Dupilumab side effect in a patient with atopic dermatitis: a case report study
Sakhar S Albader,1 Abdulmajeed A Alharbi,2 Rakan F Alenezi,1 Fahad M Alsaif31College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2College of Medicine, Alqassim University, Qassim, Saudi Arabia; 3Division of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi ArabiaAbst...
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Dove Medical Press
2019
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oai:doaj.org-article:c8e5c67d63544b7c94d0155032748adc2021-12-02T03:37:38ZDupilumab side effect in a patient with atopic dermatitis: a case report study1177-5491https://doaj.org/article/c8e5c67d63544b7c94d0155032748adc2019-05-01T00:00:00Zhttps://www.dovepress.com/dupilumab-side-effect-in-a-patient-with-atopic-dermatitis-a-case-repor-peer-reviewed-article-BTThttps://doaj.org/toc/1177-5491Sakhar S Albader,1 Abdulmajeed A Alharbi,2 Rakan F Alenezi,1 Fahad M Alsaif31College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2College of Medicine, Alqassim University, Qassim, Saudi Arabia; 3Division of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi ArabiaAbstract: Atopic dermatitis (eczema) is a common chronic disease that is described as severe itching associated with recurrent eczematous lesions. In 2017 the US Food and Drug Administration approved dupilumab for treatment of adults with moderate to severe atopic dermatitis not well controlled with topical therapies or when other therapies are inadvisable. Dupilumab is a monoclonal antibody that inhibits interleukin-4 (IL-4) and IL-13 signaling by specifically binding to the IL-4R-alpha subunit shared by the IL-4 and IL-13 receptor complexes. There are many adverse effects reported after dupilumab therapy; commonly reported adverse effects include local injection site reactions, conjunctivitis, headache, and nasopharyngitis. Some adverse effects are rare, eg, alopecia areata and cicatricial extropion. We report a new case of a 28-year-old female who experienced face and neck rash after dupilumab injection.Keywords: atopic dermatitis, dupilumab, eczema, adverse effectAlbader SSAlharbi AAAlenezi RFAlsaif FMDove Medical PressarticleAtopic dermatitisDupilumabMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol Volume 13, Pp 79-82 (2019) |
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Atopic dermatitis Dupilumab Medicine (General) R5-920 Albader SS Alharbi AA Alenezi RF Alsaif FM Dupilumab side effect in a patient with atopic dermatitis: a case report study |
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Sakhar S Albader,1 Abdulmajeed A Alharbi,2 Rakan F Alenezi,1 Fahad M Alsaif31College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2College of Medicine, Alqassim University, Qassim, Saudi Arabia; 3Division of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi ArabiaAbstract: Atopic dermatitis (eczema) is a common chronic disease that is described as severe itching associated with recurrent eczematous lesions. In 2017 the US Food and Drug Administration approved dupilumab for treatment of adults with moderate to severe atopic dermatitis not well controlled with topical therapies or when other therapies are inadvisable. Dupilumab is a monoclonal antibody that inhibits interleukin-4 (IL-4) and IL-13 signaling by specifically binding to the IL-4R-alpha subunit shared by the IL-4 and IL-13 receptor complexes. There are many adverse effects reported after dupilumab therapy; commonly reported adverse effects include local injection site reactions, conjunctivitis, headache, and nasopharyngitis. Some adverse effects are rare, eg, alopecia areata and cicatricial extropion. We report a new case of a 28-year-old female who experienced face and neck rash after dupilumab injection.Keywords: atopic dermatitis, dupilumab, eczema, adverse effect |
format |
article |
author |
Albader SS Alharbi AA Alenezi RF Alsaif FM |
author_facet |
Albader SS Alharbi AA Alenezi RF Alsaif FM |
author_sort |
Albader SS |
title |
Dupilumab side effect in a patient with atopic dermatitis: a case report study |
title_short |
Dupilumab side effect in a patient with atopic dermatitis: a case report study |
title_full |
Dupilumab side effect in a patient with atopic dermatitis: a case report study |
title_fullStr |
Dupilumab side effect in a patient with atopic dermatitis: a case report study |
title_full_unstemmed |
Dupilumab side effect in a patient with atopic dermatitis: a case report study |
title_sort |
dupilumab side effect in a patient with atopic dermatitis: a case report study |
publisher |
Dove Medical Press |
publishDate |
2019 |
url |
https://doaj.org/article/c8e5c67d63544b7c94d0155032748adc |
work_keys_str_mv |
AT albaderss dupilumabsideeffectinapatientwithatopicdermatitisacasereportstudy AT alharbiaa dupilumabsideeffectinapatientwithatopicdermatitisacasereportstudy AT alenezirf dupilumabsideeffectinapatientwithatopicdermatitisacasereportstudy AT alsaiffm dupilumabsideeffectinapatientwithatopicdermatitisacasereportstudy |
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1718401698020458496 |