The Inhibitory Effects of Terminalia catappa L. Extract on the Migration and Invasion of Human Glioblastoma Multiforme Cells

Glioblastoma multiforme (GBM) is one of the most aggressive and common types of brain tumor. Due to its high proliferation ability, a high lethality rate has been observed with this malignant glial tumor. Terminalia catappa L. (T. catappa) is...

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Autores principales:	Hsiao-Hang Chung, Ming-Ju Hsieh, Yih-Shou Hsieh, Pei-Ni Chen, Chung-Po Ko, Nuo-Yi Yu, Chiao-Wen Lin, Shun-Fa Yang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	glioblastoma multiforme invasion migration brain cancer <i>Terminalia catappa</i> L. Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/c8e30690fcbf44b997b89fa986a9fe2d
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spelling	oai:doaj.org-article:c8e30690fcbf44b997b89fa986a9fe2d2021-11-25T18:40:00ZThe Inhibitory Effects of <i>Terminalia catappa</i> L. Extract on the Migration and Invasion of Human Glioblastoma Multiforme Cells10.3390/ph141111831424-8247https://doaj.org/article/c8e30690fcbf44b997b89fa986a9fe2d2021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1183https://doaj.org/toc/1424-8247Glioblastoma multiforme (GBM) is one of the most aggressive and common types of brain tumor. Due to its high proliferation ability, a high lethality rate has been observed with this malignant glial tumor. <i>Terminalia catappa</i> L. (<i>T</i><i>. catappa</i>) is currently known to have anti-inflammatory and anti-carcinogenesis effects. However, few studies have examined the mechanisms of the leaf extracts of <i>T</i><i>. catappa</i> (TCE) on GBM cells. In the current study, we demonstrated that TCE can significantly inhibit the migration and invasion capabilities of GBM cell lines without showing biotoxic effects. Matrix metalloproteinases-2 (MMP-2) activity and protein expression were attenuated by reducing the p38 phosphorylation involved in the mitogen-activated protein kinase (MAPK) pathway. By treating with TCE and/or p38 inhibitor (SB203580), we confirmed that p38 MAPK is involved in the inhibition of cell migration. In conclusion, our results demonstrated that TCE inhibits human GBM cell migration and MMP-2 expression by regulating the p38 pathway. These results reveal that TCE contains potent therapeutic compounds which could be applied for treating GBM brain tumors.Hsiao-Hang ChungMing-Ju HsiehYih-Shou HsiehPei-Ni ChenChung-Po KoNuo-Yi YuChiao-Wen LinShun-Fa YangMDPI AGarticleglioblastoma multiformeinvasionmigrationbrain cancer<i>Terminalia catappa</i> L.MedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1183, p 1183 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	glioblastoma multiforme invasion migration brain cancer <i>Terminalia catappa</i> L. Medicine R Pharmacy and materia medica RS1-441
spellingShingle	glioblastoma multiforme invasion migration brain cancer <i>Terminalia catappa</i> L. Medicine R Pharmacy and materia medica RS1-441 Hsiao-Hang Chung Ming-Ju Hsieh Yih-Shou Hsieh Pei-Ni Chen Chung-Po Ko Nuo-Yi Yu Chiao-Wen Lin Shun-Fa Yang The Inhibitory Effects of <i>Terminalia catappa</i> L. Extract on the Migration and Invasion of Human Glioblastoma Multiforme Cells
description	Glioblastoma multiforme (GBM) is one of the most aggressive and common types of brain tumor. Due to its high proliferation ability, a high lethality rate has been observed with this malignant glial tumor. <i>Terminalia catappa</i> L. (<i>T</i><i>. catappa</i>) is currently known to have anti-inflammatory and anti-carcinogenesis effects. However, few studies have examined the mechanisms of the leaf extracts of <i>T</i><i>. catappa</i> (TCE) on GBM cells. In the current study, we demonstrated that TCE can significantly inhibit the migration and invasion capabilities of GBM cell lines without showing biotoxic effects. Matrix metalloproteinases-2 (MMP-2) activity and protein expression were attenuated by reducing the p38 phosphorylation involved in the mitogen-activated protein kinase (MAPK) pathway. By treating with TCE and/or p38 inhibitor (SB203580), we confirmed that p38 MAPK is involved in the inhibition of cell migration. In conclusion, our results demonstrated that TCE inhibits human GBM cell migration and MMP-2 expression by regulating the p38 pathway. These results reveal that TCE contains potent therapeutic compounds which could be applied for treating GBM brain tumors.
format	article
author	Hsiao-Hang Chung Ming-Ju Hsieh Yih-Shou Hsieh Pei-Ni Chen Chung-Po Ko Nuo-Yi Yu Chiao-Wen Lin Shun-Fa Yang
author_facet	Hsiao-Hang Chung Ming-Ju Hsieh Yih-Shou Hsieh Pei-Ni Chen Chung-Po Ko Nuo-Yi Yu Chiao-Wen Lin Shun-Fa Yang
author_sort	Hsiao-Hang Chung
title	The Inhibitory Effects of <i>Terminalia catappa</i> L. Extract on the Migration and Invasion of Human Glioblastoma Multiforme Cells
title_short	The Inhibitory Effects of <i>Terminalia catappa</i> L. Extract on the Migration and Invasion of Human Glioblastoma Multiforme Cells
title_full	The Inhibitory Effects of <i>Terminalia catappa</i> L. Extract on the Migration and Invasion of Human Glioblastoma Multiforme Cells
title_fullStr	The Inhibitory Effects of <i>Terminalia catappa</i> L. Extract on the Migration and Invasion of Human Glioblastoma Multiforme Cells
title_full_unstemmed	The Inhibitory Effects of <i>Terminalia catappa</i> L. Extract on the Migration and Invasion of Human Glioblastoma Multiforme Cells
title_sort	inhibitory effects of <i>terminalia catappa</i> l. extract on the migration and invasion of human glioblastoma multiforme cells
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c8e30690fcbf44b997b89fa986a9fe2d
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The Inhibitory Effects of <i>Terminalia catappa</i> L. Extract on the Migration and Invasion of Human Glioblastoma Multiforme Cells

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