Cross-species transmission of a novel adenovirus associated with a fulminant pneumonia outbreak in a new world monkey colony.

Adenoviruses are DNA viruses that naturally infect many vertebrates, including humans and monkeys, and cause a wide range of clinical illnesses in humans. Infection from individual strains has conventionally been thought to be species-specific. Here we applied the Virochip, a pan-viral microarray, t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Eunice C Chen, Shigeo Yagi, Kristi R Kelly, Sally P Mendoza, Ross P Tarara, Don R Canfield, Nicole Maninger, Ann Rosenthal, Abigail Spinner, Karen L Bales, David P Schnurr, Nicholas W Lerche, Charles Y Chiu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/c8f332a913d64a16953f2aa09afd2d62
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c8f332a913d64a16953f2aa09afd2d62
record_format	dspace
spelling	oai:doaj.org-article:c8f332a913d64a16953f2aa09afd2d622021-11-18T06:03:12ZCross-species transmission of a novel adenovirus associated with a fulminant pneumonia outbreak in a new world monkey colony.1553-73661553-737410.1371/journal.ppat.1002155https://doaj.org/article/c8f332a913d64a16953f2aa09afd2d622011-07-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21779173/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Adenoviruses are DNA viruses that naturally infect many vertebrates, including humans and monkeys, and cause a wide range of clinical illnesses in humans. Infection from individual strains has conventionally been thought to be species-specific. Here we applied the Virochip, a pan-viral microarray, to identify a novel adenovirus (TMAdV, titi monkey adenovirus) as the cause of a deadly outbreak in a closed colony of New World monkeys (titi monkeys; Callicebus cupreus) at the California National Primate Research Center (CNPRC). Among 65 titi monkeys housed in a building, 23 (34%) developed upper respiratory symptoms that progressed to fulminant pneumonia and hepatitis, and 19 of 23 monkeys, or 83% of those infected, died or were humanely euthanized. Whole-genome sequencing of TMAdV revealed that this adenovirus is a new species and highly divergent, sharing <57% pairwise nucleotide identity with other adenoviruses. Cultivation of TMAdV was successful in a human A549 lung adenocarcinoma cell line, but not in primary or established monkey kidney cells. At the onset of the outbreak, the researcher in closest contact with the monkeys developed an acute respiratory illness, with symptoms persisting for 4 weeks, and had a convalescent serum sample seropositive for TMAdV. A clinically ill family member, despite having no contact with the CNPRC, also tested positive, and screening of a set of 81 random adult blood donors from the Western United States detected TMAdV-specific neutralizing antibodies in 2 individuals (2/81, or 2.5%). These findings raise the possibility of zoonotic infection by TMAdV and human-to-human transmission of the virus in the population. Given the unusually high case fatality rate from the outbreak (83%), it is unlikely that titi monkeys are the native host species for TMAdV, and the natural reservoir of the virus is still unknown. The discovery of TMAdV, a novel adenovirus with the capacity to infect both monkeys and humans, suggests that adenoviruses should be monitored closely as potential causes of cross-species outbreaks.Eunice C ChenShigeo YagiKristi R KellySally P MendozaRoss P TararaDon R CanfieldNicole ManingerAnn RosenthalAbigail SpinnerKaren L BalesDavid P SchnurrNicholas W LercheCharles Y ChiuPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 7, Iss 7, p e1002155 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Eunice C Chen Shigeo Yagi Kristi R Kelly Sally P Mendoza Ross P Tarara Don R Canfield Nicole Maninger Ann Rosenthal Abigail Spinner Karen L Bales David P Schnurr Nicholas W Lerche Charles Y Chiu Cross-species transmission of a novel adenovirus associated with a fulminant pneumonia outbreak in a new world monkey colony.
description	Adenoviruses are DNA viruses that naturally infect many vertebrates, including humans and monkeys, and cause a wide range of clinical illnesses in humans. Infection from individual strains has conventionally been thought to be species-specific. Here we applied the Virochip, a pan-viral microarray, to identify a novel adenovirus (TMAdV, titi monkey adenovirus) as the cause of a deadly outbreak in a closed colony of New World monkeys (titi monkeys; Callicebus cupreus) at the California National Primate Research Center (CNPRC). Among 65 titi monkeys housed in a building, 23 (34%) developed upper respiratory symptoms that progressed to fulminant pneumonia and hepatitis, and 19 of 23 monkeys, or 83% of those infected, died or were humanely euthanized. Whole-genome sequencing of TMAdV revealed that this adenovirus is a new species and highly divergent, sharing <57% pairwise nucleotide identity with other adenoviruses. Cultivation of TMAdV was successful in a human A549 lung adenocarcinoma cell line, but not in primary or established monkey kidney cells. At the onset of the outbreak, the researcher in closest contact with the monkeys developed an acute respiratory illness, with symptoms persisting for 4 weeks, and had a convalescent serum sample seropositive for TMAdV. A clinically ill family member, despite having no contact with the CNPRC, also tested positive, and screening of a set of 81 random adult blood donors from the Western United States detected TMAdV-specific neutralizing antibodies in 2 individuals (2/81, or 2.5%). These findings raise the possibility of zoonotic infection by TMAdV and human-to-human transmission of the virus in the population. Given the unusually high case fatality rate from the outbreak (83%), it is unlikely that titi monkeys are the native host species for TMAdV, and the natural reservoir of the virus is still unknown. The discovery of TMAdV, a novel adenovirus with the capacity to infect both monkeys and humans, suggests that adenoviruses should be monitored closely as potential causes of cross-species outbreaks.
format	article
author	Eunice C Chen Shigeo Yagi Kristi R Kelly Sally P Mendoza Ross P Tarara Don R Canfield Nicole Maninger Ann Rosenthal Abigail Spinner Karen L Bales David P Schnurr Nicholas W Lerche Charles Y Chiu
author_facet	Eunice C Chen Shigeo Yagi Kristi R Kelly Sally P Mendoza Ross P Tarara Don R Canfield Nicole Maninger Ann Rosenthal Abigail Spinner Karen L Bales David P Schnurr Nicholas W Lerche Charles Y Chiu
author_sort	Eunice C Chen
title	Cross-species transmission of a novel adenovirus associated with a fulminant pneumonia outbreak in a new world monkey colony.
title_short	Cross-species transmission of a novel adenovirus associated with a fulminant pneumonia outbreak in a new world monkey colony.
title_full	Cross-species transmission of a novel adenovirus associated with a fulminant pneumonia outbreak in a new world monkey colony.
title_fullStr	Cross-species transmission of a novel adenovirus associated with a fulminant pneumonia outbreak in a new world monkey colony.
title_full_unstemmed	Cross-species transmission of a novel adenovirus associated with a fulminant pneumonia outbreak in a new world monkey colony.
title_sort	cross-species transmission of a novel adenovirus associated with a fulminant pneumonia outbreak in a new world monkey colony.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/c8f332a913d64a16953f2aa09afd2d62
work_keys_str_mv	AT eunicecchen crossspeciestransmissionofanoveladenovirusassociatedwithafulminantpneumoniaoutbreakinanewworldmonkeycolony AT shigeoyagi crossspeciestransmissionofanoveladenovirusassociatedwithafulminantpneumoniaoutbreakinanewworldmonkeycolony AT kristirkelly crossspeciestransmissionofanoveladenovirusassociatedwithafulminantpneumoniaoutbreakinanewworldmonkeycolony AT sallypmendoza crossspeciestransmissionofanoveladenovirusassociatedwithafulminantpneumoniaoutbreakinanewworldmonkeycolony AT rossptarara crossspeciestransmissionofanoveladenovirusassociatedwithafulminantpneumoniaoutbreakinanewworldmonkeycolony AT donrcanfield crossspeciestransmissionofanoveladenovirusassociatedwithafulminantpneumoniaoutbreakinanewworldmonkeycolony AT nicolemaninger crossspeciestransmissionofanoveladenovirusassociatedwithafulminantpneumoniaoutbreakinanewworldmonkeycolony AT annrosenthal crossspeciestransmissionofanoveladenovirusassociatedwithafulminantpneumoniaoutbreakinanewworldmonkeycolony AT abigailspinner crossspeciestransmissionofanoveladenovirusassociatedwithafulminantpneumoniaoutbreakinanewworldmonkeycolony AT karenlbales crossspeciestransmissionofanoveladenovirusassociatedwithafulminantpneumoniaoutbreakinanewworldmonkeycolony AT davidpschnurr crossspeciestransmissionofanoveladenovirusassociatedwithafulminantpneumoniaoutbreakinanewworldmonkeycolony AT nicholaswlerche crossspeciestransmissionofanoveladenovirusassociatedwithafulminantpneumoniaoutbreakinanewworldmonkeycolony AT charlesychiu crossspeciestransmissionofanoveladenovirusassociatedwithafulminantpneumoniaoutbreakinanewworldmonkeycolony
_version_	1718424694203351040

Cross-species transmission of a novel adenovirus associated with a fulminant pneumonia outbreak in a new world monkey colony.

Ejemplares similares