Therapeutic Response-Based Reclassification of Multiple Tumor Subtypes Reveals Intrinsic Molecular Concordance of Therapy Across Histologically Disparate Cancers

Cancers that are histologically defined as the same type of cancer often need a distinct therapy based on underlying heterogeneity; likewise, histologically disparate cancers can require similar treatment approaches due to intrinsic similarities. A comprehensive analysis integrated with drug respons...

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Autores principales:	Yue Xu, Jie Zheng, Zhaoqing Cai, Wang Li, Jens Köhler, Yao Dai, Xiaojie Cheng, Tao Wu, Fan Zhang, Haiyun Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	tumor classification OMICS data pharmacological subtypes precision medicine CGP dataset Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c8d823ef35b04cdd825568627acadcae
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spelling	oai:doaj.org-article:c8d823ef35b04cdd825568627acadcae2021-11-12T05:20:55ZTherapeutic Response-Based Reclassification of Multiple Tumor Subtypes Reveals Intrinsic Molecular Concordance of Therapy Across Histologically Disparate Cancers2296-634X10.3389/fcell.2021.773101https://doaj.org/article/c8d823ef35b04cdd825568627acadcae2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.773101/fullhttps://doaj.org/toc/2296-634XCancers that are histologically defined as the same type of cancer often need a distinct therapy based on underlying heterogeneity; likewise, histologically disparate cancers can require similar treatment approaches due to intrinsic similarities. A comprehensive analysis integrated with drug response data and molecular alterations, particularly to reveal therapeutic concordance mechanisms across histologically disparate tumor subtypes, has not yet been fully exploited. In this study, we integrated pharmacological, genomic, and transcriptomic profiling data provided from the Cancer Genome Project (CGP) in a systematic in silico investigation of the pharmacological subtypes of cancers and the intrinsic concordance of molecular mechanisms leading to similar therapeutic responses across histologically disparate tumor subtypes. We further developed a novel approach to redefine cell-to-cell similarity and drug-to-drug similarity from the therapeutic concordance, providing a new point of view to study cancer heterogeneity. This study demonstrates how pharmacological and omics data can be used to systematically classify cancers in terms of response to various compounds and provides us with a purely therapy-oriented perspective to view tumor classifications independent of histology subtypes. The knowledge of pharmacological subtypes of 367 drugs are available via our website (http://www.hywanglab.cn/dtdb/), providing the resources for precision medicine in the perspective of therapeutic response-based re-classification of tumor.Yue XuJie ZhengZhaoqing CaiWang LiJens KöhlerYao DaiXiaojie ChengTao WuFan ZhangFan ZhangHaiyun WangFrontiers Media S.A.articletumor classificationOMICS datapharmacological subtypesprecision medicineCGP datasetBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tumor classification OMICS data pharmacological subtypes precision medicine CGP dataset Biology (General) QH301-705.5
spellingShingle	tumor classification OMICS data pharmacological subtypes precision medicine CGP dataset Biology (General) QH301-705.5 Yue Xu Jie Zheng Zhaoqing Cai Wang Li Jens Köhler Yao Dai Xiaojie Cheng Tao Wu Fan Zhang Fan Zhang Haiyun Wang Therapeutic Response-Based Reclassification of Multiple Tumor Subtypes Reveals Intrinsic Molecular Concordance of Therapy Across Histologically Disparate Cancers
description	Cancers that are histologically defined as the same type of cancer often need a distinct therapy based on underlying heterogeneity; likewise, histologically disparate cancers can require similar treatment approaches due to intrinsic similarities. A comprehensive analysis integrated with drug response data and molecular alterations, particularly to reveal therapeutic concordance mechanisms across histologically disparate tumor subtypes, has not yet been fully exploited. In this study, we integrated pharmacological, genomic, and transcriptomic profiling data provided from the Cancer Genome Project (CGP) in a systematic in silico investigation of the pharmacological subtypes of cancers and the intrinsic concordance of molecular mechanisms leading to similar therapeutic responses across histologically disparate tumor subtypes. We further developed a novel approach to redefine cell-to-cell similarity and drug-to-drug similarity from the therapeutic concordance, providing a new point of view to study cancer heterogeneity. This study demonstrates how pharmacological and omics data can be used to systematically classify cancers in terms of response to various compounds and provides us with a purely therapy-oriented perspective to view tumor classifications independent of histology subtypes. The knowledge of pharmacological subtypes of 367 drugs are available via our website (http://www.hywanglab.cn/dtdb/), providing the resources for precision medicine in the perspective of therapeutic response-based re-classification of tumor.
format	article
author	Yue Xu Jie Zheng Zhaoqing Cai Wang Li Jens Köhler Yao Dai Xiaojie Cheng Tao Wu Fan Zhang Fan Zhang Haiyun Wang
author_facet	Yue Xu Jie Zheng Zhaoqing Cai Wang Li Jens Köhler Yao Dai Xiaojie Cheng Tao Wu Fan Zhang Fan Zhang Haiyun Wang
author_sort	Yue Xu
title	Therapeutic Response-Based Reclassification of Multiple Tumor Subtypes Reveals Intrinsic Molecular Concordance of Therapy Across Histologically Disparate Cancers
title_short	Therapeutic Response-Based Reclassification of Multiple Tumor Subtypes Reveals Intrinsic Molecular Concordance of Therapy Across Histologically Disparate Cancers
title_full	Therapeutic Response-Based Reclassification of Multiple Tumor Subtypes Reveals Intrinsic Molecular Concordance of Therapy Across Histologically Disparate Cancers
title_fullStr	Therapeutic Response-Based Reclassification of Multiple Tumor Subtypes Reveals Intrinsic Molecular Concordance of Therapy Across Histologically Disparate Cancers
title_full_unstemmed	Therapeutic Response-Based Reclassification of Multiple Tumor Subtypes Reveals Intrinsic Molecular Concordance of Therapy Across Histologically Disparate Cancers
title_sort	therapeutic response-based reclassification of multiple tumor subtypes reveals intrinsic molecular concordance of therapy across histologically disparate cancers
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c8d823ef35b04cdd825568627acadcae
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Therapeutic Response-Based Reclassification of Multiple Tumor Subtypes Reveals Intrinsic Molecular Concordance of Therapy Across Histologically Disparate Cancers

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