Corneal biomechanical parameters in keratoconus eyes with abnormal elevation on the back corneal surface only versus both back and front surfaces

Abstract Corneal biomechanical parameters were compared in 100 keratoconus eyes with abnormal elevation on the back corneal surface only (group 1), versus both the back and front surfaces (group 2). Scheimpflug tomography with Pentacam HR, corneal biomechanical assessments using Corvis ST and Ocular...

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Autores principales:	Mohammad-Reza Sedaghat, Hamed Momeni-Moghaddam, Cynthia J. Roberts, Nasim Maddah, Renato Ambrósio, Seyed Rafi Hosseini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c8cd64b034234d1fa373047c0bce6c71
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spelling	oai:doaj.org-article:c8cd64b034234d1fa373047c0bce6c712021-12-02T14:59:36ZCorneal biomechanical parameters in keratoconus eyes with abnormal elevation on the back corneal surface only versus both back and front surfaces10.1038/s41598-021-91263-72045-2322https://doaj.org/article/c8cd64b034234d1fa373047c0bce6c712021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91263-7https://doaj.org/toc/2045-2322Abstract Corneal biomechanical parameters were compared in 100 keratoconus eyes with abnormal elevation on the back corneal surface only (group 1), versus both the back and front surfaces (group 2). Scheimpflug tomography with Pentacam HR, corneal biomechanical assessments using Corvis ST and Ocular Response Analyzer (ORA) and corneal epithelium thickness maps using anterior segment optical coherence tomography were assessed. There were no significant differences in the IOP measured using Corvis ST and ORA, age or sex between the two groups. Statistically significant differences were found in all corneal shape parameters and all new parameters of Corvis ST: corneal stiffness parameter at first applanation (SP-A1), integrated inverse radius (IR) and deformation amplitude ratio (DAR)) between groups (p < 0.001). The classic parameters of ORA including corneal hysteresis (CH) and corneal resistance factor (CRF) were about 1.00 mmHg higher in group 1 (p < 0.001). In conclusion, keratoconus eyes with abnormal elevation limited to the back corneal surface have lower grade, stiffer corneal biomechanical parameters and less asymmetric shape. This is consistent with progressive biomechanical weakening from the first detectable back surface elevation to manifestation on the front surface as the severity overwhelms the ability of the epithelium to compensate.Mohammad-Reza SedaghatHamed Momeni-MoghaddamCynthia J. RobertsNasim MaddahRenato AmbrósioSeyed Rafi HosseiniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mohammad-Reza Sedaghat Hamed Momeni-Moghaddam Cynthia J. Roberts Nasim Maddah Renato Ambrósio Seyed Rafi Hosseini Corneal biomechanical parameters in keratoconus eyes with abnormal elevation on the back corneal surface only versus both back and front surfaces
description	Abstract Corneal biomechanical parameters were compared in 100 keratoconus eyes with abnormal elevation on the back corneal surface only (group 1), versus both the back and front surfaces (group 2). Scheimpflug tomography with Pentacam HR, corneal biomechanical assessments using Corvis ST and Ocular Response Analyzer (ORA) and corneal epithelium thickness maps using anterior segment optical coherence tomography were assessed. There were no significant differences in the IOP measured using Corvis ST and ORA, age or sex between the two groups. Statistically significant differences were found in all corneal shape parameters and all new parameters of Corvis ST: corneal stiffness parameter at first applanation (SP-A1), integrated inverse radius (IR) and deformation amplitude ratio (DAR)) between groups (p < 0.001). The classic parameters of ORA including corneal hysteresis (CH) and corneal resistance factor (CRF) were about 1.00 mmHg higher in group 1 (p < 0.001). In conclusion, keratoconus eyes with abnormal elevation limited to the back corneal surface have lower grade, stiffer corneal biomechanical parameters and less asymmetric shape. This is consistent with progressive biomechanical weakening from the first detectable back surface elevation to manifestation on the front surface as the severity overwhelms the ability of the epithelium to compensate.
format	article
author	Mohammad-Reza Sedaghat Hamed Momeni-Moghaddam Cynthia J. Roberts Nasim Maddah Renato Ambrósio Seyed Rafi Hosseini
author_facet	Mohammad-Reza Sedaghat Hamed Momeni-Moghaddam Cynthia J. Roberts Nasim Maddah Renato Ambrósio Seyed Rafi Hosseini
author_sort	Mohammad-Reza Sedaghat
title	Corneal biomechanical parameters in keratoconus eyes with abnormal elevation on the back corneal surface only versus both back and front surfaces
title_short	Corneal biomechanical parameters in keratoconus eyes with abnormal elevation on the back corneal surface only versus both back and front surfaces
title_full	Corneal biomechanical parameters in keratoconus eyes with abnormal elevation on the back corneal surface only versus both back and front surfaces
title_fullStr	Corneal biomechanical parameters in keratoconus eyes with abnormal elevation on the back corneal surface only versus both back and front surfaces
title_full_unstemmed	Corneal biomechanical parameters in keratoconus eyes with abnormal elevation on the back corneal surface only versus both back and front surfaces
title_sort	corneal biomechanical parameters in keratoconus eyes with abnormal elevation on the back corneal surface only versus both back and front surfaces
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c8cd64b034234d1fa373047c0bce6c71
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Corneal biomechanical parameters in keratoconus eyes with abnormal elevation on the back corneal surface only versus both back and front surfaces

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