Controversies in Podocyte Loss: Death or Detachment?

Glomerular podocytes are characterized by terminally differentiated epithelial cells with limited proliferating ability; thus, podocyte loss could not be fully compensated by podocyte regeneration. A large body of clinical studies collectively demonstrated that podocyte loss correlated with glomerul...

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Autores principales:	Lijun Yin, Lu Yu, John Cijiang He, Anqun Chen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	podocyte loss cell death detachment apoptosis autophagic cell death mitotic catastrophe Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c8ce5e4f1b2e4aa384b9e5f8c7053942
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spelling	oai:doaj.org-article:c8ce5e4f1b2e4aa384b9e5f8c70539422021-11-22T06:40:17ZControversies in Podocyte Loss: Death or Detachment?2296-634X10.3389/fcell.2021.771931https://doaj.org/article/c8ce5e4f1b2e4aa384b9e5f8c70539422021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.771931/fullhttps://doaj.org/toc/2296-634XGlomerular podocytes are characterized by terminally differentiated epithelial cells with limited proliferating ability; thus, podocyte loss could not be fully compensated by podocyte regeneration. A large body of clinical studies collectively demonstrated that podocyte loss correlated with glomerular diseases progression. Both podocyte death and podocyte detachment lead to podocyte loss; however, which one is the main cause remains controversial. Up to date, multiple mechanisms are involved in podocyte death, including programmed apoptotic cell death (apoptosis and anoikis), programmed nonapoptotic cell death (autophagy, entosis, and podoptosis), immune-related cell death (pyroptosis), and other types of cell death (necroptosis and mitotic catastrophe-related cell death). Apoptosis is considered a common mechanism of podocyte loss; however, most of the data were generated in vitro and the evidence of in vivo podocyte apoptosis is limited. The isolation of podocytes in the urine and subsequent culture of urinary podocytes in vitro suggest that detachment of viable podocytes could be another important mechanism for podocyte loss. In this review, we summarize recent advances that address this controversial topic on the specific circumstances of podocyte loss.Lijun YinLu YuLu YuJohn Cijiang HeJohn Cijiang HeAnqun ChenFrontiers Media S.A.articlepodocyte losscell deathdetachmentapoptosisautophagic cell deathmitotic catastropheBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	podocyte loss cell death detachment apoptosis autophagic cell death mitotic catastrophe Biology (General) QH301-705.5
spellingShingle	podocyte loss cell death detachment apoptosis autophagic cell death mitotic catastrophe Biology (General) QH301-705.5 Lijun Yin Lu Yu Lu Yu John Cijiang He John Cijiang He Anqun Chen Controversies in Podocyte Loss: Death or Detachment?
description	Glomerular podocytes are characterized by terminally differentiated epithelial cells with limited proliferating ability; thus, podocyte loss could not be fully compensated by podocyte regeneration. A large body of clinical studies collectively demonstrated that podocyte loss correlated with glomerular diseases progression. Both podocyte death and podocyte detachment lead to podocyte loss; however, which one is the main cause remains controversial. Up to date, multiple mechanisms are involved in podocyte death, including programmed apoptotic cell death (apoptosis and anoikis), programmed nonapoptotic cell death (autophagy, entosis, and podoptosis), immune-related cell death (pyroptosis), and other types of cell death (necroptosis and mitotic catastrophe-related cell death). Apoptosis is considered a common mechanism of podocyte loss; however, most of the data were generated in vitro and the evidence of in vivo podocyte apoptosis is limited. The isolation of podocytes in the urine and subsequent culture of urinary podocytes in vitro suggest that detachment of viable podocytes could be another important mechanism for podocyte loss. In this review, we summarize recent advances that address this controversial topic on the specific circumstances of podocyte loss.
format	article
author	Lijun Yin Lu Yu Lu Yu John Cijiang He John Cijiang He Anqun Chen
author_facet	Lijun Yin Lu Yu Lu Yu John Cijiang He John Cijiang He Anqun Chen
author_sort	Lijun Yin
title	Controversies in Podocyte Loss: Death or Detachment?
title_short	Controversies in Podocyte Loss: Death or Detachment?
title_full	Controversies in Podocyte Loss: Death or Detachment?
title_fullStr	Controversies in Podocyte Loss: Death or Detachment?
title_full_unstemmed	Controversies in Podocyte Loss: Death or Detachment?
title_sort	controversies in podocyte loss: death or detachment?
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c8ce5e4f1b2e4aa384b9e5f8c7053942
work_keys_str_mv	AT lijunyin controversiesinpodocytelossdeathordetachment AT luyu controversiesinpodocytelossdeathordetachment AT luyu controversiesinpodocytelossdeathordetachment AT johncijianghe controversiesinpodocytelossdeathordetachment AT johncijianghe controversiesinpodocytelossdeathordetachment AT anqunchen controversiesinpodocytelossdeathordetachment
_version_	1718418127291678720

Controversies in Podocyte Loss: Death or Detachment?

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