circRNAs: Insight Into Their Role in Tumor-Associated Macrophages

Currently, it is well known that the tumor microenvironment not only provides energy support for tumor growth but also regulates tumor signaling pathways and promotes the proliferation, invasion, metastasis, and drug resistance of tumor cells. The tumor microenvironment, especially the function and...

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Autores principales:	Saili Duan, Shan Wang, Tao Huang, Junpu Wang, Xiaoqing Yuan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	circRNA TAMs M2 macrophage polarization cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/c8ed8bd9cf374629803124f15e83f6ad
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spelling	oai:doaj.org-article:c8ed8bd9cf374629803124f15e83f6ad2021-12-01T22:43:38ZcircRNAs: Insight Into Their Role in Tumor-Associated Macrophages2234-943X10.3389/fonc.2021.780744https://doaj.org/article/c8ed8bd9cf374629803124f15e83f6ad2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.780744/fullhttps://doaj.org/toc/2234-943XCurrently, it is well known that the tumor microenvironment not only provides energy support for tumor growth but also regulates tumor signaling pathways and promotes the proliferation, invasion, metastasis, and drug resistance of tumor cells. The tumor microenvironment, especially the function and mechanism of tumor-associated macrophages (TAMs), has attracted great attention. TAMs are the most common immune cells in the tumor microenvironment and play a vital role in the occurrence and development of tumors. circular RNA (circRNA) is a unique, widespread, and stable form of non-coding RNA (ncRNA), but little is known about the role of circRNAs in TAMs or how TAMs affect circRNAs. In this review, we summarize the specific manifestations of circRNAs that affect the tumor-associated macrophages and play a significant role in tumor progression. This review helps improve our understanding of the association between circRNAs and TAMs, thereby promoting the development and progress of potential clinical targeted therapies.Saili DuanSaili DuanSaili DuanSaili DuanShan WangShan WangShan WangShan WangTao HuangTao HuangTao HuangTao HuangJunpu WangJunpu WangJunpu WangJunpu WangXiaoqing YuanXiaoqing YuanFrontiers Media S.A.articlecircRNATAMsM2 macrophagepolarizationcancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	circRNA TAMs M2 macrophage polarization cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	circRNA TAMs M2 macrophage polarization cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Saili Duan Saili Duan Saili Duan Saili Duan Shan Wang Shan Wang Shan Wang Shan Wang Tao Huang Tao Huang Tao Huang Tao Huang Junpu Wang Junpu Wang Junpu Wang Junpu Wang Xiaoqing Yuan Xiaoqing Yuan circRNAs: Insight Into Their Role in Tumor-Associated Macrophages
description	Currently, it is well known that the tumor microenvironment not only provides energy support for tumor growth but also regulates tumor signaling pathways and promotes the proliferation, invasion, metastasis, and drug resistance of tumor cells. The tumor microenvironment, especially the function and mechanism of tumor-associated macrophages (TAMs), has attracted great attention. TAMs are the most common immune cells in the tumor microenvironment and play a vital role in the occurrence and development of tumors. circular RNA (circRNA) is a unique, widespread, and stable form of non-coding RNA (ncRNA), but little is known about the role of circRNAs in TAMs or how TAMs affect circRNAs. In this review, we summarize the specific manifestations of circRNAs that affect the tumor-associated macrophages and play a significant role in tumor progression. This review helps improve our understanding of the association between circRNAs and TAMs, thereby promoting the development and progress of potential clinical targeted therapies.
format	article
author	Saili Duan Saili Duan Saili Duan Saili Duan Shan Wang Shan Wang Shan Wang Shan Wang Tao Huang Tao Huang Tao Huang Tao Huang Junpu Wang Junpu Wang Junpu Wang Junpu Wang Xiaoqing Yuan Xiaoqing Yuan
author_facet	Saili Duan Saili Duan Saili Duan Saili Duan Shan Wang Shan Wang Shan Wang Shan Wang Tao Huang Tao Huang Tao Huang Tao Huang Junpu Wang Junpu Wang Junpu Wang Junpu Wang Xiaoqing Yuan Xiaoqing Yuan
author_sort	Saili Duan
title	circRNAs: Insight Into Their Role in Tumor-Associated Macrophages
title_short	circRNAs: Insight Into Their Role in Tumor-Associated Macrophages
title_full	circRNAs: Insight Into Their Role in Tumor-Associated Macrophages
title_fullStr	circRNAs: Insight Into Their Role in Tumor-Associated Macrophages
title_full_unstemmed	circRNAs: Insight Into Their Role in Tumor-Associated Macrophages
title_sort	circrnas: insight into their role in tumor-associated macrophages
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c8ed8bd9cf374629803124f15e83f6ad
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circRNAs: Insight Into Their Role in Tumor-Associated Macrophages

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