Challenges in the development of future treatments for breast cancer stem cells

Shyam A Patel1,2, Anicia Ndabahaliye2, Philip K Lim2, Russell Milton2, Pranela Rameshwar21Graduate School of Biomedical Sciences, 2Department of Medicine &ndash; Division of Hematology/Oncology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USAAbs...

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Autores principales:	Shyam A Patel, Anicia Ndabahaliye, Philip K Lim, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/c8e729ff37614d1db2751a90c3a9d95c
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spelling	oai:doaj.org-article:c8e729ff37614d1db2751a90c3a9d95c2021-12-02T05:54:54ZChallenges in the development of future treatments for breast cancer stem cells1179-1314https://doaj.org/article/c8e729ff37614d1db2751a90c3a9d95c2010-03-01T00:00:00Zhttp://www.dovepress.com/challenges-in-the-development-of-future-treatments-for-breast-cancer-s-a4058https://doaj.org/toc/1179-1314Shyam A Patel1,2, Anicia Ndabahaliye2, Philip K Lim2, Russell Milton2, Pranela Rameshwar21Graduate School of Biomedical Sciences, 2Department of Medicine &ndash; Division of Hematology/Oncology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USAAbstract: The recurrence of tumors after years of disease-free survival has spurred interest in the concept that cancers may have a stem cell basis. Current speculation holds that as few as 0.1% of the tumor mass may be chemoresistant and radioresistant, harboring stem-like properties that drive tumor survival, development, and metastasis. There are intense investigations to characterize cancer stem cells on the basis of self-renewal and multi-lineage differentiation. Thus far, no successful targeted therapies have been developed and reached the clinic, but as these cells are isolated and characterized, insights may be unraveled. In this review, we discuss the controversy over the origins of the cancer stem cell hypothesis and the unforeseen factors that may facilitate breast cancer stem cell survival and metastasis. We discuss the role of tumor microenvironment, including carcinoma-associated fibroblasts, epigenetic factors, and the Th1/Th2 balance, in supporting breast cancer stem cells. In addition, we have incorporated ideas on the epithelial-to-mesenchymal transition in metastatic dissemination of epithelial malignancies. This area is relevant since breast cancer stem cells have been suggested to revert to a mesenchymal phenotype during the progression of cancer. Finally we discuss prospects of developing targeted therapy including novel treatment modalities such as oncolytic viral therapy, differentiation therapy, and nanotechnology.Keywords: cancer stem cells, EMT, oncolytic viral therapy, microenvironment, side population, crosstalk Shyam A PatelAnicia NdabahaliyePhilip K Limet alDove Medical PressarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol 2010, Iss default, Pp 1-11 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Shyam A Patel Anicia Ndabahaliye Philip K Lim et al Challenges in the development of future treatments for breast cancer stem cells
description	Shyam A Patel1,2, Anicia Ndabahaliye2, Philip K Lim2, Russell Milton2, Pranela Rameshwar21Graduate School of Biomedical Sciences, 2Department of Medicine &ndash; Division of Hematology/Oncology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USAAbstract: The recurrence of tumors after years of disease-free survival has spurred interest in the concept that cancers may have a stem cell basis. Current speculation holds that as few as 0.1% of the tumor mass may be chemoresistant and radioresistant, harboring stem-like properties that drive tumor survival, development, and metastasis. There are intense investigations to characterize cancer stem cells on the basis of self-renewal and multi-lineage differentiation. Thus far, no successful targeted therapies have been developed and reached the clinic, but as these cells are isolated and characterized, insights may be unraveled. In this review, we discuss the controversy over the origins of the cancer stem cell hypothesis and the unforeseen factors that may facilitate breast cancer stem cell survival and metastasis. We discuss the role of tumor microenvironment, including carcinoma-associated fibroblasts, epigenetic factors, and the Th1/Th2 balance, in supporting breast cancer stem cells. In addition, we have incorporated ideas on the epithelial-to-mesenchymal transition in metastatic dissemination of epithelial malignancies. This area is relevant since breast cancer stem cells have been suggested to revert to a mesenchymal phenotype during the progression of cancer. Finally we discuss prospects of developing targeted therapy including novel treatment modalities such as oncolytic viral therapy, differentiation therapy, and nanotechnology.Keywords: cancer stem cells, EMT, oncolytic viral therapy, microenvironment, side population, crosstalk
format	article
author	Shyam A Patel Anicia Ndabahaliye Philip K Lim et al
author_facet	Shyam A Patel Anicia Ndabahaliye Philip K Lim et al
author_sort	Shyam A Patel
title	Challenges in the development of future treatments for breast cancer stem cells
title_short	Challenges in the development of future treatments for breast cancer stem cells
title_full	Challenges in the development of future treatments for breast cancer stem cells
title_fullStr	Challenges in the development of future treatments for breast cancer stem cells
title_full_unstemmed	Challenges in the development of future treatments for breast cancer stem cells
title_sort	challenges in the development of future treatments for breast cancer stem cells
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/c8e729ff37614d1db2751a90c3a9d95c
work_keys_str_mv	AT shyamapatel challengesinthedevelopmentoffuturetreatmentsforbreastcancerstemcells AT aniciandabahaliye challengesinthedevelopmentoffuturetreatmentsforbreastcancerstemcells AT philipklim challengesinthedevelopmentoffuturetreatmentsforbreastcancerstemcells AT etal challengesinthedevelopmentoffuturetreatmentsforbreastcancerstemcells
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Challenges in the development of future treatments for breast cancer stem cells

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