could be useful in preventing oxidative damage, mainly induced by reactive oxygen species. Previously published data showed that a mixture of polyphenols and polyuns...

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Autores principales:	Luana Tripodi, Davide Molinaro, Andrea Farini, Gendenver Cadiao, Chiara Villa, Yvan Torrente
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	muscle homeostasis muscle regeneration satellite cells inflammatory response Duchenne muscular dystrophy food supplement Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c8ca0d2384d84e06b5837e0ef6b8fa76
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spelling	oai:doaj.org-article:c8ca0d2384d84e06b5837e0ef6b8fa762021-11-25T17:08:53ZFlavonoids and Omega3 Prevent Muscle and Cardiac Damage in Duchenne Muscular Dystrophy Animal Model10.3390/cells101129172073-4409https://doaj.org/article/c8ca0d2384d84e06b5837e0ef6b8fa762021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/2917https://doaj.org/toc/2073-4409Nutraceutical products possess various anti-inflammatory, antiarrhythmic, cardiotonic, and antioxidant pharmacological activities that could be useful in preventing oxidative damage, mainly induced by reactive oxygen species. Previously published data showed that a mixture of polyphenols and polyunsaturated fatty acids, mediate an antioxidative response in mdx mice, Duchenne muscular dystrophy animal model. Dystrophic muscles are characterized by low regenerative capacity, fibrosis, fiber necrosis, inflammatory process, altered autophagic flux and inadequate anti-oxidant response. FLAVOmega β is a mixture of flavonoids and docosahexaenoic acid. In this study, we evaluated the role of these supplements in the amelioration of the pathological phenotype in dystrophic mice through in vitro and in vivo assays. FLAVOmega β reduced inflammation and fibrosis, dampened reactive oxygen species production, and induced an oxidative metabolic switch of myofibers, with consequent increase of mitochondrial activity, vascularization, and fatigue resistance. Therefore, we propose FLAVOmega β as food supplement suitable for preventing muscle weakness, delaying inflammatory milieu, and sustaining physical health in patients affected from DMD.Luana TripodiDavide MolinaroAndrea FariniGendenver CadiaoChiara VillaYvan TorrenteMDPI AGarticlemuscle homeostasismuscle regenerationsatellite cellsinflammatory responseDuchenne muscular dystrophyfood supplementBiology (General)QH301-705.5ENCells, Vol 10, Iss 2917, p 2917 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	muscle homeostasis muscle regeneration satellite cells inflammatory response Duchenne muscular dystrophy food supplement Biology (General) QH301-705.5
spellingShingle	muscle homeostasis muscle regeneration satellite cells inflammatory response Duchenne muscular dystrophy food supplement Biology (General) QH301-705.5 Luana Tripodi Davide Molinaro Andrea Farini Gendenver Cadiao Chiara Villa Yvan Torrente Flavonoids and Omega3 Prevent Muscle and Cardiac Damage in Duchenne Muscular Dystrophy Animal Model
description	Nutraceutical products possess various anti-inflammatory, antiarrhythmic, cardiotonic, and antioxidant pharmacological activities that could be useful in preventing oxidative damage, mainly induced by reactive oxygen species. Previously published data showed that a mixture of polyphenols and polyunsaturated fatty acids, mediate an antioxidative response in mdx mice, Duchenne muscular dystrophy animal model. Dystrophic muscles are characterized by low regenerative capacity, fibrosis, fiber necrosis, inflammatory process, altered autophagic flux and inadequate anti-oxidant response. FLAVOmega β is a mixture of flavonoids and docosahexaenoic acid. In this study, we evaluated the role of these supplements in the amelioration of the pathological phenotype in dystrophic mice through in vitro and in vivo assays. FLAVOmega β reduced inflammation and fibrosis, dampened reactive oxygen species production, and induced an oxidative metabolic switch of myofibers, with consequent increase of mitochondrial activity, vascularization, and fatigue resistance. Therefore, we propose FLAVOmega β as food supplement suitable for preventing muscle weakness, delaying inflammatory milieu, and sustaining physical health in patients affected from DMD.
format	article
author	Luana Tripodi Davide Molinaro Andrea Farini Gendenver Cadiao Chiara Villa Yvan Torrente
author_facet	Luana Tripodi Davide Molinaro Andrea Farini Gendenver Cadiao Chiara Villa Yvan Torrente
author_sort	Luana Tripodi
title	Flavonoids and Omega3 Prevent Muscle and Cardiac Damage in Duchenne Muscular Dystrophy Animal Model
title_short	Flavonoids and Omega3 Prevent Muscle and Cardiac Damage in Duchenne Muscular Dystrophy Animal Model
title_full	Flavonoids and Omega3 Prevent Muscle and Cardiac Damage in Duchenne Muscular Dystrophy Animal Model
title_fullStr	Flavonoids and Omega3 Prevent Muscle and Cardiac Damage in Duchenne Muscular Dystrophy Animal Model
title_full_unstemmed	Flavonoids and Omega3 Prevent Muscle and Cardiac Damage in Duchenne Muscular Dystrophy Animal Model
title_sort	flavonoids and omega3 prevent muscle and cardiac damage in duchenne muscular dystrophy animal model
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c8ca0d2384d84e06b5837e0ef6b8fa76
work_keys_str_mv	AT luanatripodi flavonoidsandomega3preventmuscleandcardiacdamageinduchennemusculardystrophyanimalmodel AT davidemolinaro flavonoidsandomega3preventmuscleandcardiacdamageinduchennemusculardystrophyanimalmodel AT andreafarini flavonoidsandomega3preventmuscleandcardiacdamageinduchennemusculardystrophyanimalmodel AT gendenvercadiao flavonoidsandomega3preventmuscleandcardiacdamageinduchennemusculardystrophyanimalmodel AT chiaravilla flavonoidsandomega3preventmuscleandcardiacdamageinduchennemusculardystrophyanimalmodel AT yvantorrente flavonoidsandomega3preventmuscleandcardiacdamageinduchennemusculardystrophyanimalmodel
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Flavonoids and Omega3 Prevent Muscle and Cardiac Damage in Duchenne Muscular Dystrophy Animal Model

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