Hydrophilic mesoporous carbon nanospheres with high drug-loading efficiency for doxorubicin delivery and cancer therapy

Huan Wang,1,2,* Xiangui Li,1,* Zhiqiang Ma,1 Dan Wang,3 Linzhao Wang,1,2 Jieqiong Zhan,1,4 Lan She,1 Feng Yang1 1Department of Inorganic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, 2Department of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, 3...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wang H, Li X, Ma Z, Wang D, Wang L, Zhan J, She L, Yang F
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	drug delivery hydrophilic mesoporous carbon nanoparticles tumour metastasis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c8d747f9a91345fa9c033f23bff4d4e2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c8d747f9a91345fa9c033f23bff4d4e2
record_format	dspace
spelling	oai:doaj.org-article:c8d747f9a91345fa9c033f23bff4d4e22021-12-02T02:04:16ZHydrophilic mesoporous carbon nanospheres with high drug-loading efficiency for doxorubicin delivery and cancer therapy1178-2013https://doaj.org/article/c8d747f9a91345fa9c033f23bff4d4e22016-04-01T00:00:00Zhttps://www.dovepress.com/hydrophilic-mesoporous-carbon-nanospheres-with-high-drug-loading-effic-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Huan Wang,1,2,* Xiangui Li,1,* Zhiqiang Ma,1 Dan Wang,3 Linzhao Wang,1,2 Jieqiong Zhan,1,4 Lan She,1 Feng Yang1 1Department of Inorganic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, 2Department of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, 3Department of Obstetrics and Gynecology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, 4Department of Pharmacy, Hebei North University, Zhangjiakou, Hebei, People’s Republic of China *These authors contributed equally to this article Abstract: In this study, a highly effective transmembrane delivery vehicle based on PEGylated oxidized mesoporous carbon nanosphere (oMCN@PEG) was successfully fabricated in a facile strategy. oMCN@PEG exhibited a narrow size distribution of 90 nm, excellent hydrophilicity, good biocompatibility, and a very high loading efficiency for doxorubicin (DOX). The drug system (oMCN@DOX@PEG) exhibited excellent stability under neutral pH conditions, but with dramatic releases of DOX at reduced pH conditions. Pharmacokinetics study revealed that oMCN@DOX@PEG could prolong the circulation of DOX in the blood stream. The endocytosis, cytotoxicity, and anticancer effect in vitro and in vivo of the drug-loaded nanoparticles were also evaluated. Our results showed that the nanoparticles efficiently penetrated the membrane of tumor cells, subsequently released drugs, and efficiently inhibited the growth of cancer cells both in vitro and in vivo. Especially, oMCN@DOX@PEG also exhibited significant antimetastasis effect in advanced stage of malignant cancer, improving the survival time of tumor-bearing mice. The results suggested that oMCN@PEG might be a promising anticancer drug delivery vehicle for cancer therapy. Keywords: drug delivery, hydrophilic, mesoporous carbon nanoparticles, tumor metastasisWang HLi XMa ZWang DWang LZhan JShe LYang FDove Medical Pressarticledrug deliveryhydrophilicmesoporous carbon nanoparticlestumour metastasisMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 1793-1806 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	drug delivery hydrophilic mesoporous carbon nanoparticles tumour metastasis Medicine (General) R5-920
spellingShingle	drug delivery hydrophilic mesoporous carbon nanoparticles tumour metastasis Medicine (General) R5-920 Wang H Li X Ma Z Wang D Wang L Zhan J She L Yang F Hydrophilic mesoporous carbon nanospheres with high drug-loading efficiency for doxorubicin delivery and cancer therapy
description	Huan Wang,1,2,* Xiangui Li,1,* Zhiqiang Ma,1 Dan Wang,3 Linzhao Wang,1,2 Jieqiong Zhan,1,4 Lan She,1 Feng Yang1 1Department of Inorganic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, 2Department of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou, 3Department of Obstetrics and Gynecology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, 4Department of Pharmacy, Hebei North University, Zhangjiakou, Hebei, People’s Republic of China *These authors contributed equally to this article Abstract: In this study, a highly effective transmembrane delivery vehicle based on PEGylated oxidized mesoporous carbon nanosphere (oMCN@PEG) was successfully fabricated in a facile strategy. oMCN@PEG exhibited a narrow size distribution of 90 nm, excellent hydrophilicity, good biocompatibility, and a very high loading efficiency for doxorubicin (DOX). The drug system (oMCN@DOX@PEG) exhibited excellent stability under neutral pH conditions, but with dramatic releases of DOX at reduced pH conditions. Pharmacokinetics study revealed that oMCN@DOX@PEG could prolong the circulation of DOX in the blood stream. The endocytosis, cytotoxicity, and anticancer effect in vitro and in vivo of the drug-loaded nanoparticles were also evaluated. Our results showed that the nanoparticles efficiently penetrated the membrane of tumor cells, subsequently released drugs, and efficiently inhibited the growth of cancer cells both in vitro and in vivo. Especially, oMCN@DOX@PEG also exhibited significant antimetastasis effect in advanced stage of malignant cancer, improving the survival time of tumor-bearing mice. The results suggested that oMCN@PEG might be a promising anticancer drug delivery vehicle for cancer therapy. Keywords: drug delivery, hydrophilic, mesoporous carbon nanoparticles, tumor metastasis
format	article
author	Wang H Li X Ma Z Wang D Wang L Zhan J She L Yang F
author_facet	Wang H Li X Ma Z Wang D Wang L Zhan J She L Yang F
author_sort	Wang H
title	Hydrophilic mesoporous carbon nanospheres with high drug-loading efficiency for doxorubicin delivery and cancer therapy
title_short	Hydrophilic mesoporous carbon nanospheres with high drug-loading efficiency for doxorubicin delivery and cancer therapy
title_full	Hydrophilic mesoporous carbon nanospheres with high drug-loading efficiency for doxorubicin delivery and cancer therapy
title_fullStr	Hydrophilic mesoporous carbon nanospheres with high drug-loading efficiency for doxorubicin delivery and cancer therapy
title_full_unstemmed	Hydrophilic mesoporous carbon nanospheres with high drug-loading efficiency for doxorubicin delivery and cancer therapy
title_sort	hydrophilic mesoporous carbon nanospheres with high drug-loading efficiency for doxorubicin delivery and cancer therapy
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/c8d747f9a91345fa9c033f23bff4d4e2
work_keys_str_mv	AT wangh hydrophilicmesoporouscarbonnanosphereswithhighdrugloadingefficiencyfordoxorubicindeliveryandcancertherapy AT lix hydrophilicmesoporouscarbonnanosphereswithhighdrugloadingefficiencyfordoxorubicindeliveryandcancertherapy AT maz hydrophilicmesoporouscarbonnanosphereswithhighdrugloadingefficiencyfordoxorubicindeliveryandcancertherapy AT wangd hydrophilicmesoporouscarbonnanosphereswithhighdrugloadingefficiencyfordoxorubicindeliveryandcancertherapy AT wangl hydrophilicmesoporouscarbonnanosphereswithhighdrugloadingefficiencyfordoxorubicindeliveryandcancertherapy AT zhanj hydrophilicmesoporouscarbonnanosphereswithhighdrugloadingefficiencyfordoxorubicindeliveryandcancertherapy AT shel hydrophilicmesoporouscarbonnanosphereswithhighdrugloadingefficiencyfordoxorubicindeliveryandcancertherapy AT yangf hydrophilicmesoporouscarbonnanosphereswithhighdrugloadingefficiencyfordoxorubicindeliveryandcancertherapy
_version_	1718402735182708736

Hydrophilic mesoporous carbon nanospheres with high drug-loading efficiency for doxorubicin delivery and cancer therapy

Ejemplares similares