A P-loop mutation in Gα subunits prevents transition to the active state: implications for G-protein signaling in fungal pathogenesis.

Heterotrimeric G-proteins are molecular switches integral to a panoply of different physiological responses that many organisms make to environmental cues. The switch from inactive to active Gαβγ heterotrimer relies on nucleotide cycling by the Gα subunit: exchange of GTP for GDP activates Gα, where...

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Autores principales: Dustin E Bosch, Francis S Willard, Ravikrishna Ramanujam, Adam J Kimple, Melinda D Willard, Naweed I Naqvi, David P Siderovski
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/c8d316eb8abe46629e2463a57a3ec01b
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