Delivery of nanovaccine towards lymphoid organs: recent strategies in enhancing cancer immunotherapy

Abstract With the in-depth exploration on cancer therapeutic nanovaccines, increasing evidence shows that the poor delivery of nanovaccines to lymphoid organs has become the culprit limiting the rapid induction of anti-tumor immune response. Unlike the conventional prophylactic vaccines that mainly...

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Autores principales:	Ting Cai, Huina Liu, Shun Zhang, Jing Hu, Lingxiao Zhang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Nanovaccine Cancer immunotherapy Lymphoid organ Vaccine delivery Immune barrier Biotechnology TP248.13-248.65 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/c8efa55ab0ae4d62b5de991db51d14d5
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spelling	oai:doaj.org-article:c8efa55ab0ae4d62b5de991db51d14d52021-11-28T12:26:37ZDelivery of nanovaccine towards lymphoid organs: recent strategies in enhancing cancer immunotherapy10.1186/s12951-021-01146-21477-3155https://doaj.org/article/c8efa55ab0ae4d62b5de991db51d14d52021-11-01T00:00:00Zhttps://doi.org/10.1186/s12951-021-01146-2https://doaj.org/toc/1477-3155Abstract With the in-depth exploration on cancer therapeutic nanovaccines, increasing evidence shows that the poor delivery of nanovaccines to lymphoid organs has become the culprit limiting the rapid induction of anti-tumor immune response. Unlike the conventional prophylactic vaccines that mainly form a depot at the injection site to gradually trigger durable immune response, the rapid proliferation of tumors requires an efficient delivery of nanovaccines to lymphoid organs for rapid induction of anti-tumor immunity. Optimization of the physicochemical properties of nanovaccine (e.g., size, shape, charge, colloidal stability and surface ligands) is an effective strategy to enhance their accumulation in lymphoid organs, and nanovaccines with dynamic structures are also designed for precise targeted delivery of lymphoid organs or their subregions. The recent progress of these nanovaccine delivery strategies is highlighted in this review, and the challenges and future direction are also discussed. Graphical AbstractTing CaiHuina LiuShun ZhangJing HuLingxiao ZhangBMCarticleNanovaccineCancer immunotherapyLymphoid organVaccine deliveryImmune barrierBiotechnologyTP248.13-248.65Medical technologyR855-855.5ENJournal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-23 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nanovaccine Cancer immunotherapy Lymphoid organ Vaccine delivery Immune barrier Biotechnology TP248.13-248.65 Medical technology R855-855.5
spellingShingle	Nanovaccine Cancer immunotherapy Lymphoid organ Vaccine delivery Immune barrier Biotechnology TP248.13-248.65 Medical technology R855-855.5 Ting Cai Huina Liu Shun Zhang Jing Hu Lingxiao Zhang Delivery of nanovaccine towards lymphoid organs: recent strategies in enhancing cancer immunotherapy
description	Abstract With the in-depth exploration on cancer therapeutic nanovaccines, increasing evidence shows that the poor delivery of nanovaccines to lymphoid organs has become the culprit limiting the rapid induction of anti-tumor immune response. Unlike the conventional prophylactic vaccines that mainly form a depot at the injection site to gradually trigger durable immune response, the rapid proliferation of tumors requires an efficient delivery of nanovaccines to lymphoid organs for rapid induction of anti-tumor immunity. Optimization of the physicochemical properties of nanovaccine (e.g., size, shape, charge, colloidal stability and surface ligands) is an effective strategy to enhance their accumulation in lymphoid organs, and nanovaccines with dynamic structures are also designed for precise targeted delivery of lymphoid organs or their subregions. The recent progress of these nanovaccine delivery strategies is highlighted in this review, and the challenges and future direction are also discussed. Graphical Abstract
format	article
author	Ting Cai Huina Liu Shun Zhang Jing Hu Lingxiao Zhang
author_facet	Ting Cai Huina Liu Shun Zhang Jing Hu Lingxiao Zhang
author_sort	Ting Cai
title	Delivery of nanovaccine towards lymphoid organs: recent strategies in enhancing cancer immunotherapy
title_short	Delivery of nanovaccine towards lymphoid organs: recent strategies in enhancing cancer immunotherapy
title_full	Delivery of nanovaccine towards lymphoid organs: recent strategies in enhancing cancer immunotherapy
title_fullStr	Delivery of nanovaccine towards lymphoid organs: recent strategies in enhancing cancer immunotherapy
title_full_unstemmed	Delivery of nanovaccine towards lymphoid organs: recent strategies in enhancing cancer immunotherapy
title_sort	delivery of nanovaccine towards lymphoid organs: recent strategies in enhancing cancer immunotherapy
publisher	BMC
publishDate	2021
url	https://doaj.org/article/c8efa55ab0ae4d62b5de991db51d14d5
work_keys_str_mv	AT tingcai deliveryofnanovaccinetowardslymphoidorgansrecentstrategiesinenhancingcancerimmunotherapy AT huinaliu deliveryofnanovaccinetowardslymphoidorgansrecentstrategiesinenhancingcancerimmunotherapy AT shunzhang deliveryofnanovaccinetowardslymphoidorgansrecentstrategiesinenhancingcancerimmunotherapy AT jinghu deliveryofnanovaccinetowardslymphoidorgansrecentstrategiesinenhancingcancerimmunotherapy AT lingxiaozhang deliveryofnanovaccinetowardslymphoidorgansrecentstrategiesinenhancingcancerimmunotherapy
_version_	1718407982914469888

Delivery of nanovaccine towards lymphoid organs: recent strategies in enhancing cancer immunotherapy

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