An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination

An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination

Chondroitin sulfate proteoglycans (CSPGs) secreted by astrocytes are known to inhibit OPC differentiation and remyelination. Here, the authors identify a novel CSPG synthesis inhibitor and find it can rescue OPC differentiation in vitroand accelerate remyelination in mice following focal demyelinati...

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Autores principales: Michael B. Keough, James A. Rogers, Ping Zhang, Samuel K. Jensen, Erin L. Stephenson, Tieyu Chen, Mitchel G. Hurlbert, Lorraine W. Lau, Khalil S. Rawji, Jason R. Plemel, Marcus Koch, Chang-Chun Ling, V. Wee Yong
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Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/c8cea3ee1dd24ffdbc91e88b7bd6d45a
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spelling oai:doaj.org-article:c8cea3ee1dd24ffdbc91e88b7bd6d45a2021-12-02T16:50:15ZAn inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination10.1038/ncomms113122041-1723https://doaj.org/article/c8cea3ee1dd24ffdbc91e88b7bd6d45a2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11312https://doaj.org/toc/2041-1723Chondroitin sulfate proteoglycans (CSPGs) secreted by astrocytes are known to inhibit OPC differentiation and remyelination. Here, the authors identify a novel CSPG synthesis inhibitor and find it can rescue OPC differentiation in vitroand accelerate remyelination in mice following focal demyelination.Michael B. KeoughJames A. RogersPing ZhangSamuel K. JensenErin L. StephensonTieyu ChenMitchel G. HurlbertLorraine W. LauKhalil S. RawjiJason R. PlemelMarcus KochChang-Chun LingV. Wee YongNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Michael B. Keough
James A. Rogers
Ping Zhang
Samuel K. Jensen
Erin L. Stephenson
Tieyu Chen
Mitchel G. Hurlbert
Lorraine W. Lau
Khalil S. Rawji
Jason R. Plemel
Marcus Koch
Chang-Chun Ling
V. Wee Yong
An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination
description Chondroitin sulfate proteoglycans (CSPGs) secreted by astrocytes are known to inhibit OPC differentiation and remyelination. Here, the authors identify a novel CSPG synthesis inhibitor and find it can rescue OPC differentiation in vitroand accelerate remyelination in mice following focal demyelination.
format article
author Michael B. Keough
James A. Rogers
Ping Zhang
Samuel K. Jensen
Erin L. Stephenson
Tieyu Chen
Mitchel G. Hurlbert
Lorraine W. Lau
Khalil S. Rawji
Jason R. Plemel
Marcus Koch
Chang-Chun Ling
V. Wee Yong
author_facet Michael B. Keough
James A. Rogers
Ping Zhang
Samuel K. Jensen
Erin L. Stephenson
Tieyu Chen
Mitchel G. Hurlbert
Lorraine W. Lau
Khalil S. Rawji
Jason R. Plemel
Marcus Koch
Chang-Chun Ling
V. Wee Yong
author_sort Michael B. Keough
title An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination
title_short An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination
title_full An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination
title_fullStr An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination
title_full_unstemmed An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination
title_sort inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/c8cea3ee1dd24ffdbc91e88b7bd6d45a
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