Functional activity and peripheral insulin resistance in patients with different types of onset of diabetes mellitus

Aim. To evaluate changes in functional activity and insulin resistance (IR) in patients with different types of onset of diabetes mellitus(DM). Materials and methods. We examined 166 subjects which were subdivided into 4 study groups and 1 control group. Assessment of totalbeta-cell functional act...

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Autores principales:	Tatiana Vasil'evna Nikonova, Elena Vladimirovna Pekareva, Ivan Ivanovich Dedov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2012
Materias:	lada homa diabetes mellitus insulin resistance Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/c8d421d330564d9590d80a23d5eacafa
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spelling	oai:doaj.org-article:c8d421d330564d9590d80a23d5eacafa2021-11-14T09:00:17ZFunctional activity and peripheral insulin resistance in patients with different types of onset of diabetes mellitus2072-03512072-037810.14341/2072-0351-6082https://doaj.org/article/c8d421d330564d9590d80a23d5eacafa2012-09-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6082https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To evaluate changes in functional activity and insulin resistance (IR) in patients with different types of onset of diabetes mellitus(DM). Materials and methods. We examined 166 subjects which were subdivided into 4 study groups and 1 control group. Assessment of totalbeta-cell functional activity and degree of IR (according to HOMA-model) was conducted in patients with different variants of DM onsetand in the group of high risk for type 1 DM. Results. The most significant decrease in beta-cell functional activity was found in patients with type 1 diabetes mellitus (HOMA-F 8.9%).Onset of LADA (Latent autoimmune diabetes in adults) and type 2 diabetes mellitus (T2DM) was also characterized by decreasein beta-cell functional activity (HOMA-F 39.2% and 63.9%, respectively), as well as by development of IR: HOMA-IR 3.7 and 7.2,respectively. Conclusion. Clinical onset of LADA and T2DM occurs against the background of decreased beta-cell functional activity and compromisedperipheral insulin sensitivity.Tatiana Vasil'evna NikonovaElena Vladimirovna PekarevaIvan Ivanovich DedovEndocrinology Research Centrearticleladahomadiabetes mellitusladainsulin resistancehomaNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 15, Iss 3, Pp 24-26 (2012)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	lada homa diabetes mellitus lada insulin resistance homa Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	lada homa diabetes mellitus lada insulin resistance homa Nutritional diseases. Deficiency diseases RC620-627 Tatiana Vasil'evna Nikonova Elena Vladimirovna Pekareva Ivan Ivanovich Dedov Functional activity and peripheral insulin resistance in patients with different types of onset of diabetes mellitus
description	Aim. To evaluate changes in functional activity and insulin resistance (IR) in patients with different types of onset of diabetes mellitus(DM). Materials and methods. We examined 166 subjects which were subdivided into 4 study groups and 1 control group. Assessment of totalbeta-cell functional activity and degree of IR (according to HOMA-model) was conducted in patients with different variants of DM onsetand in the group of high risk for type 1 DM. Results. The most significant decrease in beta-cell functional activity was found in patients with type 1 diabetes mellitus (HOMA-F 8.9%).Onset of LADA (Latent autoimmune diabetes in adults) and type 2 diabetes mellitus (T2DM) was also characterized by decreasein beta-cell functional activity (HOMA-F 39.2% and 63.9%, respectively), as well as by development of IR: HOMA-IR 3.7 and 7.2,respectively. Conclusion. Clinical onset of LADA and T2DM occurs against the background of decreased beta-cell functional activity and compromisedperipheral insulin sensitivity.
format	article
author	Tatiana Vasil'evna Nikonova Elena Vladimirovna Pekareva Ivan Ivanovich Dedov
author_facet	Tatiana Vasil'evna Nikonova Elena Vladimirovna Pekareva Ivan Ivanovich Dedov
author_sort	Tatiana Vasil'evna Nikonova
title	Functional activity and peripheral insulin resistance in patients with different types of onset of diabetes mellitus
title_short	Functional activity and peripheral insulin resistance in patients with different types of onset of diabetes mellitus
title_full	Functional activity and peripheral insulin resistance in patients with different types of onset of diabetes mellitus
title_fullStr	Functional activity and peripheral insulin resistance in patients with different types of onset of diabetes mellitus
title_full_unstemmed	Functional activity and peripheral insulin resistance in patients with different types of onset of diabetes mellitus
title_sort	functional activity and peripheral insulin resistance in patients with different types of onset of diabetes mellitus
publisher	Endocrinology Research Centre
publishDate	2012
url	https://doaj.org/article/c8d421d330564d9590d80a23d5eacafa
work_keys_str_mv	AT tatianavasilevnanikonova functionalactivityandperipheralinsulinresistanceinpatientswithdifferenttypesofonsetofdiabetesmellitus AT elenavladimirovnapekareva functionalactivityandperipheralinsulinresistanceinpatientswithdifferenttypesofonsetofdiabetesmellitus AT ivanivanovichdedov functionalactivityandperipheralinsulinresistanceinpatientswithdifferenttypesofonsetofdiabetesmellitus
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Functional activity and peripheral insulin resistance in patients with different types of onset of diabetes mellitus

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