Elevated Glucagon-like Peptide-1 and a Th2 Shift May Support Reduced Prevalence of Thoracic Aortic Aneurysm in Patients with Diabetes

Glucagon-like peptide-1 (GLP-1) regulates processes involved in the pathophysiology of thoracic aortic aneurysms (TAAs), including inflammation, while protecting against aortic aneurysms in animal models. Type 2 diabetes (T2D) involves altered GLP-1 signaling due to pathology and/or therapy and is a...

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Autores principales: Stelia Ntika, Harshitha Jois, Karin Lång, Christian Olsson, Anders Franco-Cereceda, Hanna M. Björck, Camilla Krizhanovskii
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Publicado: MDPI AG 2021
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spelling oai:doaj.org-article:c8db087a40f341e28b618294f0b321a12021-11-25T18:00:17ZElevated Glucagon-like Peptide-1 and a Th2 Shift May Support Reduced Prevalence of Thoracic Aortic Aneurysm in Patients with Diabetes10.3390/jcdd81101432308-3425https://doaj.org/article/c8db087a40f341e28b618294f0b321a12021-10-01T00:00:00Zhttps://www.mdpi.com/2308-3425/8/11/143https://doaj.org/toc/2308-3425Glucagon-like peptide-1 (GLP-1) regulates processes involved in the pathophysiology of thoracic aortic aneurysms (TAAs), including inflammation, while protecting against aortic aneurysms in animal models. Type 2 diabetes (T2D) involves altered GLP-1 signaling due to pathology and/or therapy and is associated with reduced prevalence of TAAs. We aimed to assess whether T2D alters the inflammatory profile/proteolytic activity, possible correlations to elevated fasting GLP-1 (F-GLP-1), and its relevance for TAA. F-GLP-1, pro-inflammatory T helper 1 (Th1) cytokines, Th2 cytokines, C-reactive protein, and matrix metalloproteinase-2 activity (MMP-2) were analyzed in surgical patients with aortic valve pathology with/without T2D and without T2D but with TAA. Patients with T2D displayed an increase in the relative systemic expression of interleukin 6 and tumor necrosis factor α and a clear trend towards reduced levels of interferon γ (IFNγ). In addition, a positive association between GLP-1 and the plasma interleukin 4 (IL-4)/IFNγ ratio was detected. TAA was associated with significantly lower plasma levels of the Th2 cytokines IL-4 and interleukin 5. Plasma MMP-2 activity did not differ between groups. We conclude that T2D involved a Th2 shift, which associates with elevated F-GLP-1 and may—considering Th1 bias in TAA—contribute to reduced prevalence of TAA in T2D.Stelia NtikaHarshitha JoisKarin LångChristian OlssonAnders Franco-CerecedaHanna M. BjörckCamilla KrizhanovskiiMDPI AGarticleaneurysmtype 2 diabetesglucagon-like peptide-1inflammationcytokinesDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of Cardiovascular Development and Disease, Vol 8, Iss 143, p 143 (2021)
institution DOAJ
collection DOAJ
language EN
topic aneurysm
type 2 diabetes
glucagon-like peptide-1
inflammation
cytokines
Diseases of the circulatory (Cardiovascular) system
RC666-701
spellingShingle aneurysm
type 2 diabetes
glucagon-like peptide-1
inflammation
cytokines
Diseases of the circulatory (Cardiovascular) system
RC666-701
Stelia Ntika
Harshitha Jois
Karin Lång
Christian Olsson
Anders Franco-Cereceda
Hanna M. Björck
Camilla Krizhanovskii
Elevated Glucagon-like Peptide-1 and a Th2 Shift May Support Reduced Prevalence of Thoracic Aortic Aneurysm in Patients with Diabetes
description Glucagon-like peptide-1 (GLP-1) regulates processes involved in the pathophysiology of thoracic aortic aneurysms (TAAs), including inflammation, while protecting against aortic aneurysms in animal models. Type 2 diabetes (T2D) involves altered GLP-1 signaling due to pathology and/or therapy and is associated with reduced prevalence of TAAs. We aimed to assess whether T2D alters the inflammatory profile/proteolytic activity, possible correlations to elevated fasting GLP-1 (F-GLP-1), and its relevance for TAA. F-GLP-1, pro-inflammatory T helper 1 (Th1) cytokines, Th2 cytokines, C-reactive protein, and matrix metalloproteinase-2 activity (MMP-2) were analyzed in surgical patients with aortic valve pathology with/without T2D and without T2D but with TAA. Patients with T2D displayed an increase in the relative systemic expression of interleukin 6 and tumor necrosis factor α and a clear trend towards reduced levels of interferon γ (IFNγ). In addition, a positive association between GLP-1 and the plasma interleukin 4 (IL-4)/IFNγ ratio was detected. TAA was associated with significantly lower plasma levels of the Th2 cytokines IL-4 and interleukin 5. Plasma MMP-2 activity did not differ between groups. We conclude that T2D involved a Th2 shift, which associates with elevated F-GLP-1 and may—considering Th1 bias in TAA—contribute to reduced prevalence of TAA in T2D.
format article
author Stelia Ntika
Harshitha Jois
Karin Lång
Christian Olsson
Anders Franco-Cereceda
Hanna M. Björck
Camilla Krizhanovskii
author_facet Stelia Ntika
Harshitha Jois
Karin Lång
Christian Olsson
Anders Franco-Cereceda
Hanna M. Björck
Camilla Krizhanovskii
author_sort Stelia Ntika
title Elevated Glucagon-like Peptide-1 and a Th2 Shift May Support Reduced Prevalence of Thoracic Aortic Aneurysm in Patients with Diabetes
title_short Elevated Glucagon-like Peptide-1 and a Th2 Shift May Support Reduced Prevalence of Thoracic Aortic Aneurysm in Patients with Diabetes
title_full Elevated Glucagon-like Peptide-1 and a Th2 Shift May Support Reduced Prevalence of Thoracic Aortic Aneurysm in Patients with Diabetes
title_fullStr Elevated Glucagon-like Peptide-1 and a Th2 Shift May Support Reduced Prevalence of Thoracic Aortic Aneurysm in Patients with Diabetes
title_full_unstemmed Elevated Glucagon-like Peptide-1 and a Th2 Shift May Support Reduced Prevalence of Thoracic Aortic Aneurysm in Patients with Diabetes
title_sort elevated glucagon-like peptide-1 and a th2 shift may support reduced prevalence of thoracic aortic aneurysm in patients with diabetes
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/c8db087a40f341e28b618294f0b321a1
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