Senescent cell turnover slows with age providing an explanation for the Gompertz law

One of the underlying causes of aging is the accumulation of senescent cells, but their turnover rates and dynamics during ageing are unknown. Here the authors measure and model senescent cell production and removal and explore implications for mortality.

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Autores principales:	Omer Karin, Amit Agrawal, Ziv Porat, Valery Krizhanovsky, Uri Alon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c8d1148874e54b7f9c4cf46bb629afe1
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spelling	oai:doaj.org-article:c8d1148874e54b7f9c4cf46bb629afe12021-12-02T15:35:48ZSenescent cell turnover slows with age providing an explanation for the Gompertz law10.1038/s41467-019-13192-42041-1723https://doaj.org/article/c8d1148874e54b7f9c4cf46bb629afe12019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13192-4https://doaj.org/toc/2041-1723One of the underlying causes of aging is the accumulation of senescent cells, but their turnover rates and dynamics during ageing are unknown. Here the authors measure and model senescent cell production and removal and explore implications for mortality.Omer KarinAmit AgrawalZiv PoratValery KrizhanovskyUri AlonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Omer Karin Amit Agrawal Ziv Porat Valery Krizhanovsky Uri Alon Senescent cell turnover slows with age providing an explanation for the Gompertz law
description	One of the underlying causes of aging is the accumulation of senescent cells, but their turnover rates and dynamics during ageing are unknown. Here the authors measure and model senescent cell production and removal and explore implications for mortality.
format	article
author	Omer Karin Amit Agrawal Ziv Porat Valery Krizhanovsky Uri Alon
author_facet	Omer Karin Amit Agrawal Ziv Porat Valery Krizhanovsky Uri Alon
author_sort	Omer Karin
title	Senescent cell turnover slows with age providing an explanation for the Gompertz law
title_short	Senescent cell turnover slows with age providing an explanation for the Gompertz law
title_full	Senescent cell turnover slows with age providing an explanation for the Gompertz law
title_fullStr	Senescent cell turnover slows with age providing an explanation for the Gompertz law
title_full_unstemmed	Senescent cell turnover slows with age providing an explanation for the Gompertz law
title_sort	senescent cell turnover slows with age providing an explanation for the gompertz law
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c8d1148874e54b7f9c4cf46bb629afe1
work_keys_str_mv	AT omerkarin senescentcellturnoverslowswithageprovidinganexplanationforthegompertzlaw AT amitagrawal senescentcellturnoverslowswithageprovidinganexplanationforthegompertzlaw AT zivporat senescentcellturnoverslowswithageprovidinganexplanationforthegompertzlaw AT valerykrizhanovsky senescentcellturnoverslowswithageprovidinganexplanationforthegompertzlaw AT urialon senescentcellturnoverslowswithageprovidinganexplanationforthegompertzlaw
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Senescent cell turnover slows with age providing an explanation for the Gompertz law

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