The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation
The epigenome has been shown to change with age, potentially impacting on ageing-related disease. Here the authors investigate the DNA methylation state of the genomic loci of human tRNA and observe enrichment for age-related DNA hypermethylation at tRNA loci.
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Nature Portfolio
2021
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oai:doaj.org-article:c8e54c6447404d51b6045745ba3e9a132021-12-02T14:35:38ZThe genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation10.1038/s41467-021-22639-62041-1723https://doaj.org/article/c8e54c6447404d51b6045745ba3e9a132021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22639-6https://doaj.org/toc/2041-1723The epigenome has been shown to change with age, potentially impacting on ageing-related disease. Here the authors investigate the DNA methylation state of the genomic loci of human tRNA and observe enrichment for age-related DNA hypermethylation at tRNA loci.Richard J. ActonWei YuanFei GaoYudong XiaEmma BourneEva WozniakJordana BellKaren LillycropJun WangElaine DennisonNicholas C. HarveyCharles A. MeinTim D. SpectorPirro G. HysiCyrus CooperChristopher G. BellNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Richard J. Acton Wei Yuan Fei Gao Yudong Xia Emma Bourne Eva Wozniak Jordana Bell Karen Lillycrop Jun Wang Elaine Dennison Nicholas C. Harvey Charles A. Mein Tim D. Spector Pirro G. Hysi Cyrus Cooper Christopher G. Bell The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation |
| description |
The epigenome has been shown to change with age, potentially impacting on ageing-related disease. Here the authors investigate the DNA methylation state of the genomic loci of human tRNA and observe enrichment for age-related DNA hypermethylation at tRNA loci. |
| format |
article |
| author |
Richard J. Acton Wei Yuan Fei Gao Yudong Xia Emma Bourne Eva Wozniak Jordana Bell Karen Lillycrop Jun Wang Elaine Dennison Nicholas C. Harvey Charles A. Mein Tim D. Spector Pirro G. Hysi Cyrus Cooper Christopher G. Bell |
| author_facet |
Richard J. Acton Wei Yuan Fei Gao Yudong Xia Emma Bourne Eva Wozniak Jordana Bell Karen Lillycrop Jun Wang Elaine Dennison Nicholas C. Harvey Charles A. Mein Tim D. Spector Pirro G. Hysi Cyrus Cooper Christopher G. Bell |
| author_sort |
Richard J. Acton |
| title |
The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation |
| title_short |
The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation |
| title_full |
The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation |
| title_fullStr |
The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation |
| title_full_unstemmed |
The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation |
| title_sort |
genomic loci of specific human trna genes exhibit ageing-related dna hypermethylation |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/c8e54c6447404d51b6045745ba3e9a13 |
| work_keys_str_mv |
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