A review of electroencephalographic changes in diabetes mellitus in relation to major depressive disorder

Anusha Baskaran,1,2 Roumen Milev,3 Roger S McIntyre21Centre for Neuroscience Studies, Queen&#39;s University, Kingston; 2Mood Disorders Psychopharmacology Unit, University Health Network, Toronto; 3Department of Psychiatry, Queen&#39;s University, Kingston, CanadaAbstract: A bidirect...

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Autores principales:	Baskaran A, Milev R, McIntyre RS
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/c8ee6d634871422baa27e116390417dd
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spelling	oai:doaj.org-article:c8ee6d634871422baa27e116390417dd2021-12-02T00:30:20ZA review of electroencephalographic changes in diabetes mellitus in relation to major depressive disorder1176-63281178-2021https://doaj.org/article/c8ee6d634871422baa27e116390417dd2013-01-01T00:00:00Zhttp://www.dovepress.com/a-review-of-electroencephalographic-changes-in-diabetes-mellitus-in-re-a11979https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Anusha Baskaran,1,2 Roumen Milev,3 Roger S McIntyre21Centre for Neuroscience Studies, Queen&#39;s University, Kingston; 2Mood Disorders Psychopharmacology Unit, University Health Network, Toronto; 3Department of Psychiatry, Queen&#39;s University, Kingston, CanadaAbstract: A bidirectional relationship exists between diabetes mellitus (DM) and major depressive disorder (MDD), with depression commonly reported in both type 1 DM (T1DM) and type 2 DM (T2DM), and depressive symptoms associated with a higher incidence of diabetes. However, how the two conditions are pathologically connected is not completely understood. Similar neurophysiological abnormalities have been reported in both DM and MDD, including elevated electroencephalographic (EEG) activity in low-frequency slow waves and increased latency and/or reduced amplitude of event-related potentials. It is possible that this association reflects some common underlying pathology, and it has been proposed that diabetes may place patients at risk for depression through a biological mechanism linking the metabolic changes of DM to changes in the central nervous system. In this review we will discuss EEG abnormalities in DM, as well as the biological mechanisms underlying various EEG parameters, in order to evaluate whether or not a common EEG biosignature exists between DM and MDD. Identifying such commonalities could significantly inform the current understanding of the mechanisms that subserve the development of the two conditions. Moreover, this new insight may provide the basis for informing new drug discovery capable of mitigating and possibly even preventing both conditions.Keywords: electroencephalography, event-related potential, diabetes mellitus, major depressive disorderBaskaran AMilev RMcIntyre RSDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2013, Iss default, Pp 143-150 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Baskaran A Milev R McIntyre RS A review of electroencephalographic changes in diabetes mellitus in relation to major depressive disorder
description	Anusha Baskaran,1,2 Roumen Milev,3 Roger S McIntyre21Centre for Neuroscience Studies, Queen&#39;s University, Kingston; 2Mood Disorders Psychopharmacology Unit, University Health Network, Toronto; 3Department of Psychiatry, Queen&#39;s University, Kingston, CanadaAbstract: A bidirectional relationship exists between diabetes mellitus (DM) and major depressive disorder (MDD), with depression commonly reported in both type 1 DM (T1DM) and type 2 DM (T2DM), and depressive symptoms associated with a higher incidence of diabetes. However, how the two conditions are pathologically connected is not completely understood. Similar neurophysiological abnormalities have been reported in both DM and MDD, including elevated electroencephalographic (EEG) activity in low-frequency slow waves and increased latency and/or reduced amplitude of event-related potentials. It is possible that this association reflects some common underlying pathology, and it has been proposed that diabetes may place patients at risk for depression through a biological mechanism linking the metabolic changes of DM to changes in the central nervous system. In this review we will discuss EEG abnormalities in DM, as well as the biological mechanisms underlying various EEG parameters, in order to evaluate whether or not a common EEG biosignature exists between DM and MDD. Identifying such commonalities could significantly inform the current understanding of the mechanisms that subserve the development of the two conditions. Moreover, this new insight may provide the basis for informing new drug discovery capable of mitigating and possibly even preventing both conditions.Keywords: electroencephalography, event-related potential, diabetes mellitus, major depressive disorder
format	article
author	Baskaran A Milev R McIntyre RS
author_facet	Baskaran A Milev R McIntyre RS
author_sort	Baskaran A
title	A review of electroencephalographic changes in diabetes mellitus in relation to major depressive disorder
title_short	A review of electroencephalographic changes in diabetes mellitus in relation to major depressive disorder
title_full	A review of electroencephalographic changes in diabetes mellitus in relation to major depressive disorder
title_fullStr	A review of electroencephalographic changes in diabetes mellitus in relation to major depressive disorder
title_full_unstemmed	A review of electroencephalographic changes in diabetes mellitus in relation to major depressive disorder
title_sort	review of electroencephalographic changes in diabetes mellitus in relation to major depressive disorder
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/c8ee6d634871422baa27e116390417dd
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A review of electroencephalographic changes in diabetes mellitus in relation to major depressive disorder

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