Chronic Cholecystitis of Dogs: Clinicopathologic Features and Relationship with Liver

(1) Background: Chronic cholecystitis of dogs has not been vigorously investigated histopathologically. In addition, the relationship between gallbladder and liver diseases is not known. (2) Methods: We aimed to provide a hallmark for canine chronic cholecystitis using clinical data, histopathology,...

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Autores principales:	Ikki Mitsui, Shigeaki Ohtsuki, Kazuyuki Uchida
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cholecystitis dog gallbladder histochemistry histopathology immunohistochemistry Veterinary medicine SF600-1100 Zoology QL1-991
Acceso en línea:	https://doaj.org/article/c8e5a55c30e543a0a851c9553ad63e04
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spelling	oai:doaj.org-article:c8e5a55c30e543a0a851c9553ad63e042021-11-25T16:21:33ZChronic Cholecystitis of Dogs: Clinicopathologic Features and Relationship with Liver10.3390/ani111133242076-2615https://doaj.org/article/c8e5a55c30e543a0a851c9553ad63e042021-11-01T00:00:00Zhttps://www.mdpi.com/2076-2615/11/11/3324https://doaj.org/toc/2076-2615(1) Background: Chronic cholecystitis of dogs has not been vigorously investigated histopathologically. In addition, the relationship between gallbladder and liver diseases is not known. (2) Methods: We aimed to provide a hallmark for canine chronic cholecystitis using clinical data, histopathology, histochemistry, immunohistochemistry, and statistical analysis. (3) Results: Our investigation of 219 ultrasonographically abnormal surgically resected canine gallbladders revealed 189 cases (86.3%) of mucosal lymphoplasmacytic infiltration (chronic cholecystitis). Sludge, a gravity-dependent or nondependent fine granular hyperechoic material, was more prevalent (105/219, 47.9%) than mucocele (51/219, 23.2%) in this cohort. Mucosal lymphoid follicles were detected in 68/219 cases (31%), suggesting the influence of long-standing antigenic stimulation. Bacteria were histochemically detected in 41/60 (68.3%) of heavily inflamed gallbladders, 18/129 (14%) of lightly inflamed, and 3/18 (16.7%) of uninflamed gallbladders, suggesting a possible relationship between bacteria and chronic cholecystitis. Simultaneous liver biopsies revealed mild or no inflammation, changes consistent with primary portal vein hypoplasia, and mild hepatocellular degeneration. (4) Conclusions: Based on the results of our statistical analysis, we conclude that canine chronic cholecystitis is a long-standing inflammatory process of unknown (but possibly bacterial) etiology and that liver pathology is unlikely the cause of chronic cholecystitis in dogs.Ikki MitsuiShigeaki OhtsukiKazuyuki UchidaMDPI AGarticlecholecystitisdoggallbladderhistochemistryhistopathologyimmunohistochemistryVeterinary medicineSF600-1100ZoologyQL1-991ENAnimals, Vol 11, Iss 3324, p 3324 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cholecystitis dog gallbladder histochemistry histopathology immunohistochemistry Veterinary medicine SF600-1100 Zoology QL1-991
spellingShingle	cholecystitis dog gallbladder histochemistry histopathology immunohistochemistry Veterinary medicine SF600-1100 Zoology QL1-991 Ikki Mitsui Shigeaki Ohtsuki Kazuyuki Uchida Chronic Cholecystitis of Dogs: Clinicopathologic Features and Relationship with Liver
description	(1) Background: Chronic cholecystitis of dogs has not been vigorously investigated histopathologically. In addition, the relationship between gallbladder and liver diseases is not known. (2) Methods: We aimed to provide a hallmark for canine chronic cholecystitis using clinical data, histopathology, histochemistry, immunohistochemistry, and statistical analysis. (3) Results: Our investigation of 219 ultrasonographically abnormal surgically resected canine gallbladders revealed 189 cases (86.3%) of mucosal lymphoplasmacytic infiltration (chronic cholecystitis). Sludge, a gravity-dependent or nondependent fine granular hyperechoic material, was more prevalent (105/219, 47.9%) than mucocele (51/219, 23.2%) in this cohort. Mucosal lymphoid follicles were detected in 68/219 cases (31%), suggesting the influence of long-standing antigenic stimulation. Bacteria were histochemically detected in 41/60 (68.3%) of heavily inflamed gallbladders, 18/129 (14%) of lightly inflamed, and 3/18 (16.7%) of uninflamed gallbladders, suggesting a possible relationship between bacteria and chronic cholecystitis. Simultaneous liver biopsies revealed mild or no inflammation, changes consistent with primary portal vein hypoplasia, and mild hepatocellular degeneration. (4) Conclusions: Based on the results of our statistical analysis, we conclude that canine chronic cholecystitis is a long-standing inflammatory process of unknown (but possibly bacterial) etiology and that liver pathology is unlikely the cause of chronic cholecystitis in dogs.
format	article
author	Ikki Mitsui Shigeaki Ohtsuki Kazuyuki Uchida
author_facet	Ikki Mitsui Shigeaki Ohtsuki Kazuyuki Uchida
author_sort	Ikki Mitsui
title	Chronic Cholecystitis of Dogs: Clinicopathologic Features and Relationship with Liver
title_short	Chronic Cholecystitis of Dogs: Clinicopathologic Features and Relationship with Liver
title_full	Chronic Cholecystitis of Dogs: Clinicopathologic Features and Relationship with Liver
title_fullStr	Chronic Cholecystitis of Dogs: Clinicopathologic Features and Relationship with Liver
title_full_unstemmed	Chronic Cholecystitis of Dogs: Clinicopathologic Features and Relationship with Liver
title_sort	chronic cholecystitis of dogs: clinicopathologic features and relationship with liver
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c8e5a55c30e543a0a851c9553ad63e04
work_keys_str_mv	AT ikkimitsui chroniccholecystitisofdogsclinicopathologicfeaturesandrelationshipwithliver AT shigeakiohtsuki chroniccholecystitisofdogsclinicopathologicfeaturesandrelationshipwithliver AT kazuyukiuchida chroniccholecystitisofdogsclinicopathologicfeaturesandrelationshipwithliver
_version_	1718413226390061056

Chronic Cholecystitis of Dogs: Clinicopathologic Features and Relationship with Liver

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