Structure of a microtubule-bound axonemal dynein

Axonemal dyneins are tethered to doublet microtubules inside cilia to drive ciliary beating but the mechanisms regulating their localization and function are poorly understood. Here authors report a cryo-EM reconstruction of a three-headed axonemal dynein natively bound to doublet microtubules isola...

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Auteurs principaux:	Travis Walton, Hao Wu, Alan Brown
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/c8f0e725f7d34977b36bcc30f9e5ff76
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spelling	oai:doaj.org-article:c8f0e725f7d34977b36bcc30f9e5ff762021-12-02T14:19:11ZStructure of a microtubule-bound axonemal dynein10.1038/s41467-020-20735-72041-1723https://doaj.org/article/c8f0e725f7d34977b36bcc30f9e5ff762021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20735-7https://doaj.org/toc/2041-1723Axonemal dyneins are tethered to doublet microtubules inside cilia to drive ciliary beating but the mechanisms regulating their localization and function are poorly understood. Here authors report a cryo-EM reconstruction of a three-headed axonemal dynein natively bound to doublet microtubules isolated from cilia which provides a framework to understand the roles of individual subunits.Travis WaltonHao WuAlan BrownNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Travis Walton Hao Wu Alan Brown Structure of a microtubule-bound axonemal dynein
description	Axonemal dyneins are tethered to doublet microtubules inside cilia to drive ciliary beating but the mechanisms regulating their localization and function are poorly understood. Here authors report a cryo-EM reconstruction of a three-headed axonemal dynein natively bound to doublet microtubules isolated from cilia which provides a framework to understand the roles of individual subunits.
format	article
author	Travis Walton Hao Wu Alan Brown
author_facet	Travis Walton Hao Wu Alan Brown
author_sort	Travis Walton
title	Structure of a microtubule-bound axonemal dynein
title_short	Structure of a microtubule-bound axonemal dynein
title_full	Structure of a microtubule-bound axonemal dynein
title_fullStr	Structure of a microtubule-bound axonemal dynein
title_full_unstemmed	Structure of a microtubule-bound axonemal dynein
title_sort	structure of a microtubule-bound axonemal dynein
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c8f0e725f7d34977b36bcc30f9e5ff76
work_keys_str_mv	AT traviswalton structureofamicrotubuleboundaxonemaldynein AT haowu structureofamicrotubuleboundaxonemaldynein AT alanbrown structureofamicrotubuleboundaxonemaldynein
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Structure of a microtubule-bound axonemal dynein

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