In vivo imaging and tracking of exosomes for theranostics

Exosomes are lipid bilayer vesicles released by cells and serve as natural carriers for cell–cell communication. Exosomes provide a promising approach to the diagnosis and treatment of diseases and are considered as an alternative to cell therapy. However, one main restriction in their clinical appl...

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Autores principales:	Ning Ma, Changfeng Wu, Zihui Meng
Formato:	article
Lenguaje:	EN
Publicado:	World Scientific Publishing 2021
Materias:	exosomes labeling tracking in vivo imaging Technology T Optics. Light QC350-467
Acceso en línea:	https://doaj.org/article/c8e2095b4fb24a8a83608b60228873cc
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spelling	oai:doaj.org-article:c8e2095b4fb24a8a83608b60228873cc2021-11-23T13:04:53ZIn vivo imaging and tracking of exosomes for theranostics1793-54581793-720510.1142/S1793545821300056https://doaj.org/article/c8e2095b4fb24a8a83608b60228873cc2021-11-01T00:00:00Zhttp://www.worldscientific.com/doi/epdf/10.1142/S1793545821300056https://doaj.org/toc/1793-5458https://doaj.org/toc/1793-7205Exosomes are lipid bilayer vesicles released by cells and serve as natural carriers for cell–cell communication. Exosomes provide a promising approach to the diagnosis and treatment of diseases and are considered as an alternative to cell therapy. However, one main restriction in their clinical application is that the current understanding of these vesicles, especially their in vivo behaviors and distributions, remains inadequate. Here, we reviewed the current and emerging methods for in vivo imaging and tracking of exosomes, including fluorescence imaging, bioluminescence imaging, nuclear imaging, X-ray imaging, magnetic resonance imaging, photoacoustic imaging, and multimodal imaging. In vivo imaging and tracking of exosomes by these methods can help researchers further understand their uptake mechanism, biodistribution, migration, function, and therapeutic performance. The pioneering studies in this field can elucidate many unknown exosomal behaviors at different levels. We discussed the advantages and limitations of each labeling and imaging strategy. The advances in labeling and in vivo imaging will expand our understanding of exosomes and promote their clinical application. We finally provide a perspective and discuss several important issues that need to be explored in future research. This review highlights the values of efficient, sensitive, and biocompatible exosome labeling and imaging techniques in disease theranostics.Ning MaChangfeng WuZihui MengWorld Scientific Publishingarticleexosomeslabelingtrackingin vivo imagingTechnologyTOptics. LightQC350-467ENJournal of Innovative Optical Health Sciences, Vol 14, Iss 6, Pp 2130005-1-2130005-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	exosomes labeling tracking in vivo imaging Technology T Optics. Light QC350-467
spellingShingle	exosomes labeling tracking in vivo imaging Technology T Optics. Light QC350-467 Ning Ma Changfeng Wu Zihui Meng In vivo imaging and tracking of exosomes for theranostics
description	Exosomes are lipid bilayer vesicles released by cells and serve as natural carriers for cell–cell communication. Exosomes provide a promising approach to the diagnosis and treatment of diseases and are considered as an alternative to cell therapy. However, one main restriction in their clinical application is that the current understanding of these vesicles, especially their in vivo behaviors and distributions, remains inadequate. Here, we reviewed the current and emerging methods for in vivo imaging and tracking of exosomes, including fluorescence imaging, bioluminescence imaging, nuclear imaging, X-ray imaging, magnetic resonance imaging, photoacoustic imaging, and multimodal imaging. In vivo imaging and tracking of exosomes by these methods can help researchers further understand their uptake mechanism, biodistribution, migration, function, and therapeutic performance. The pioneering studies in this field can elucidate many unknown exosomal behaviors at different levels. We discussed the advantages and limitations of each labeling and imaging strategy. The advances in labeling and in vivo imaging will expand our understanding of exosomes and promote their clinical application. We finally provide a perspective and discuss several important issues that need to be explored in future research. This review highlights the values of efficient, sensitive, and biocompatible exosome labeling and imaging techniques in disease theranostics.
format	article
author	Ning Ma Changfeng Wu Zihui Meng
author_facet	Ning Ma Changfeng Wu Zihui Meng
author_sort	Ning Ma
title	In vivo imaging and tracking of exosomes for theranostics
title_short	In vivo imaging and tracking of exosomes for theranostics
title_full	In vivo imaging and tracking of exosomes for theranostics
title_fullStr	In vivo imaging and tracking of exosomes for theranostics
title_full_unstemmed	In vivo imaging and tracking of exosomes for theranostics
title_sort	in vivo imaging and tracking of exosomes for theranostics
publisher	World Scientific Publishing
publishDate	2021
url	https://doaj.org/article/c8e2095b4fb24a8a83608b60228873cc
work_keys_str_mv	AT ningma invivoimagingandtrackingofexosomesfortheranostics AT changfengwu invivoimagingandtrackingofexosomesfortheranostics AT zihuimeng invivoimagingandtrackingofexosomesfortheranostics
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In vivo imaging and tracking of exosomes for theranostics

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