Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy
Mutations in the LaminA gene are the second most common inherited cause of Dilated Cardiomyopathy, a major form of heart failure. Here the authors show that disruption of the nuclear protein SUN1 in cardiomyocytes, by AAV mediated transduction of a SUN1 inhibitor, significantly suppress cardiomyopat...
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Nature Portfolio
2021
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oai:doaj.org-article:c8e8b6f93e7b442686a2d1ede70d73992021-12-02T16:35:46ZDisrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy10.1038/s41467-021-24849-42041-1723https://doaj.org/article/c8e8b6f93e7b442686a2d1ede70d73992021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24849-4https://doaj.org/toc/2041-1723Mutations in the LaminA gene are the second most common inherited cause of Dilated Cardiomyopathy, a major form of heart failure. Here the authors show that disruption of the nuclear protein SUN1 in cardiomyocytes, by AAV mediated transduction of a SUN1 inhibitor, significantly suppress cardiomyopathy progression, providing a potential therapeutic route to treat this disease.Ruth Jinfen ChaiHendrikje WernerPeter Yiqing LiYin Loon LeeKhaing Thet NyeinIrina SoloveiTuan Danh Anh LuuBhavya SharmaRaju NavasankariMartina MaricLois Yu En SimYing Jie LohEdita AliwargaJason Wen Long CheongAlexandre ChojnowskiMatias Ilmari AutioYu HaiyangKenneth Kian Boon TanChoong Tat KengShi Ling NgWei Leong ChewMichael FerencziBrian BurkeRoger Sik Yin FooColin L. StewartNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
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Science Q Ruth Jinfen Chai Hendrikje Werner Peter Yiqing Li Yin Loon Lee Khaing Thet Nyein Irina Solovei Tuan Danh Anh Luu Bhavya Sharma Raju Navasankari Martina Maric Lois Yu En Sim Ying Jie Loh Edita Aliwarga Jason Wen Long Cheong Alexandre Chojnowski Matias Ilmari Autio Yu Haiyang Kenneth Kian Boon Tan Choong Tat Keng Shi Ling Ng Wei Leong Chew Michael Ferenczi Brian Burke Roger Sik Yin Foo Colin L. Stewart Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy |
| description |
Mutations in the LaminA gene are the second most common inherited cause of Dilated Cardiomyopathy, a major form of heart failure. Here the authors show that disruption of the nuclear protein SUN1 in cardiomyocytes, by AAV mediated transduction of a SUN1 inhibitor, significantly suppress cardiomyopathy progression, providing a potential therapeutic route to treat this disease. |
| format |
article |
| author |
Ruth Jinfen Chai Hendrikje Werner Peter Yiqing Li Yin Loon Lee Khaing Thet Nyein Irina Solovei Tuan Danh Anh Luu Bhavya Sharma Raju Navasankari Martina Maric Lois Yu En Sim Ying Jie Loh Edita Aliwarga Jason Wen Long Cheong Alexandre Chojnowski Matias Ilmari Autio Yu Haiyang Kenneth Kian Boon Tan Choong Tat Keng Shi Ling Ng Wei Leong Chew Michael Ferenczi Brian Burke Roger Sik Yin Foo Colin L. Stewart |
| author_facet |
Ruth Jinfen Chai Hendrikje Werner Peter Yiqing Li Yin Loon Lee Khaing Thet Nyein Irina Solovei Tuan Danh Anh Luu Bhavya Sharma Raju Navasankari Martina Maric Lois Yu En Sim Ying Jie Loh Edita Aliwarga Jason Wen Long Cheong Alexandre Chojnowski Matias Ilmari Autio Yu Haiyang Kenneth Kian Boon Tan Choong Tat Keng Shi Ling Ng Wei Leong Chew Michael Ferenczi Brian Burke Roger Sik Yin Foo Colin L. Stewart |
| author_sort |
Ruth Jinfen Chai |
| title |
Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy |
| title_short |
Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy |
| title_full |
Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy |
| title_fullStr |
Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy |
| title_full_unstemmed |
Disrupting the LINC complex by AAV mediated gene transduction prevents progression of Lamin induced cardiomyopathy |
| title_sort |
disrupting the linc complex by aav mediated gene transduction prevents progression of lamin induced cardiomyopathy |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/c8e8b6f93e7b442686a2d1ede70d7399 |
| work_keys_str_mv |
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