Role of phosphodiesterase 5 in synaptic plasticity and memory

Daniela Puzzo1,2, Salvatore Sapienza1, Ottavio Arancio2, Agostino Palmeri11Dept of Physiological Sciences, University of Catania, Catania, Italy; 2Dept of Pathology, Taub Institute for Research on Alzheimer&rsquo;s Disease and the Aging Brain, Columbia University, New York, NY, USAAbstract:...

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Autores principales:	Daniela Puzzo, Salvatore Sapienza, Ottavio Arancio, Agostino Palmeri
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/c8e2691e7a18446dbaf233fd15c69b3b
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spelling	oai:doaj.org-article:c8e2691e7a18446dbaf233fd15c69b3b2021-12-02T01:58:22ZRole of phosphodiesterase 5 in synaptic plasticity and memory1176-63281178-2021https://doaj.org/article/c8e2691e7a18446dbaf233fd15c69b3b2008-04-01T00:00:00Zhttp://www.dovepress.com/role-of-phosphodiesterase-5-in-synaptic-plasticity-and-memory-a1036https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Daniela Puzzo1,2, Salvatore Sapienza1, Ottavio Arancio2, Agostino Palmeri11Dept of Physiological Sciences, University of Catania, Catania, Italy; 2Dept of Pathology, Taub Institute for Research on Alzheimer&rsquo;s Disease and the Aging Brain, Columbia University, New York, NY, USAAbstract: Phosphodiesterases (PDEs) are enzymes that break down the phosphodiesteric bond of the cyclic nucleotides, cAMP and cGMP, second messengers that regulate many biological processes. PDEs participate in the regulation of signal transduction by means of a fine regulation of cyclic nucleotides so that the response to cell stimuli is both specific and activates the correct third messengers. Several PDE inhibitors have been developed and used as therapeutic agents because they increase cyclic nucleotide levels by blocking the PDE function. In particular, sildenafil, an inhibitor of PDE5, has been mainly used in the treatment of erectile dysfunction but is now also utilized against pulmonary hypertension. This review examines the physiological role of PDE5 in synaptic plasticity and memory and the use of PDE5 inhibitors as possible therapeutic agents against disorders of the central nervous system (CNS).Keywords: phosphodiesterase 5, NO/cGMP pathway, sildenafil, synaptic plasticity, memory, Alzheimer&rsquo;s disease Daniela PuzzoSalvatore SapienzaOttavio ArancioAgostino PalmeriDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 2, Pp 371-387 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Daniela Puzzo Salvatore Sapienza Ottavio Arancio Agostino Palmeri Role of phosphodiesterase 5 in synaptic plasticity and memory
description	Daniela Puzzo1,2, Salvatore Sapienza1, Ottavio Arancio2, Agostino Palmeri11Dept of Physiological Sciences, University of Catania, Catania, Italy; 2Dept of Pathology, Taub Institute for Research on Alzheimer&rsquo;s Disease and the Aging Brain, Columbia University, New York, NY, USAAbstract: Phosphodiesterases (PDEs) are enzymes that break down the phosphodiesteric bond of the cyclic nucleotides, cAMP and cGMP, second messengers that regulate many biological processes. PDEs participate in the regulation of signal transduction by means of a fine regulation of cyclic nucleotides so that the response to cell stimuli is both specific and activates the correct third messengers. Several PDE inhibitors have been developed and used as therapeutic agents because they increase cyclic nucleotide levels by blocking the PDE function. In particular, sildenafil, an inhibitor of PDE5, has been mainly used in the treatment of erectile dysfunction but is now also utilized against pulmonary hypertension. This review examines the physiological role of PDE5 in synaptic plasticity and memory and the use of PDE5 inhibitors as possible therapeutic agents against disorders of the central nervous system (CNS).Keywords: phosphodiesterase 5, NO/cGMP pathway, sildenafil, synaptic plasticity, memory, Alzheimer&rsquo;s disease
format	article
author	Daniela Puzzo Salvatore Sapienza Ottavio Arancio Agostino Palmeri
author_facet	Daniela Puzzo Salvatore Sapienza Ottavio Arancio Agostino Palmeri
author_sort	Daniela Puzzo
title	Role of phosphodiesterase 5 in synaptic plasticity and memory
title_short	Role of phosphodiesterase 5 in synaptic plasticity and memory
title_full	Role of phosphodiesterase 5 in synaptic plasticity and memory
title_fullStr	Role of phosphodiesterase 5 in synaptic plasticity and memory
title_full_unstemmed	Role of phosphodiesterase 5 in synaptic plasticity and memory
title_sort	role of phosphodiesterase 5 in synaptic plasticity and memory
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/c8e2691e7a18446dbaf233fd15c69b3b
work_keys_str_mv	AT danielapuzzo roleofphosphodiesterase5insynapticplasticityandmemory AT salvatoresapienza roleofphosphodiesterase5insynapticplasticityandmemory AT ottavioarancio roleofphosphodiesterase5insynapticplasticityandmemory AT agostinopalmeri roleofphosphodiesterase5insynapticplasticityandmemory
_version_	1718402802487656448

Role of phosphodiesterase 5 in synaptic plasticity and memory

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