Histology of neovascular myopic macular degeneration

Abstract To assess the histological correlate of neovascular or exudative myopic macular degeneration (nMMD) in highly myopic human eyes, we examined histomorphometrically histologic sections of enucleated eyes of Caucasian patients. The study included 284 eyes (age: 61.9 ± 13.7 years; range: 24–89 ...

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Autores principales:	Shefali B. Jonas, Songhomitra Panda-Jonas, Jost B. Jonas, Rahul A. Jonas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c8d49999db4f43cb9124a7a70366d5b7
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spelling	oai:doaj.org-article:c8d49999db4f43cb9124a7a70366d5b72021-11-14T12:18:00ZHistology of neovascular myopic macular degeneration10.1038/s41598-021-01500-22045-2322https://doaj.org/article/c8d49999db4f43cb9124a7a70366d5b72021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01500-2https://doaj.org/toc/2045-2322Abstract To assess the histological correlate of neovascular or exudative myopic macular degeneration (nMMD) in highly myopic human eyes, we examined histomorphometrically histologic sections of enucleated eyes of Caucasian patients. The study included 284 eyes (age: 61.9 ± 13.7 years; range: 24–89 years; axial length: 25.5 ± 3.1 mm; range: 20–37 mm). An nMMD was detected in 5 eyes (axial length: 29.6 ± 2.6 mm; range: 26.0–31.0 mm). All these eyes showed within or close to the nMMD a macular Bruch’s membrane (BM) defect, fibrous tissue with erythrocyte-filled blood vessels, and proliferations of irregularly pigmented and irregularly piled-up retinal pigment epithelium (RPE) cells each of which was connected with a curled-up, PAS (Periodic-Acid-Shiff)-positive membrane. The nMMD lesions were covered by proliferated RPE cells. RPE cells were not detected within the retina. In binary regression analysis, a higher nMMD prevalence was associated with a higher prevalence of macular BM defects (odds ratio: > 1000; P < 0.001), while the association with axial length was not significant (P = 0.43) in that model. After adjustment for the presence of macular BM defects, the nMMD prevalence was not associated with BM thickness (measured at the posterior pole, equator-posterior pole midpoint, equator and shortly posterior to the ora serrata) (P = 0.10; P = 0.87; P = 0.40; and P = 0.36, respectively), RPE cell layer thickness (P = 0.83; P = 0.79; P = 0.31; P = 0.38, resp.), RPE cell density (P = 0.56; P = 0.91; P = 0.47; P = 0.87, resp.), choriocapillaris thickness (P = 0.47; P = 0.93; P = 0.41; P = 0.75, resp.), and choriocapillaris density (P = 0.99; P = 0.94; P = 0.17; P = 0.97, resp.). The results suggest that nMMD is characterized by a fibrous pseudo-metaplasia of the RPE and is strongly associated with macular BM defects, without other detected histomorphometric differences in thickness or density of the RPE, BM, and choriocapillaris.Shefali B. JonasSonghomitra Panda-JonasJost B. JonasRahul A. JonasNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shefali B. Jonas Songhomitra Panda-Jonas Jost B. Jonas Rahul A. Jonas Histology of neovascular myopic macular degeneration
description	Abstract To assess the histological correlate of neovascular or exudative myopic macular degeneration (nMMD) in highly myopic human eyes, we examined histomorphometrically histologic sections of enucleated eyes of Caucasian patients. The study included 284 eyes (age: 61.9 ± 13.7 years; range: 24–89 years; axial length: 25.5 ± 3.1 mm; range: 20–37 mm). An nMMD was detected in 5 eyes (axial length: 29.6 ± 2.6 mm; range: 26.0–31.0 mm). All these eyes showed within or close to the nMMD a macular Bruch’s membrane (BM) defect, fibrous tissue with erythrocyte-filled blood vessels, and proliferations of irregularly pigmented and irregularly piled-up retinal pigment epithelium (RPE) cells each of which was connected with a curled-up, PAS (Periodic-Acid-Shiff)-positive membrane. The nMMD lesions were covered by proliferated RPE cells. RPE cells were not detected within the retina. In binary regression analysis, a higher nMMD prevalence was associated with a higher prevalence of macular BM defects (odds ratio: > 1000; P < 0.001), while the association with axial length was not significant (P = 0.43) in that model. After adjustment for the presence of macular BM defects, the nMMD prevalence was not associated with BM thickness (measured at the posterior pole, equator-posterior pole midpoint, equator and shortly posterior to the ora serrata) (P = 0.10; P = 0.87; P = 0.40; and P = 0.36, respectively), RPE cell layer thickness (P = 0.83; P = 0.79; P = 0.31; P = 0.38, resp.), RPE cell density (P = 0.56; P = 0.91; P = 0.47; P = 0.87, resp.), choriocapillaris thickness (P = 0.47; P = 0.93; P = 0.41; P = 0.75, resp.), and choriocapillaris density (P = 0.99; P = 0.94; P = 0.17; P = 0.97, resp.). The results suggest that nMMD is characterized by a fibrous pseudo-metaplasia of the RPE and is strongly associated with macular BM defects, without other detected histomorphometric differences in thickness or density of the RPE, BM, and choriocapillaris.
format	article
author	Shefali B. Jonas Songhomitra Panda-Jonas Jost B. Jonas Rahul A. Jonas
author_facet	Shefali B. Jonas Songhomitra Panda-Jonas Jost B. Jonas Rahul A. Jonas
author_sort	Shefali B. Jonas
title	Histology of neovascular myopic macular degeneration
title_short	Histology of neovascular myopic macular degeneration
title_full	Histology of neovascular myopic macular degeneration
title_fullStr	Histology of neovascular myopic macular degeneration
title_full_unstemmed	Histology of neovascular myopic macular degeneration
title_sort	histology of neovascular myopic macular degeneration
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c8d49999db4f43cb9124a7a70366d5b7
work_keys_str_mv	AT shefalibjonas histologyofneovascularmyopicmaculardegeneration AT songhomitrapandajonas histologyofneovascularmyopicmaculardegeneration AT jostbjonas histologyofneovascularmyopicmaculardegeneration AT rahulajonas histologyofneovascularmyopicmaculardegeneration
_version_	1718429315141468160

Histology of neovascular myopic macular degeneration

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