Cellular Technologies in Traumatology: From Cells to Tissue Engineering

Injuries and degenerative changes of tendons are common damages of the musculoskeletal system. Due to its hypovascular character the tendon has a limited natural ability to recover. For typical surgical treatment, the tendon integrity is restored, but in most cases, there occurs formation of the con...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	N. N. Dremina, I. S. Trukhan, I. A. Shurygina
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2021
Materias:	сell technologies mesenchymal stem cells reparation traumatology tendon 3d-bioprinting Science Q
Acceso en línea:	https://doaj.org/article/c8e8ec9c01964e82b691e87334b5c37c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c8e8ec9c01964e82b691e87334b5c37c
record_format	dspace
spelling	oai:doaj.org-article:c8e8ec9c01964e82b691e87334b5c37c2021-11-23T06:14:46ZCellular Technologies in Traumatology: From Cells to Tissue Engineering2541-94202587-959610.29413/ABS.2021-6.2.19https://doaj.org/article/c8e8ec9c01964e82b691e87334b5c37c2021-06-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2748https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Injuries and degenerative changes of tendons are common damages of the musculoskeletal system. Due to its hypovascular character the tendon has a limited natural ability to recover. For typical surgical treatment, the tendon integrity is restored, but in most cases, there occurs formation of the connective tissue scar resulting in structural and mechanical functionality disruption. The insufficient effectiveness of traditional therapy methods requires the search for alternative ways to restore damaged tendon tissues. This article discusses new effective methods for improving the treatment that base on the use of cellular technologies among which one of the main directions is mesenchymal stem cell application. Due to mesenchymal stem cells, there is a shift from pro-fibrotic and pro-inflammatory reactions of cells to pro-regenerative ones. Stem cells being multipotent and having among other things tenogenic potential are considered a promising material for repairing damaged tendons. The article also describes the sources of progenitor tendon cells including the tendon bundles and pericytes the main markers of which are Scx and Mkx that are proteins of the transcription factor superfamily, and Tnmd that is transmembrane glycoprotein.The growth factors that not only enhance the proliferative activity of mesenchymal stem cells but also promote in vitro tenogenic genes expression as well as the collagen Itype production what is necessary for tendon formation are considered. Along with growth factors, the morphogenetic protein BMP14 is presented, this protein increases themesenchymal stem cell proliferation and contributes directed tenogenic differentiation of these cells, suppressing their adipogenic and chondrogenic potentials.In recent years, mesenchymal stem cells have been used both separately and in combination with various growth factors and different three-dimensional structures providing the interaction with all of the cell types.The issues of the latest 3D-bioprinting technology allowing to make tissue-like structures for replacement damaged tissues and organs are discussed. 3D-bioprinting technology is known to allow acting exact spatio-temporal control of the distribution of cells, growth factors, small molecules, drugs and biologically active substances.N. N. DreminaI. S. TrukhanI. A. ShuryginaScientific Сentre for Family Health and Human Reproduction Problemsarticleсell technologiesmesenchymal stem cellsreparationtraumatologytendon3d-bioprintingScienceQRUActa Biomedica Scientifica, Vol 6, Iss 2, Pp 166-175 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	сell technologies mesenchymal stem cells reparation traumatology tendon 3d-bioprinting Science Q
spellingShingle	сell technologies mesenchymal stem cells reparation traumatology tendon 3d-bioprinting Science Q N. N. Dremina I. S. Trukhan I. A. Shurygina Cellular Technologies in Traumatology: From Cells to Tissue Engineering
description	Injuries and degenerative changes of tendons are common damages of the musculoskeletal system. Due to its hypovascular character the tendon has a limited natural ability to recover. For typical surgical treatment, the tendon integrity is restored, but in most cases, there occurs formation of the connective tissue scar resulting in structural and mechanical functionality disruption. The insufficient effectiveness of traditional therapy methods requires the search for alternative ways to restore damaged tendon tissues. This article discusses new effective methods for improving the treatment that base on the use of cellular technologies among which one of the main directions is mesenchymal stem cell application. Due to mesenchymal stem cells, there is a shift from pro-fibrotic and pro-inflammatory reactions of cells to pro-regenerative ones. Stem cells being multipotent and having among other things tenogenic potential are considered a promising material for repairing damaged tendons. The article also describes the sources of progenitor tendon cells including the tendon bundles and pericytes the main markers of which are Scx and Mkx that are proteins of the transcription factor superfamily, and Tnmd that is transmembrane glycoprotein.The growth factors that not only enhance the proliferative activity of mesenchymal stem cells but also promote in vitro tenogenic genes expression as well as the collagen Itype production what is necessary for tendon formation are considered. Along with growth factors, the morphogenetic protein BMP14 is presented, this protein increases themesenchymal stem cell proliferation and contributes directed tenogenic differentiation of these cells, suppressing their adipogenic and chondrogenic potentials.In recent years, mesenchymal stem cells have been used both separately and in combination with various growth factors and different three-dimensional structures providing the interaction with all of the cell types.The issues of the latest 3D-bioprinting technology allowing to make tissue-like structures for replacement damaged tissues and organs are discussed. 3D-bioprinting technology is known to allow acting exact spatio-temporal control of the distribution of cells, growth factors, small molecules, drugs and biologically active substances.
format	article
author	N. N. Dremina I. S. Trukhan I. A. Shurygina
author_facet	N. N. Dremina I. S. Trukhan I. A. Shurygina
author_sort	N. N. Dremina
title	Cellular Technologies in Traumatology: From Cells to Tissue Engineering
title_short	Cellular Technologies in Traumatology: From Cells to Tissue Engineering
title_full	Cellular Technologies in Traumatology: From Cells to Tissue Engineering
title_fullStr	Cellular Technologies in Traumatology: From Cells to Tissue Engineering
title_full_unstemmed	Cellular Technologies in Traumatology: From Cells to Tissue Engineering
title_sort	cellular technologies in traumatology: from cells to tissue engineering
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2021
url	https://doaj.org/article/c8e8ec9c01964e82b691e87334b5c37c
work_keys_str_mv	AT nndremina cellulartechnologiesintraumatologyfromcellstotissueengineering AT istrukhan cellulartechnologiesintraumatologyfromcellstotissueengineering AT iashurygina cellulartechnologiesintraumatologyfromcellstotissueengineering
_version_	1718416909059227648

Cellular Technologies in Traumatology: From Cells to Tissue Engineering

Ejemplares similares